Synthesis of 1H-Pyrazole-1-carboxamide Derivatives and Their Antiproliferative Activity against Melanoma Cell Line

Synthesis of a new series of 1H‐pyrazole‐1‐carboxamide derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the newly synthesized compounds showed moderate activity against A375, compared with sorafenib. Among all of these derivatives, compound IIe which has N‐methylpiperazinyl and phenolic moieties showed the most potent antiproliferative activity against A375 human melanoma cell line. A new series of 3,4‐diaryl‐1H‐pyrazole‐1‐carboxamide derivatives was synthesized. Compound IIe having m‐hydroxyphenyl substituted N‐methylpiperazinyl moieties showed the most potent antiproliferative activity against A375 human melanoma cell line.