Brain activation during semantic processing in autism spectrum disorders via functional magnetic resonance imaging
Language and communication deficits are core features of autism spectrum disorders (ASD), even in high-functioning adults with ASD. This study investigated brain activation patterns using functional magnetic resonance imaging in right-handed adult males with ASD and a control group, matched on age,...
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| Veröffentlicht in: | Brain and cognition 2006-06, Vol.61 (1), p.54-68 |
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| creator | Harris, Gordon J. Chabris, Christopher F. Clark, Jill Urban, Trinity Aharon, Itzhak Steele, Shelley McGrath, Lauren Condouris, Karen Tager-Flusberg, Helen |
| description | Language and communication deficits are core features of autism spectrum disorders (ASD), even in high-functioning adults with ASD. This study investigated brain activation patterns using functional magnetic resonance imaging in right-handed adult males with ASD and a control group, matched on age, handedness, and verbal IQ. Semantic processing in the controls produced robust activation in Broca’s area (left inferior frontal gyrus) and in superior medial frontal gyrus and right cerebellum. The ASD group had substantially reduced Broca’s activation, but increased left temporal (Wernicke’s) activation. Furthermore, the ASD group showed diminished activation differences between concrete and abstract words, consistent with behavioral studies. The current study suggests Broca’s area is a region of abnormal neurodevelopment in ASD, which may be linked with semantic and related language deficits frequently observed in ASD. |
| doi_str_mv | 10.1016/j.bandc.2005.12.015 |
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This study investigated brain activation patterns using functional magnetic resonance imaging in right-handed adult males with ASD and a control group, matched on age, handedness, and verbal IQ. Semantic processing in the controls produced robust activation in Broca’s area (left inferior frontal gyrus) and in superior medial frontal gyrus and right cerebellum. The ASD group had substantially reduced Broca’s activation, but increased left temporal (Wernicke’s) activation. Furthermore, the ASD group showed diminished activation differences between concrete and abstract words, consistent with behavioral studies. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Asperger syndrome Autism Autism spectrum disorders Autistic Disorder - physiopathology Brain Brain - physiopathology Communication Disorders - diagnosis Communication Disorders - etiology Control Groups Diagnostic Tests Functional Laterality - physiology Functional magnetic resonance imaging Humans Language Language Disorders - diagnosis Language Disorders - etiology Language Impairments Language Processing Magnetic Resonance Imaging Male Males Reaction Time Semantic processing Semantics Vocabulary |
| title | Brain activation during semantic processing in autism spectrum disorders via functional magnetic resonance imaging |
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