Relation of Circulating Osteoprotegerin Levels on Admission to Microvascular Obstruction After Primary Percutaneous Coronary Intervention
Osteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily, has recently been linked to atherosclerosis and development of postinfarction heart failure. This study was designed to assess the association between admission OPG levels and microvascular obstruction (MVO) i...
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| Veröffentlicht in: | The American journal of cardiology 2011-03, Vol.107 (6), p.857-862 |
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| container_title | The American journal of cardiology |
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| creator | Erkol, Ayhan, MD Pala, Selcuk, MD Kırma, Cevat, MD Oduncu, Vecih, MD Dündar, Cihan, MD Izgi, Akın, MD Tigen, Kürsat, MD Gibson, C. Michael, MD, MS |
| description | Osteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily, has recently been linked to atherosclerosis and development of postinfarction heart failure. This study was designed to assess the association between admission OPG levels and microvascular obstruction (MVO) in patients who underwent primary percutaneous coronary intervention (p-PCI). Plasma samples for OPG analysis were obtained |
| doi_str_mv | 10.1016/j.amjcard.2010.10.071 |
| format | Article |
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Michael, MD, MS</creator><creatorcontrib>Erkol, Ayhan, MD ; Pala, Selcuk, MD ; Kırma, Cevat, MD ; Oduncu, Vecih, MD ; Dündar, Cihan, MD ; Izgi, Akın, MD ; Tigen, Kürsat, MD ; Gibson, C. Michael, MD, MS</creatorcontrib><description>Osteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily, has recently been linked to atherosclerosis and development of postinfarction heart failure. This study was designed to assess the association between admission OPG levels and microvascular obstruction (MVO) in patients who underwent primary percutaneous coronary intervention (p-PCI). Plasma samples for OPG analysis were obtained <30 minutes after admission in 47 patients who underwent p-PCI. Angiographic no-reflow (Thrombolysis In Myocardial Infarction [TIMI] flow grade <3 or 3 with myocardial blush grade 0 or 1 after p-PCI) was assessed immediately after p-PCI. MVO was assessed and quantified by the intracoronary hemodynamic measure of index of microcirculatory resistance performed on day 4 or 5 after p-PCI. Patients with angiographic no-reflow had significantly higher OPG levels on admission. On multiple linear regression analysis, OPG (β = 0.412, p = 0.001) and B-type natriuretic peptide (β = 0.409, p = 0.001) levels were independently and directly associated with the index of microcirculatory resistance. In conclusion, plasma OPG levels on admission are strongly associated with MVO and significantly correlated with the degree of MVO after p-PCI. It remains to be established whether improvement of microvascular perfusion is feasible with therapeutic strategies aimed to decrease circulating OPG levels.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2010.10.071</identifier><identifier>PMID: 21247537</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Angioplasty ; Angioplasty, Balloon, Coronary ; Biological and medical sciences ; Biomarkers - blood ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Chi-Square Distribution ; Coronary Angiography ; Coronary Circulation ; Diseases of the cardiovascular system ; Female ; Humans ; Linear Models ; Male ; Medical sciences ; Microcirculation ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - therapy ; Osteoprotegerin - blood ; Peptides ; Plasma ; Platelet Aggregation Inhibitors - administration & dosage ; Prospective Studies ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Regression analysis ; Statistics, Nonparametric ; Studies ; TNF inhibitors</subject><ispartof>The American journal of cardiology, 2011-03, Vol.107 (6), p.857-862</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Sequoia S.A. Mar 15, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-6fcc449aff945f8b16c60c64c4c61cdf23f74c9d0f796608be50aa5c135b393b3</citedby><cites>FETCH-LOGICAL-c476t-6fcc449aff945f8b16c60c64c4c61cdf23f74c9d0f796608be50aa5c135b393b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002914910024112$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23977449$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21247537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erkol, Ayhan, MD</creatorcontrib><creatorcontrib>Pala, Selcuk, MD</creatorcontrib><creatorcontrib>Kırma, Cevat, MD</creatorcontrib><creatorcontrib>Oduncu, Vecih, MD</creatorcontrib><creatorcontrib>Dündar, Cihan, MD</creatorcontrib><creatorcontrib>Izgi, Akın, MD</creatorcontrib><creatorcontrib>Tigen, Kürsat, MD</creatorcontrib><creatorcontrib>Gibson, C. Michael, MD, MS</creatorcontrib><title>Relation of Circulating Osteoprotegerin Levels on Admission to Microvascular Obstruction After Primary Percutaneous Coronary Intervention</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Osteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily, has recently been linked to atherosclerosis and development of postinfarction heart failure. This study was designed to assess the association between admission OPG levels and microvascular obstruction (MVO) in patients who underwent primary percutaneous coronary intervention (p-PCI). Plasma samples for OPG analysis were obtained <30 minutes after admission in 47 patients who underwent p-PCI. Angiographic no-reflow (Thrombolysis In Myocardial Infarction [TIMI] flow grade <3 or 3 with myocardial blush grade 0 or 1 after p-PCI) was assessed immediately after p-PCI. MVO was assessed and quantified by the intracoronary hemodynamic measure of index of microcirculatory resistance performed on day 4 or 5 after p-PCI. Patients with angiographic no-reflow had significantly higher OPG levels on admission. On multiple linear regression analysis, OPG (β = 0.412, p = 0.001) and B-type natriuretic peptide (β = 0.409, p = 0.001) levels were independently and directly associated with the index of microcirculatory resistance. In conclusion, plasma OPG levels on admission are strongly associated with MVO and significantly correlated with the degree of MVO after p-PCI. It remains to be established whether improvement of microvascular perfusion is feasible with therapeutic strategies aimed to decrease circulating OPG levels.</description><subject>Angioplasty</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Chi-Square Distribution</subject><subject>Coronary Angiography</subject><subject>Coronary Circulation</subject><subject>Diseases of the cardiovascular system</subject><subject>Female</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microcirculation</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - therapy</subject><subject>Osteoprotegerin - blood</subject><subject>Peptides</subject><subject>Plasma</subject><subject>Platelet Aggregation Inhibitors - administration & dosage</subject><subject>Prospective Studies</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Regression analysis</subject><subject>Statistics, Nonparametric</subject><subject>Studies</subject><subject>TNF inhibitors</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2L1DAUhoMo7rj6E5QiiFcdkzZJmxtlGPxYGJnFj-uQpidLaifZTdqB_Qn-a5PtuMLeeBVyeN4355w3CL0keE0w4e-GtToMWoV-XeG72ho35BFakbYRJRGkfoxWGOOqFISKM_QsxiFdCWH8KTqrSEUbVjcr9PsbjGqy3hXeFFsb9Jyv7qrYxwn8dfATXEGwrtjBEcZYJHDTH2yMWTL54qvVwR9VzLpQ7Ls4hVnf-W3MBKG4DPagwm1xCcl6Ug78HIutD97l6oVLzBFcFjxHT4waI7w4nefo56ePP7Zfyt3-88V2sys1bfhUcqM1pUIZIygzbUe45lhzqqnmRPemqk1DteixaQTnuO2AYaWYJjXralF39Tl6u_im4W5miJNM42gYx6U52TImcNO2PJGvH5CDn4NLzSVIsJpRXiWILVDaQ4wBjLxeRpYEy5yUHOQpKZmTyuWUVNK9OpnP3QH6e9XfaBLw5gSk7arRBOW0jf-4WjRNWkTiPixcigeOFoKM2oLT0NsAepK9t_9t5f0DBz1aZ9Ojv-AW4v3QRMZKYvk9f6v8q0g6KSFV_Qc9i8v4</recordid><startdate>20110315</startdate><enddate>20110315</enddate><creator>Erkol, Ayhan, MD</creator><creator>Pala, Selcuk, MD</creator><creator>Kırma, Cevat, MD</creator><creator>Oduncu, Vecih, MD</creator><creator>Dündar, Cihan, MD</creator><creator>Izgi, Akın, MD</creator><creator>Tigen, Kürsat, MD</creator><creator>Gibson, C. 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Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Chi-Square Distribution</topic><topic>Coronary Angiography</topic><topic>Coronary Circulation</topic><topic>Diseases of the cardiovascular system</topic><topic>Female</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microcirculation</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - therapy</topic><topic>Osteoprotegerin - blood</topic><topic>Peptides</topic><topic>Plasma</topic><topic>Platelet Aggregation Inhibitors - administration & dosage</topic><topic>Prospective Studies</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Michael, MD, MS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of Circulating Osteoprotegerin Levels on Admission to Microvascular Obstruction After Primary Percutaneous Coronary Intervention</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2011-03-15</date><risdate>2011</risdate><volume>107</volume><issue>6</issue><spage>857</spage><epage>862</epage><pages>857-862</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Osteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily, has recently been linked to atherosclerosis and development of postinfarction heart failure. This study was designed to assess the association between admission OPG levels and microvascular obstruction (MVO) in patients who underwent primary percutaneous coronary intervention (p-PCI). Plasma samples for OPG analysis were obtained <30 minutes after admission in 47 patients who underwent p-PCI. Angiographic no-reflow (Thrombolysis In Myocardial Infarction [TIMI] flow grade <3 or 3 with myocardial blush grade 0 or 1 after p-PCI) was assessed immediately after p-PCI. MVO was assessed and quantified by the intracoronary hemodynamic measure of index of microcirculatory resistance performed on day 4 or 5 after p-PCI. Patients with angiographic no-reflow had significantly higher OPG levels on admission. On multiple linear regression analysis, OPG (β = 0.412, p = 0.001) and B-type natriuretic peptide (β = 0.409, p = 0.001) levels were independently and directly associated with the index of microcirculatory resistance. In conclusion, plasma OPG levels on admission are strongly associated with MVO and significantly correlated with the degree of MVO after p-PCI. It remains to be established whether improvement of microvascular perfusion is feasible with therapeutic strategies aimed to decrease circulating OPG levels.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21247537</pmid><doi>10.1016/j.amjcard.2010.10.071</doi><tpages>6</tpages></addata></record> |
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| subjects | Angioplasty Angioplasty, Balloon, Coronary Biological and medical sciences Biomarkers - blood Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Chi-Square Distribution Coronary Angiography Coronary Circulation Diseases of the cardiovascular system Female Humans Linear Models Male Medical sciences Microcirculation Middle Aged Myocardial Infarction - blood Myocardial Infarction - diagnostic imaging Myocardial Infarction - therapy Osteoprotegerin - blood Peptides Plasma Platelet Aggregation Inhibitors - administration & dosage Prospective Studies Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Regression analysis Statistics, Nonparametric Studies TNF inhibitors |
| title | Relation of Circulating Osteoprotegerin Levels on Admission to Microvascular Obstruction After Primary Percutaneous Coronary Intervention |
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