Does recovery of adrenal function occur in patients with autoimmune Addison's disease?
Summary Objective We earlier discovered partial recovery in a patient with autoimmune Addison’s disease. The aim of this study was to assess the occurrence of adrenocortical recovery in patients with autoimmune adrenalitis. Design Cross‐sectional study. Patients Twenty‐seven adult patients with a...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2011-04, Vol.74 (4), p.434-437 |
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| creator | Smans, Lisanne C. C. J. Zelissen, Pierre M. J. |
| description | Summary
Objective We earlier discovered partial recovery in a patient with autoimmune Addison’s disease. The aim of this study was to assess the occurrence of adrenocortical recovery in patients with autoimmune adrenalitis.
Design Cross‐sectional study.
Patients Twenty‐seven adult patients with autoimmune Addison’s disease on stable glucocorticoid and mineralocorticoid replacement therapy (RT) attending the Department of Endocrinology of a university teaching hospital were included in this study.
Methods Adrenocortical function was assessed by performing an adrenocorticotrophic hormone (ACTH) (250 μg Synacthen) stimulation test (SST) after interruption of current glucocorticoid and mineralocorticoid RT. A normal adrenal response was defined as a serum cortisol concentration ≥500 nm 30 or 60 min after stimulation. Partial recovery was defined as a cortisol concentration ≥100 and ≤500 nm after stimulation.
Results In 17 patients (63%), serum cortisol concentrations remained undetectable 30 and 60 min after the administration of ACTH. None of the remaining 10 participants had a normal response. Only one patient reached a cortisol concentration of 100 nm after 60 min, but this could not be confirmed during a second SST.
Conclusions In this cross‐sectional study among 27 patients with autoimmune adrenalitis, no new cases of adrenocortical recovery were found. |
| doi_str_mv | 10.1111/j.1365-2265.2010.03944.x |
| format | Article |
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Objective We earlier discovered partial recovery in a patient with autoimmune Addison’s disease. The aim of this study was to assess the occurrence of adrenocortical recovery in patients with autoimmune adrenalitis.
Design Cross‐sectional study.
Patients Twenty‐seven adult patients with autoimmune Addison’s disease on stable glucocorticoid and mineralocorticoid replacement therapy (RT) attending the Department of Endocrinology of a university teaching hospital were included in this study.
Methods Adrenocortical function was assessed by performing an adrenocorticotrophic hormone (ACTH) (250 μg Synacthen) stimulation test (SST) after interruption of current glucocorticoid and mineralocorticoid RT. A normal adrenal response was defined as a serum cortisol concentration ≥500 nm 30 or 60 min after stimulation. Partial recovery was defined as a cortisol concentration ≥100 and ≤500 nm after stimulation.
Results In 17 patients (63%), serum cortisol concentrations remained undetectable 30 and 60 min after the administration of ACTH. None of the remaining 10 participants had a normal response. Only one patient reached a cortisol concentration of 100 nm after 60 min, but this could not be confirmed during a second SST.
Conclusions In this cross‐sectional study among 27 patients with autoimmune adrenalitis, no new cases of adrenocortical recovery were found.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2010.03944.x</identifier><identifier>PMID: 21114513</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Addison Disease - blood ; Addison Disease - drug therapy ; Addison Disease - physiopathology ; Adrenal glands ; Adrenal Glands - drug effects ; Adrenal Glands - metabolism ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Adrenocorticotropic Hormone - pharmacology ; Adult ; Aged ; Biological and medical sciences ; Cross-Sectional Studies ; Drug therapy ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Glucocorticoids - therapeutic use ; Humans ; Hydrocortisone - blood ; Male ; Medical research ; Medical sciences ; Middle Aged ; Mineralocorticoids - therapeutic use ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Vertebrates: endocrinology ; Young Adult</subject><ispartof>Clinical endocrinology (Oxford), 2011-04, Vol.74 (4), p.434-437</ispartof><rights>2011 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2011 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4484-8ded420c7664dfe0effe71d4a924fe4597a75ec0c39b310cfa764bb1f6053e263</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2010.03944.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2010.03944.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23928091$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21114513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smans, Lisanne C. C. J.</creatorcontrib><creatorcontrib>Zelissen, Pierre M. J.</creatorcontrib><title>Does recovery of adrenal function occur in patients with autoimmune Addison's disease?</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Objective We earlier discovered partial recovery in a patient with autoimmune Addison’s disease. The aim of this study was to assess the occurrence of adrenocortical recovery in patients with autoimmune adrenalitis.
Design Cross‐sectional study.
Patients Twenty‐seven adult patients with autoimmune Addison’s disease on stable glucocorticoid and mineralocorticoid replacement therapy (RT) attending the Department of Endocrinology of a university teaching hospital were included in this study.
Methods Adrenocortical function was assessed by performing an adrenocorticotrophic hormone (ACTH) (250 μg Synacthen) stimulation test (SST) after interruption of current glucocorticoid and mineralocorticoid RT. A normal adrenal response was defined as a serum cortisol concentration ≥500 nm 30 or 60 min after stimulation. Partial recovery was defined as a cortisol concentration ≥100 and ≤500 nm after stimulation.
Results In 17 patients (63%), serum cortisol concentrations remained undetectable 30 and 60 min after the administration of ACTH. None of the remaining 10 participants had a normal response. Only one patient reached a cortisol concentration of 100 nm after 60 min, but this could not be confirmed during a second SST.
Conclusions In this cross‐sectional study among 27 patients with autoimmune adrenalitis, no new cases of adrenocortical recovery were found.</description><subject>Addison Disease - blood</subject><subject>Addison Disease - drug therapy</subject><subject>Addison Disease - physiopathology</subject><subject>Adrenal glands</subject><subject>Adrenal Glands - drug effects</subject><subject>Adrenal Glands - metabolism</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Drug therapy</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mineralocorticoids - therapeutic use</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Vertebrates: endocrinology</subject><subject>Young Adult</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVtvEzEQhS0EoqHwF5AlhMrLBl931w-oqkJpkaqCuIU3y_GOhcPuOti7NPn3eEkIEg_4ZayZ74xG5yCEKZnT_F6u55SXsmCslHNGcpdwJcR8ew_NjoP7aEY4IQUpS3GCHqW0JoTImlQP0QnLS4SkfIa-vA6QcAQbfkLc4eCwaSL0psVu7O3gQ4-DtWPEvscbM3joh4Tv_PANm3EIvuvGHvBF0_gU-rOEcwWT4PwxeuBMm-DJoZ6iz28uPy2ui5t3V28XFzeFFaIWRd1AIxixVb6xcUDAOahoI4xiwoGQqjKVBEssVytOiXWmKsVqRV1JJAdW8lN0tt-7ieHHCGnQnU8W2tb0EMakaykVzQapTL74L0lFKSRhoiIZffYPug5jzJ5kSjIlS67URD09UOOqg0Zvou9M3Ok_3mbg-QEwyZrWRdNbn_5yXLGaKJq5V3vuzrewO84p0VPWeq2nSPUUqZ6y1r-z1lu9uLydfllf7PU-DbA96k38rsuKV1Ivb6_0x-v3H5ZL_lUv-C_x26pW</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Smans, Lisanne C. C. J.</creator><creator>Zelissen, Pierre M. J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Does recovery of adrenal function occur in patients with autoimmune Addison's disease?</title><author>Smans, Lisanne C. C. J. ; Zelissen, Pierre M. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4484-8ded420c7664dfe0effe71d4a924fe4597a75ec0c39b310cfa764bb1f6053e263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Addison Disease - blood</topic><topic>Addison Disease - drug therapy</topic><topic>Addison Disease - physiopathology</topic><topic>Adrenal glands</topic><topic>Adrenal Glands - drug effects</topic><topic>Adrenal Glands - metabolism</topic><topic>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Drug therapy</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mineralocorticoids - therapeutic use</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Vertebrates: endocrinology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smans, Lisanne C. C. J.</creatorcontrib><creatorcontrib>Zelissen, Pierre M. J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smans, Lisanne C. C. J.</au><au>Zelissen, Pierre M. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does recovery of adrenal function occur in patients with autoimmune Addison's disease?</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2011-04</date><risdate>2011</risdate><volume>74</volume><issue>4</issue><spage>434</spage><epage>437</epage><pages>434-437</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective We earlier discovered partial recovery in a patient with autoimmune Addison’s disease. The aim of this study was to assess the occurrence of adrenocortical recovery in patients with autoimmune adrenalitis.
Design Cross‐sectional study.
Patients Twenty‐seven adult patients with autoimmune Addison’s disease on stable glucocorticoid and mineralocorticoid replacement therapy (RT) attending the Department of Endocrinology of a university teaching hospital were included in this study.
Methods Adrenocortical function was assessed by performing an adrenocorticotrophic hormone (ACTH) (250 μg Synacthen) stimulation test (SST) after interruption of current glucocorticoid and mineralocorticoid RT. A normal adrenal response was defined as a serum cortisol concentration ≥500 nm 30 or 60 min after stimulation. Partial recovery was defined as a cortisol concentration ≥100 and ≤500 nm after stimulation.
Results In 17 patients (63%), serum cortisol concentrations remained undetectable 30 and 60 min after the administration of ACTH. None of the remaining 10 participants had a normal response. Only one patient reached a cortisol concentration of 100 nm after 60 min, but this could not be confirmed during a second SST.
Conclusions In this cross‐sectional study among 27 patients with autoimmune adrenalitis, no new cases of adrenocortical recovery were found.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21114513</pmid><doi>10.1111/j.1365-2265.2010.03944.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Addison Disease - blood Addison Disease - drug therapy Addison Disease - physiopathology Adrenal glands Adrenal Glands - drug effects Adrenal Glands - metabolism Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Adrenocorticotropic Hormone - pharmacology Adult Aged Biological and medical sciences Cross-Sectional Studies Drug therapy Endocrinopathies Female Fundamental and applied biological sciences. Psychology Glucocorticoids - therapeutic use Humans Hydrocortisone - blood Male Medical research Medical sciences Middle Aged Mineralocorticoids - therapeutic use Non tumoral diseases. Target tissue resistance. Benign neoplasms Vertebrates: endocrinology Young Adult |
| title | Does recovery of adrenal function occur in patients with autoimmune Addison's disease? |
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