Paternal MHC expression on mouse trophoblast affects uterine vascularization and fetal growth

The mammalian fetus represents a semiallograft within the maternal uterus yet is not rejected. This situation is particularly pronounced in species with a hemochorial type of placentation, such as humans and rodents, where maternal tissues and blood are in direct contact with fetal trophoblast and t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-03, Vol.108 (10), p.4012-4017
Hauptverfasser:	Madeja, Zofia, Yadi, Hakim, Apps, Richard, Boulenouar, Selma, Roper, Stephen J, Gardner, Lucy, Moffett, Ashley, Colucci, Francesco, Hemberger, Myriam
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Biological Sciences Blood vessels Breeding success Cell lines Cell Separation Cell surface Cells decidua Female Fetal Development - genetics Fetus Fetuses Flow Cytometry Genomic Imprinting Giant cells Graft rejection Haplotypes Histocompatibility antigen HLA Immunohistochemistry Major histocompatibility complex Major Histocompatibility Complex - genetics Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Molecules Natural killer cells Placenta Pre-eclampsia Preeclampsia Pregnancy Receptors Reproduction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Rodents Transformation Trophoblasts Trophoblasts - immunology Uterus Uterus - blood supply vascularization
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