Factors associated with plasma ghrelin level in Japanese general population
Objective Ghrelin is a novel gastric peptide identified in 1999 as a ‘hunger hormone’. Plasma ghrelin level is decreased in human obesity. Factors associated with ghrelin have been mainly investigated in western countries where the prevalence of obesity is high. The aim of this study is to examine...
Gespeichert in:
| Veröffentlicht in: | Clinical endocrinology (Oxford) 2011-04, Vol.74 (4), p.453-458 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 458 |
|---|---|
| container_issue | 4 |
| container_start_page | 453 |
| container_title | Clinical endocrinology (Oxford) |
| container_volume | 74 |
| creator | Nanjo, Yasuki Adachi, Hisashi Hirai, Yuji Enomoto, Mika Fukami, Ako Otsuka, Maki Yoshikawa, Kuniko Yokoi, Kanako Ogata, Kinuka Tsukagawa, Eri Kasahara, Akiko Murayama, Kyoko Yasukawa, Hideo Kojima, Masayasu Imaizumi, Tsutomu |
| description | Objective Ghrelin is a novel gastric peptide identified in 1999 as a ‘hunger hormone’. Plasma ghrelin level is decreased in human obesity. Factors associated with ghrelin have been mainly investigated in western countries where the prevalence of obesity is high. The aim of this study is to examine factors associated with plasma ghrelin in a Japanese general population where obesity is not so common.
Methods Fasting ghrelin levels were measured by ELISA in 638 subjects in 2005–2007. We measured body mass index (BMI), waist circumference and blood pressure. Blood was drawn in the morning after a 12‐h fast for determinations of ghrelin, lipid, glucose (FPG), insulin, estimated glomerular filtration rate (eGFR) and uric acid levels. Univariate and multiple stepwise regression analyses were performed to find out factors associated with ghrelin.
Results In our population, the mean BMI was 23·8 kg/m2, indicating a nonobese population. Results of univariate analysis showed that age (P |
| doi_str_mv | 10.1111/j.1365-2265.2010.03938.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_855910966</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3317525131</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4158-3b17c38a524682397569785dd33a6b9db49cb9321db82195d26418badf0ebc273</originalsourceid><addsrcrecordid>eNpdkV1v0zAUhi0EYmXwF5AlhLhK8Ufs2BdcoGod-9B2MzSJG-vEcTcXN8nshHX_Hod2RZpvfOTzvNaxH4QwJXOa19f1nHIpCsakmDOSTwnXXM23r9Ds0HiNZoQTUhApyyP0LqU1IUQoUr1FR4wSzYigM3SxBDt0MWFIqbMeBtfgRz_c4z5A2gC-u48u-BYH98cFnItz6KF1yeE717oIAfddPwYYfNe-R29WEJL7sN-P0c_lyc3iR3F5fXq2-H5Z2JIKVfCaVpYrEKyUinFdCakrJZqGc5C1bupS21pzRptaMapFw2RJVQ3Nirjasoofoy-7e_vYPYwuDWbjk3Uh5MG6MRklhM4PlDKTn16Q626MbR7OUMG0kKUodaY-7qmx3rjG9NFvID6Z51_KwOc9AMlCWEVorU__Oa6ZIrrM3Lcd9-iDezr0KTGTNbM2kxwzyTGTNfPPmtmaxcnVVOV8scv7NLjtIQ_xt5EVr4S5vTo1ein1ze1SmF_8LwbBl4M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1529564549</pqid></control><display><type>article</type><title>Factors associated with plasma ghrelin level in Japanese general population</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Nanjo, Yasuki ; Adachi, Hisashi ; Hirai, Yuji ; Enomoto, Mika ; Fukami, Ako ; Otsuka, Maki ; Yoshikawa, Kuniko ; Yokoi, Kanako ; Ogata, Kinuka ; Tsukagawa, Eri ; Kasahara, Akiko ; Murayama, Kyoko ; Yasukawa, Hideo ; Kojima, Masayasu ; Imaizumi, Tsutomu</creator><creatorcontrib>Nanjo, Yasuki ; Adachi, Hisashi ; Hirai, Yuji ; Enomoto, Mika ; Fukami, Ako ; Otsuka, Maki ; Yoshikawa, Kuniko ; Yokoi, Kanako ; Ogata, Kinuka ; Tsukagawa, Eri ; Kasahara, Akiko ; Murayama, Kyoko ; Yasukawa, Hideo ; Kojima, Masayasu ; Imaizumi, Tsutomu</creatorcontrib><description><![CDATA[Objective Ghrelin is a novel gastric peptide identified in 1999 as a ‘hunger hormone’. Plasma ghrelin level is decreased in human obesity. Factors associated with ghrelin have been mainly investigated in western countries where the prevalence of obesity is high. The aim of this study is to examine factors associated with plasma ghrelin in a Japanese general population where obesity is not so common.
Methods Fasting ghrelin levels were measured by ELISA in 638 subjects in 2005–2007. We measured body mass index (BMI), waist circumference and blood pressure. Blood was drawn in the morning after a 12‐h fast for determinations of ghrelin, lipid, glucose (FPG), insulin, estimated glomerular filtration rate (eGFR) and uric acid levels. Univariate and multiple stepwise regression analyses were performed to find out factors associated with ghrelin.
Results In our population, the mean BMI was 23·8 kg/m2, indicating a nonobese population. Results of univariate analysis showed that age (P < 0·001), BMI (P < 0·001), waist (P < 0·001), triglycerides (P < 0·01), FPG (P < 0·01), insulin (P < 0·001) and uric acid (P < 0·05) were inversely associated with ghrelin. High‐density lipoprotein (HDL) cholesterol (P < 0·001) and eGFR (P < 0·05) were positively associated with ghrelin. Men had lower ghrelin levels than women (P < 0·001). Results of the multiple stepwise regression analysis revealed that age (P < 0·001; inversely), female gender (P < 0·001), insulin (P < 0·001; inversely), HDL cholesterol (P = 0·005), BMI (P = 0·01; inversely) and uric acid (P = 0·045; inversely) were significantly and independently associated with ghrelin.
Conclusions The present study demonstrated that age and gender affected plasma ghrelin levels more than BMI. This may well be because of the low prevalence of overweight in our population.]]></description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2010.03938.x</identifier><identifier>PMID: 21092051</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Asian Continental Ancestry Group ; Biological and medical sciences ; Blood Glucose - metabolism ; Blood Pressure - physiology ; Body Mass Index ; Endocrinopathies ; Enzyme-Linked Immunosorbent Assay ; Fasting - blood ; Female ; Fundamental and applied biological sciences. Psychology ; Ghrelin - blood ; Humans ; Insulin - blood ; Male ; Medical sciences ; Middle Aged ; Vertebrates: endocrinology ; Waist Circumference - physiology</subject><ispartof>Clinical endocrinology (Oxford), 2011-04, Vol.74 (4), p.453-458</ispartof><rights>2011 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2011 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4158-3b17c38a524682397569785dd33a6b9db49cb9321db82195d26418badf0ebc273</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2010.03938.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2010.03938.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23928094$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21092051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nanjo, Yasuki</creatorcontrib><creatorcontrib>Adachi, Hisashi</creatorcontrib><creatorcontrib>Hirai, Yuji</creatorcontrib><creatorcontrib>Enomoto, Mika</creatorcontrib><creatorcontrib>Fukami, Ako</creatorcontrib><creatorcontrib>Otsuka, Maki</creatorcontrib><creatorcontrib>Yoshikawa, Kuniko</creatorcontrib><creatorcontrib>Yokoi, Kanako</creatorcontrib><creatorcontrib>Ogata, Kinuka</creatorcontrib><creatorcontrib>Tsukagawa, Eri</creatorcontrib><creatorcontrib>Kasahara, Akiko</creatorcontrib><creatorcontrib>Murayama, Kyoko</creatorcontrib><creatorcontrib>Yasukawa, Hideo</creatorcontrib><creatorcontrib>Kojima, Masayasu</creatorcontrib><creatorcontrib>Imaizumi, Tsutomu</creatorcontrib><title>Factors associated with plasma ghrelin level in Japanese general population</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description><![CDATA[Objective Ghrelin is a novel gastric peptide identified in 1999 as a ‘hunger hormone’. Plasma ghrelin level is decreased in human obesity. Factors associated with ghrelin have been mainly investigated in western countries where the prevalence of obesity is high. The aim of this study is to examine factors associated with plasma ghrelin in a Japanese general population where obesity is not so common.
Methods Fasting ghrelin levels were measured by ELISA in 638 subjects in 2005–2007. We measured body mass index (BMI), waist circumference and blood pressure. Blood was drawn in the morning after a 12‐h fast for determinations of ghrelin, lipid, glucose (FPG), insulin, estimated glomerular filtration rate (eGFR) and uric acid levels. Univariate and multiple stepwise regression analyses were performed to find out factors associated with ghrelin.
Results In our population, the mean BMI was 23·8 kg/m2, indicating a nonobese population. Results of univariate analysis showed that age (P < 0·001), BMI (P < 0·001), waist (P < 0·001), triglycerides (P < 0·01), FPG (P < 0·01), insulin (P < 0·001) and uric acid (P < 0·05) were inversely associated with ghrelin. High‐density lipoprotein (HDL) cholesterol (P < 0·001) and eGFR (P < 0·05) were positively associated with ghrelin. Men had lower ghrelin levels than women (P < 0·001). Results of the multiple stepwise regression analysis revealed that age (P < 0·001; inversely), female gender (P < 0·001), insulin (P < 0·001; inversely), HDL cholesterol (P = 0·005), BMI (P = 0·01; inversely) and uric acid (P = 0·045; inversely) were significantly and independently associated with ghrelin.
Conclusions The present study demonstrated that age and gender affected plasma ghrelin levels more than BMI. This may well be because of the low prevalence of overweight in our population.]]></description><subject>Aged</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure - physiology</subject><subject>Body Mass Index</subject><subject>Endocrinopathies</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ghrelin - blood</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Vertebrates: endocrinology</subject><subject>Waist Circumference - physiology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1v0zAUhi0EYmXwF5AlhLhK8Ufs2BdcoGod-9B2MzSJG-vEcTcXN8nshHX_Hod2RZpvfOTzvNaxH4QwJXOa19f1nHIpCsakmDOSTwnXXM23r9Ds0HiNZoQTUhApyyP0LqU1IUQoUr1FR4wSzYigM3SxBDt0MWFIqbMeBtfgRz_c4z5A2gC-u48u-BYH98cFnItz6KF1yeE717oIAfddPwYYfNe-R29WEJL7sN-P0c_lyc3iR3F5fXq2-H5Z2JIKVfCaVpYrEKyUinFdCakrJZqGc5C1bupS21pzRptaMapFw2RJVQ3Nirjasoofoy-7e_vYPYwuDWbjk3Uh5MG6MRklhM4PlDKTn16Q626MbR7OUMG0kKUodaY-7qmx3rjG9NFvID6Z51_KwOc9AMlCWEVorU__Oa6ZIrrM3Lcd9-iDezr0KTGTNbM2kxwzyTGTNfPPmtmaxcnVVOV8scv7NLjtIQ_xt5EVr4S5vTo1ein1ze1SmF_8LwbBl4M</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Nanjo, Yasuki</creator><creator>Adachi, Hisashi</creator><creator>Hirai, Yuji</creator><creator>Enomoto, Mika</creator><creator>Fukami, Ako</creator><creator>Otsuka, Maki</creator><creator>Yoshikawa, Kuniko</creator><creator>Yokoi, Kanako</creator><creator>Ogata, Kinuka</creator><creator>Tsukagawa, Eri</creator><creator>Kasahara, Akiko</creator><creator>Murayama, Kyoko</creator><creator>Yasukawa, Hideo</creator><creator>Kojima, Masayasu</creator><creator>Imaizumi, Tsutomu</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Factors associated with plasma ghrelin level in Japanese general population</title><author>Nanjo, Yasuki ; Adachi, Hisashi ; Hirai, Yuji ; Enomoto, Mika ; Fukami, Ako ; Otsuka, Maki ; Yoshikawa, Kuniko ; Yokoi, Kanako ; Ogata, Kinuka ; Tsukagawa, Eri ; Kasahara, Akiko ; Murayama, Kyoko ; Yasukawa, Hideo ; Kojima, Masayasu ; Imaizumi, Tsutomu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4158-3b17c38a524682397569785dd33a6b9db49cb9321db82195d26418badf0ebc273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure - physiology</topic><topic>Body Mass Index</topic><topic>Endocrinopathies</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Fasting - blood</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ghrelin - blood</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Vertebrates: endocrinology</topic><topic>Waist Circumference - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nanjo, Yasuki</creatorcontrib><creatorcontrib>Adachi, Hisashi</creatorcontrib><creatorcontrib>Hirai, Yuji</creatorcontrib><creatorcontrib>Enomoto, Mika</creatorcontrib><creatorcontrib>Fukami, Ako</creatorcontrib><creatorcontrib>Otsuka, Maki</creatorcontrib><creatorcontrib>Yoshikawa, Kuniko</creatorcontrib><creatorcontrib>Yokoi, Kanako</creatorcontrib><creatorcontrib>Ogata, Kinuka</creatorcontrib><creatorcontrib>Tsukagawa, Eri</creatorcontrib><creatorcontrib>Kasahara, Akiko</creatorcontrib><creatorcontrib>Murayama, Kyoko</creatorcontrib><creatorcontrib>Yasukawa, Hideo</creatorcontrib><creatorcontrib>Kojima, Masayasu</creatorcontrib><creatorcontrib>Imaizumi, Tsutomu</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nanjo, Yasuki</au><au>Adachi, Hisashi</au><au>Hirai, Yuji</au><au>Enomoto, Mika</au><au>Fukami, Ako</au><au>Otsuka, Maki</au><au>Yoshikawa, Kuniko</au><au>Yokoi, Kanako</au><au>Ogata, Kinuka</au><au>Tsukagawa, Eri</au><au>Kasahara, Akiko</au><au>Murayama, Kyoko</au><au>Yasukawa, Hideo</au><au>Kojima, Masayasu</au><au>Imaizumi, Tsutomu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with plasma ghrelin level in Japanese general population</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2011-04</date><risdate>2011</risdate><volume>74</volume><issue>4</issue><spage>453</spage><epage>458</epage><pages>453-458</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract><![CDATA[Objective Ghrelin is a novel gastric peptide identified in 1999 as a ‘hunger hormone’. Plasma ghrelin level is decreased in human obesity. Factors associated with ghrelin have been mainly investigated in western countries where the prevalence of obesity is high. The aim of this study is to examine factors associated with plasma ghrelin in a Japanese general population where obesity is not so common.
Methods Fasting ghrelin levels were measured by ELISA in 638 subjects in 2005–2007. We measured body mass index (BMI), waist circumference and blood pressure. Blood was drawn in the morning after a 12‐h fast for determinations of ghrelin, lipid, glucose (FPG), insulin, estimated glomerular filtration rate (eGFR) and uric acid levels. Univariate and multiple stepwise regression analyses were performed to find out factors associated with ghrelin.
Results In our population, the mean BMI was 23·8 kg/m2, indicating a nonobese population. Results of univariate analysis showed that age (P < 0·001), BMI (P < 0·001), waist (P < 0·001), triglycerides (P < 0·01), FPG (P < 0·01), insulin (P < 0·001) and uric acid (P < 0·05) were inversely associated with ghrelin. High‐density lipoprotein (HDL) cholesterol (P < 0·001) and eGFR (P < 0·05) were positively associated with ghrelin. Men had lower ghrelin levels than women (P < 0·001). Results of the multiple stepwise regression analysis revealed that age (P < 0·001; inversely), female gender (P < 0·001), insulin (P < 0·001; inversely), HDL cholesterol (P = 0·005), BMI (P = 0·01; inversely) and uric acid (P = 0·045; inversely) were significantly and independently associated with ghrelin.
Conclusions The present study demonstrated that age and gender affected plasma ghrelin levels more than BMI. This may well be because of the low prevalence of overweight in our population.]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21092051</pmid><doi>10.1111/j.1365-2265.2010.03938.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-0664 |
| ispartof | Clinical endocrinology (Oxford), 2011-04, Vol.74 (4), p.453-458 |
| issn | 0300-0664 1365-2265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_855910966 |
| source | MEDLINE; Wiley Journals |
| subjects | Aged Asian Continental Ancestry Group Biological and medical sciences Blood Glucose - metabolism Blood Pressure - physiology Body Mass Index Endocrinopathies Enzyme-Linked Immunosorbent Assay Fasting - blood Female Fundamental and applied biological sciences. Psychology Ghrelin - blood Humans Insulin - blood Male Medical sciences Middle Aged Vertebrates: endocrinology Waist Circumference - physiology |
| title | Factors associated with plasma ghrelin level in Japanese general population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T03%3A06%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Factors%20associated%20with%20plasma%20ghrelin%20level%20in%20Japanese%20general%20population&rft.jtitle=Clinical%20endocrinology%20(Oxford)&rft.au=Nanjo,%20Yasuki&rft.date=2011-04&rft.volume=74&rft.issue=4&rft.spage=453&rft.epage=458&rft.pages=453-458&rft.issn=0300-0664&rft.eissn=1365-2265&rft.coden=CLECAP&rft_id=info:doi/10.1111/j.1365-2265.2010.03938.x&rft_dat=%3Cproquest_pubme%3E3317525131%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1529564549&rft_id=info:pmid/21092051&rfr_iscdi=true |