Comparative study of human eutopic and ectopic endometrial mesenchymal stem cells and the development of an in vivo endometriotic invasion model
Objective To elucidate the role of endometrial stem-progenitor cells in the etiology of endometriosis and to develop an animal model to study the invasion ability of endometrial cells. Design Gene expression and cell function studies were designed. Setting Kaohsiung Medical University Hospital, Kaoh...
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| Veröffentlicht in: | Fertility and sterility 2011-03, Vol.95 (4), p.1308-1315.e1 |
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| creator | Kao, An-Pei, M.S Wang, Kai-Hung, M.S Chang, Chia-Cheng, Ph.D Lee, Jau-Nan, M.D., Ph.D Long, Cheng-Yu, M.D., Ph.D Chen, Hung-Sheng, M.D Tsai, Cheng-Fang, B.S Hsieh, Tsung-Hua, M.S Tsai, Eing-Mei, M.D., Ph.D |
| description | Objective To elucidate the role of endometrial stem-progenitor cells in the etiology of endometriosis and to develop an animal model to study the invasion ability of endometrial cells. Design Gene expression and cell function studies were designed. Setting Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Patient(s) Human endometrial mesenchymal stem cells (MSCs) were isolated from 22 different endometrium biopsies after surgery for treatment of endometriosis. Intervention(s) Endometrial MSCs developed from eutopic and ectopic endometrial tissues. Main Outcome Measure(s) Characterization of MSC phenotypes (i.e., differentiation induction and gene expression by flow cytometric analysis); comparative study of cell functions (i.e., cell growth, migration, and invasion assays). The invasion of implants in an animal model was examined by histologic staining. Result(s) We compared the characteristics of eutopic and ectopic endometrial MSCs from the same endometrial donor. Although both showed similar mesenchymal cell phenotypes, ectopic endometrial MSCs showed distinctly greater ability of cell migration and invasion. Furthermore, in an in vivo cell invasion model using cells grown in scaffold and transplantation in immune-deficient mice, the ectopic endometrial MSCs were found to form many new blood vessels and to invade surrounding tissue. Conclusion(s) These results indicate unique invasion and angiogenesis characteristics of ectopic endometrial MSCs that may underlie the pathogenesis of ectopic endometriosis. The animal invasion model will be useful for future characterization of endometrial MSCs. |
| doi_str_mv | 10.1016/j.fertnstert.2010.09.064 |
| format | Article |
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Design Gene expression and cell function studies were designed. Setting Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Patient(s) Human endometrial mesenchymal stem cells (MSCs) were isolated from 22 different endometrium biopsies after surgery for treatment of endometriosis. Intervention(s) Endometrial MSCs developed from eutopic and ectopic endometrial tissues. Main Outcome Measure(s) Characterization of MSC phenotypes (i.e., differentiation induction and gene expression by flow cytometric analysis); comparative study of cell functions (i.e., cell growth, migration, and invasion assays). The invasion of implants in an animal model was examined by histologic staining. Result(s) We compared the characteristics of eutopic and ectopic endometrial MSCs from the same endometrial donor. Although both showed similar mesenchymal cell phenotypes, ectopic endometrial MSCs showed distinctly greater ability of cell migration and invasion. Furthermore, in an in vivo cell invasion model using cells grown in scaffold and transplantation in immune-deficient mice, the ectopic endometrial MSCs were found to form many new blood vessels and to invade surrounding tissue. Conclusion(s) These results indicate unique invasion and angiogenesis characteristics of ectopic endometrial MSCs that may underlie the pathogenesis of ectopic endometriosis. The animal invasion model will be useful for future characterization of endometrial MSCs.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2010.09.064</identifier><identifier>PMID: 21047634</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>angiogenesis ; animal model ; animal models ; Animals ; Biological and medical sciences ; blood vessels ; cell growth ; cell invasion ; cell movement ; Cell Movement - physiology ; Cell Proliferation ; Cells, Cultured ; Choristoma ; Disease Models, Animal ; Endometriosis ; Endometriosis - etiology ; Endometriosis - pathology ; Endometrium ; etiology ; Female ; Female genital diseases ; flow cytometry ; gene expression ; gene induction ; Gynecology. Andrology. Obstetrics ; Humans ; Internal Medicine ; invasion ; Medical sciences ; Mesenchymal Stem Cell Transplantation - methods ; mesenchymal stem cells ; Mesenchymal Stromal Cells - pathology ; Mice ; Mice, Inbred BALB C ; Mice, SCID ; Non tumoral diseases ; Obstetrics and Gynecology ; pathogenesis ; patients ; phenotype ; stem cells ; surgery</subject><ispartof>Fertility and sterility, 2011-03, Vol.95 (4), p.1308-1315.e1</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2011 American Society for Reproductive Medicine</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-3dc2a62843a14280efb2264b9cc79beee9495affc7a2119c63dfefa1eb700f213</citedby><cites>FETCH-LOGICAL-c532t-3dc2a62843a14280efb2264b9cc79beee9495affc7a2119c63dfefa1eb700f213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fertnstert.2010.09.064$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23960707$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21047634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kao, An-Pei, M.S</creatorcontrib><creatorcontrib>Wang, Kai-Hung, M.S</creatorcontrib><creatorcontrib>Chang, Chia-Cheng, Ph.D</creatorcontrib><creatorcontrib>Lee, Jau-Nan, M.D., Ph.D</creatorcontrib><creatorcontrib>Long, Cheng-Yu, M.D., Ph.D</creatorcontrib><creatorcontrib>Chen, Hung-Sheng, M.D</creatorcontrib><creatorcontrib>Tsai, Cheng-Fang, B.S</creatorcontrib><creatorcontrib>Hsieh, Tsung-Hua, M.S</creatorcontrib><creatorcontrib>Tsai, Eing-Mei, M.D., Ph.D</creatorcontrib><title>Comparative study of human eutopic and ectopic endometrial mesenchymal stem cells and the development of an in vivo endometriotic invasion model</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To elucidate the role of endometrial stem-progenitor cells in the etiology of endometriosis and to develop an animal model to study the invasion ability of endometrial cells. Design Gene expression and cell function studies were designed. Setting Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Patient(s) Human endometrial mesenchymal stem cells (MSCs) were isolated from 22 different endometrium biopsies after surgery for treatment of endometriosis. Intervention(s) Endometrial MSCs developed from eutopic and ectopic endometrial tissues. Main Outcome Measure(s) Characterization of MSC phenotypes (i.e., differentiation induction and gene expression by flow cytometric analysis); comparative study of cell functions (i.e., cell growth, migration, and invasion assays). The invasion of implants in an animal model was examined by histologic staining. Result(s) We compared the characteristics of eutopic and ectopic endometrial MSCs from the same endometrial donor. Although both showed similar mesenchymal cell phenotypes, ectopic endometrial MSCs showed distinctly greater ability of cell migration and invasion. Furthermore, in an in vivo cell invasion model using cells grown in scaffold and transplantation in immune-deficient mice, the ectopic endometrial MSCs were found to form many new blood vessels and to invade surrounding tissue. Conclusion(s) These results indicate unique invasion and angiogenesis characteristics of ectopic endometrial MSCs that may underlie the pathogenesis of ectopic endometriosis. The animal invasion model will be useful for future characterization of endometrial MSCs.</description><subject>angiogenesis</subject><subject>animal model</subject><subject>animal models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>blood vessels</subject><subject>cell growth</subject><subject>cell invasion</subject><subject>cell movement</subject><subject>Cell Movement - physiology</subject><subject>Cell Proliferation</subject><subject>Cells, Cultured</subject><subject>Choristoma</subject><subject>Disease Models, Animal</subject><subject>Endometriosis</subject><subject>Endometriosis - etiology</subject><subject>Endometriosis - pathology</subject><subject>Endometrium</subject><subject>etiology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>flow cytometry</subject><subject>gene expression</subject><subject>gene induction</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>invasion</subject><subject>Medical sciences</subject><subject>Mesenchymal Stem Cell Transplantation - methods</subject><subject>mesenchymal stem cells</subject><subject>Mesenchymal Stromal Cells - pathology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, SCID</subject><subject>Non tumoral diseases</subject><subject>Obstetrics and Gynecology</subject><subject>pathogenesis</subject><subject>patients</subject><subject>phenotype</subject><subject>stem cells</subject><subject>surgery</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks-O0zAQxiMEYpeFVwBfEKeWsRM7yQUJKv5JK3FY9my5zpi6xHaxnUh9Cx4ZhxYqceJij6zffDOeb6qKUFhToOL1fm0wZp9yOdcMyjP0axDNg-qaci5WXPD6YXUNQPkKWMeuqicp7QFA0JY9rq4YhaYVdXNd_dwEd1BRZTsjSXkajiQYspuc8gSnHA5WE-UHgvoUox-CwxytGonDhF7vjq7EpRVHNI5j-o3nHZIBZxzDwaHPi2YRtJ7Mdg4XkZCLpPWzSjZ44sKA49PqkVFjwmfn-6a6__D-6-bT6vbLx8-bt7crzWuWV_WgmRKsa2pFG9YBmi1jotn2Wrf9FhH7pufKGN0qRmmvRT0YNIritgUwjNY31auT7iGGHxOmLJ1NyweUxzAl2XHeU-g6VsjuROoYUopo5CFap-JRUpCLHXIvL3bIxQ4JvSx2lNTn5yLT1uHwN_HP_Avw8gyopNVoovLapgtX9wJaaAv34sQZFaT6Fgtzf1cq8WIxazkVhXh3IrAMbbYYZdK22IODjcU8OQT7P_2--UdEj9bb0tl3PGLahyn6YoqkMjEJ8m5ZsGW_KAATbdvUvwDwVdA7</recordid><startdate>20110315</startdate><enddate>20110315</enddate><creator>Kao, An-Pei, M.S</creator><creator>Wang, Kai-Hung, M.S</creator><creator>Chang, Chia-Cheng, Ph.D</creator><creator>Lee, Jau-Nan, M.D., Ph.D</creator><creator>Long, Cheng-Yu, M.D., Ph.D</creator><creator>Chen, Hung-Sheng, M.D</creator><creator>Tsai, Cheng-Fang, B.S</creator><creator>Hsieh, Tsung-Hua, M.S</creator><creator>Tsai, Eing-Mei, M.D., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110315</creationdate><title>Comparative study of human eutopic and ectopic endometrial mesenchymal stem cells and the development of an in vivo endometriotic invasion model</title><author>Kao, An-Pei, M.S ; Wang, Kai-Hung, M.S ; Chang, Chia-Cheng, Ph.D ; Lee, Jau-Nan, M.D., Ph.D ; Long, Cheng-Yu, M.D., Ph.D ; Chen, Hung-Sheng, M.D ; Tsai, Cheng-Fang, B.S ; Hsieh, Tsung-Hua, M.S ; Tsai, Eing-Mei, M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-3dc2a62843a14280efb2264b9cc79beee9495affc7a2119c63dfefa1eb700f213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>angiogenesis</topic><topic>animal model</topic><topic>animal models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>blood vessels</topic><topic>cell growth</topic><topic>cell invasion</topic><topic>cell movement</topic><topic>Cell Movement - physiology</topic><topic>Cell Proliferation</topic><topic>Cells, Cultured</topic><topic>Choristoma</topic><topic>Disease Models, Animal</topic><topic>Endometriosis</topic><topic>Endometriosis - etiology</topic><topic>Endometriosis - pathology</topic><topic>Endometrium</topic><topic>etiology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>flow cytometry</topic><topic>gene expression</topic><topic>gene induction</topic><topic>Gynecology. 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Obstetrics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>invasion</topic><topic>Medical sciences</topic><topic>Mesenchymal Stem Cell Transplantation - methods</topic><topic>mesenchymal stem cells</topic><topic>Mesenchymal Stromal Cells - pathology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, SCID</topic><topic>Non tumoral diseases</topic><topic>Obstetrics and Gynecology</topic><topic>pathogenesis</topic><topic>patients</topic><topic>phenotype</topic><topic>stem cells</topic><topic>surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kao, An-Pei, M.S</creatorcontrib><creatorcontrib>Wang, Kai-Hung, M.S</creatorcontrib><creatorcontrib>Chang, Chia-Cheng, Ph.D</creatorcontrib><creatorcontrib>Lee, Jau-Nan, M.D., Ph.D</creatorcontrib><creatorcontrib>Long, Cheng-Yu, M.D., Ph.D</creatorcontrib><creatorcontrib>Chen, Hung-Sheng, M.D</creatorcontrib><creatorcontrib>Tsai, Cheng-Fang, B.S</creatorcontrib><creatorcontrib>Hsieh, Tsung-Hua, M.S</creatorcontrib><creatorcontrib>Tsai, Eing-Mei, M.D., Ph.D</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kao, An-Pei, M.S</au><au>Wang, Kai-Hung, M.S</au><au>Chang, Chia-Cheng, Ph.D</au><au>Lee, Jau-Nan, M.D., Ph.D</au><au>Long, Cheng-Yu, M.D., Ph.D</au><au>Chen, Hung-Sheng, M.D</au><au>Tsai, Cheng-Fang, B.S</au><au>Hsieh, Tsung-Hua, M.S</au><au>Tsai, Eing-Mei, M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative study of human eutopic and ectopic endometrial mesenchymal stem cells and the development of an in vivo endometriotic invasion model</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2011-03-15</date><risdate>2011</risdate><volume>95</volume><issue>4</issue><spage>1308</spage><epage>1315.e1</epage><pages>1308-1315.e1</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective To elucidate the role of endometrial stem-progenitor cells in the etiology of endometriosis and to develop an animal model to study the invasion ability of endometrial cells. Design Gene expression and cell function studies were designed. Setting Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Patient(s) Human endometrial mesenchymal stem cells (MSCs) were isolated from 22 different endometrium biopsies after surgery for treatment of endometriosis. Intervention(s) Endometrial MSCs developed from eutopic and ectopic endometrial tissues. Main Outcome Measure(s) Characterization of MSC phenotypes (i.e., differentiation induction and gene expression by flow cytometric analysis); comparative study of cell functions (i.e., cell growth, migration, and invasion assays). The invasion of implants in an animal model was examined by histologic staining. Result(s) We compared the characteristics of eutopic and ectopic endometrial MSCs from the same endometrial donor. Although both showed similar mesenchymal cell phenotypes, ectopic endometrial MSCs showed distinctly greater ability of cell migration and invasion. Furthermore, in an in vivo cell invasion model using cells grown in scaffold and transplantation in immune-deficient mice, the ectopic endometrial MSCs were found to form many new blood vessels and to invade surrounding tissue. Conclusion(s) These results indicate unique invasion and angiogenesis characteristics of ectopic endometrial MSCs that may underlie the pathogenesis of ectopic endometriosis. The animal invasion model will be useful for future characterization of endometrial MSCs.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21047634</pmid><doi>10.1016/j.fertnstert.2010.09.064</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | angiogenesis animal model animal models Animals Biological and medical sciences blood vessels cell growth cell invasion cell movement Cell Movement - physiology Cell Proliferation Cells, Cultured Choristoma Disease Models, Animal Endometriosis Endometriosis - etiology Endometriosis - pathology Endometrium etiology Female Female genital diseases flow cytometry gene expression gene induction Gynecology. Andrology. Obstetrics Humans Internal Medicine invasion Medical sciences Mesenchymal Stem Cell Transplantation - methods mesenchymal stem cells Mesenchymal Stromal Cells - pathology Mice Mice, Inbred BALB C Mice, SCID Non tumoral diseases Obstetrics and Gynecology pathogenesis patients phenotype stem cells surgery |
| title | Comparative study of human eutopic and ectopic endometrial mesenchymal stem cells and the development of an in vivo endometriotic invasion model |
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