Warburg phenotype in renal cell carcinoma: High expression of glucose‐transporter 1 (GLUT‐1) correlates with low CD8+ T‐cell infiltration in the tumor

Many tumor cells are characterized by a dysregulated glucose metabolism associated with increased glycolysis in the presence of oxygen (“Warburg Effect”). Here, we analyzed for the first time a possible link between glucose metabolism and immune cell infiltration in renal cell carcinoma (RCC). RCC s...

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Veröffentlicht in:	International journal of cancer 2011-05, Vol.128 (9), p.2085-2095
Hauptverfasser:	Singer, Katrin, Kastenberger, Michael, Gottfried, Eva, Hammerschmied, Christine G., Büttner, Maike, Aigner, Michael, Seliger, Barbara, Walter, Bernhard, Schlösser, Hans, Hartmann, Arndt, Andreesen, Reinhard, Mackensen, Andreas, Kreutz, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology CD3 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology Clear cells Data processing Effector cells Epithelium Female Foxp3 protein Glucose metabolism Glucose Transporter Type 1 - biosynthesis glucose‐transporter 1 Glycolysis granzyme B Hepatocellular carcinoma Humans immune escape Immunohistochemistry Kidney Kidney Neoplasms - immunology Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kidneys L-Lactate dehydrogenase Lactic acid LDHA Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Male Medical sciences Melanoma Metastases Middle Aged mRNA Neoplasm Staging Nephrology. Urinary tract diseases Oxygen Perforin Phenotype renal cell carcinoma RNA, Messenger - analysis TIL Tissue Array Analysis Tumor cell lines Tumor-infiltrating lymphocytes Tumors Tumors of the urinary system Warburg Young Adult
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