The Effect of Low‐Level Laser Therapy as an Adjunct to Non‐Surgical Periodontal Treatment
Background: The aim of this study is to evaluate the effect of low‐level laser therapy (LLLT) as an adjunct to non‐surgical periodontal therapy of smoking and non‐smoking patients with moderate to advanced chronic periodontitis. Methods: All 36 systemically healthy patients who were included in the...
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| Veröffentlicht in: | Journal of periodontology (1970) 2011-03, Vol.82 (3), p.481-488 |
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| container_title | Journal of periodontology (1970) |
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| creator | Aykol, Gokce Baser, Ulku Maden, Ilay Kazak, Zafer Onan, Utku Tanrikulu‐Kucuk, Sevda Ademoglu, Evin Issever, Halim Yalcin, Funda |
| description | Background: The aim of this study is to evaluate the effect of low‐level laser therapy (LLLT) as an adjunct to non‐surgical periodontal therapy of smoking and non‐smoking patients with moderate to advanced chronic periodontitis.
Methods: All 36 systemically healthy patients who were included in the study initially received non‐surgical periodontal therapy. The LLLT group (n = 18) received GaAlAs diode laser therapy as an adjunct to non‐surgical periodontal therapy. A diode laser with a wavelength of 808 nm was used for the LLLT. Energy density of 4 J/cm2 was applied to the gingival surface after periodontal treatment on the first, second, and seventh days. Each of the LLLT and control groups was divided into two groups as smoking and non‐smoking patients to investigate the effect of smoking on treatment. Gingival crevicular fluid samples were collected from all patients and clinical parameters were recorded on baseline, the first, third, and sixth months after treatment. Matrix metalloproteinase‐1, tissue inhibitor matrix metalloproteinase‐1, transforming growth factor‐β1, and basic‐fibroblast growth factor levels in the collected gingival crevicular fluid were measured.
Results: The primary outcome variable in this study was change in gingival bleeding and inflammation. At all time points, the LLLT group showed significantly more improvement in sulcus bleeding index (SBI), clinical attachment level, and probing depth (PD) levels compared to the control group (P |
| doi_str_mv | 10.1902/jop.2010.100195 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_855904649</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>855904649</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4381-219cfa80882843dfdeaa8c152b0d3c90c5035298ba4cb214c7b4f63d97ff7ec63</originalsourceid><addsrcrecordid>eNqFkMtu1DAUhi0EokNhzQ55g1ilPb4ksZdVNVyqqFRlWCLLcY4ho0w82AnV7HgEnpEnqUczhWVX9i9__o_OR8hrBmdMAz9fh-0Zh30CYLp8QhZMS1GIqoanZAHAeSGk5ifkRUrrHJkU8JyccNCCs7JekG-rH0iX3qObaPC0CXd_f_9p8BcOtLEJI83v0W531CZqR3rRrecxo1Og12HM6Jc5fu-dHegNxj50YZzyfRXRThscp5fkmbdDwlfH85R8fb9cXX4sms8fPl1eNIWTQrGCM-28VaAUV1J0vkNrlWMlb6ETToMrQZRcq9ZK1-YdXN1KX4lO197X6CpxSt4dercx_JwxTWbTJ4fDYEcMczKqLDXISupMnh9IF0NKEb3Zxn5j484wMHulJis1e6XmoDT_eHPsntsNdv_4B4cZeHsEbMomfLSj69N_Tui6rmBfVB64u37A3WNzzdXN8hakYuIeXOGQeQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>855904649</pqid></control><display><type>article</type><title>The Effect of Low‐Level Laser Therapy as an Adjunct to Non‐Surgical Periodontal Treatment</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Aykol, Gokce ; Baser, Ulku ; Maden, Ilay ; Kazak, Zafer ; Onan, Utku ; Tanrikulu‐Kucuk, Sevda ; Ademoglu, Evin ; Issever, Halim ; Yalcin, Funda</creator><creatorcontrib>Aykol, Gokce ; Baser, Ulku ; Maden, Ilay ; Kazak, Zafer ; Onan, Utku ; Tanrikulu‐Kucuk, Sevda ; Ademoglu, Evin ; Issever, Halim ; Yalcin, Funda</creatorcontrib><description>Background: The aim of this study is to evaluate the effect of low‐level laser therapy (LLLT) as an adjunct to non‐surgical periodontal therapy of smoking and non‐smoking patients with moderate to advanced chronic periodontitis.
Methods: All 36 systemically healthy patients who were included in the study initially received non‐surgical periodontal therapy. The LLLT group (n = 18) received GaAlAs diode laser therapy as an adjunct to non‐surgical periodontal therapy. A diode laser with a wavelength of 808 nm was used for the LLLT. Energy density of 4 J/cm2 was applied to the gingival surface after periodontal treatment on the first, second, and seventh days. Each of the LLLT and control groups was divided into two groups as smoking and non‐smoking patients to investigate the effect of smoking on treatment. Gingival crevicular fluid samples were collected from all patients and clinical parameters were recorded on baseline, the first, third, and sixth months after treatment. Matrix metalloproteinase‐1, tissue inhibitor matrix metalloproteinase‐1, transforming growth factor‐β1, and basic‐fibroblast growth factor levels in the collected gingival crevicular fluid were measured.
Results: The primary outcome variable in this study was change in gingival bleeding and inflammation. At all time points, the LLLT group showed significantly more improvement in sulcus bleeding index (SBI), clinical attachment level, and probing depth (PD) levels compared to the control group (P <0.001). There were clinically significant improvements in the laser‐applied smokers' PD and SBI levels compared to smokers to whom a laser was not applied, between the baseline and all time points (P <0.001) (SBI score: control group 1.12, LLLT group 1.49; PD: control group 1.21 mm, LLLT group 1.46 mm, between baseline and 6 months). Transforming growth factor‐β1 levels and the ratio of matrix metalloproteinase‐1 to tissue inhibitor matrix metalloproteinase‐1 decreased significantly in both groups at 1, 3, and 6 months after periodontal therapy (P <0.001). Basic‐fibroblast growth factor levels significantly decreased in both groups in the first month after the treatment, then increased in the third and sixth months (P <0.005). No marker level change showed significant differences between the groups (P <0.05).
Conclusion: LLLT as an adjunctive therapy to non‐surgical periodontal treatment improves periodontal healing.</description><identifier>ISSN: 0022-3492</identifier><identifier>EISSN: 1943-3670</identifier><identifier>DOI: 10.1902/jop.2010.100195</identifier><identifier>PMID: 20932157</identifier><language>eng</language><publisher>Chicago, IL: American Academy of Periodontology</publisher><subject>Adult ; Biological and medical sciences ; Chronic Periodontitis - pathology ; Chronic Periodontitis - radiotherapy ; Chronic Periodontitis - therapy ; Dental Scaling ; Dentistry ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; Fibroblast Growth Factor 2 - analysis ; Gingival Crevicular Fluid - chemistry ; Humans ; laser therapy, low level ; Lasers, Semiconductor - therapeutic use ; Low-Level Light Therapy ; Male ; Matrix Metalloproteinase 1 - analysis ; matrix metalloproteinase‐1 ; Medical sciences ; Middle Aged ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Periodontal Index ; periodontitis ; Radiotherapy, Adjuvant ; root planing ; Smoking ; Statistics, Nonparametric ; Tissue Inhibitor of Metalloproteinase-1 - analysis ; Tobacco, tobacco smoking ; Toxicology ; Transforming Growth Factor beta1 - analysis ; Wound Healing - radiation effects</subject><ispartof>Journal of periodontology (1970), 2011-03, Vol.82 (3), p.481-488</ispartof><rights>2011 American Academy of Periodontology</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4381-219cfa80882843dfdeaa8c152b0d3c90c5035298ba4cb214c7b4f63d97ff7ec63</citedby><cites>FETCH-LOGICAL-c4381-219cfa80882843dfdeaa8c152b0d3c90c5035298ba4cb214c7b4f63d97ff7ec63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1902%2Fjop.2010.100195$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1902%2Fjop.2010.100195$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23977605$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20932157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aykol, Gokce</creatorcontrib><creatorcontrib>Baser, Ulku</creatorcontrib><creatorcontrib>Maden, Ilay</creatorcontrib><creatorcontrib>Kazak, Zafer</creatorcontrib><creatorcontrib>Onan, Utku</creatorcontrib><creatorcontrib>Tanrikulu‐Kucuk, Sevda</creatorcontrib><creatorcontrib>Ademoglu, Evin</creatorcontrib><creatorcontrib>Issever, Halim</creatorcontrib><creatorcontrib>Yalcin, Funda</creatorcontrib><title>The Effect of Low‐Level Laser Therapy as an Adjunct to Non‐Surgical Periodontal Treatment</title><title>Journal of periodontology (1970)</title><addtitle>J Periodontol</addtitle><description>Background: The aim of this study is to evaluate the effect of low‐level laser therapy (LLLT) as an adjunct to non‐surgical periodontal therapy of smoking and non‐smoking patients with moderate to advanced chronic periodontitis.
Methods: All 36 systemically healthy patients who were included in the study initially received non‐surgical periodontal therapy. The LLLT group (n = 18) received GaAlAs diode laser therapy as an adjunct to non‐surgical periodontal therapy. A diode laser with a wavelength of 808 nm was used for the LLLT. Energy density of 4 J/cm2 was applied to the gingival surface after periodontal treatment on the first, second, and seventh days. Each of the LLLT and control groups was divided into two groups as smoking and non‐smoking patients to investigate the effect of smoking on treatment. Gingival crevicular fluid samples were collected from all patients and clinical parameters were recorded on baseline, the first, third, and sixth months after treatment. Matrix metalloproteinase‐1, tissue inhibitor matrix metalloproteinase‐1, transforming growth factor‐β1, and basic‐fibroblast growth factor levels in the collected gingival crevicular fluid were measured.
Results: The primary outcome variable in this study was change in gingival bleeding and inflammation. At all time points, the LLLT group showed significantly more improvement in sulcus bleeding index (SBI), clinical attachment level, and probing depth (PD) levels compared to the control group (P <0.001). There were clinically significant improvements in the laser‐applied smokers' PD and SBI levels compared to smokers to whom a laser was not applied, between the baseline and all time points (P <0.001) (SBI score: control group 1.12, LLLT group 1.49; PD: control group 1.21 mm, LLLT group 1.46 mm, between baseline and 6 months). Transforming growth factor‐β1 levels and the ratio of matrix metalloproteinase‐1 to tissue inhibitor matrix metalloproteinase‐1 decreased significantly in both groups at 1, 3, and 6 months after periodontal therapy (P <0.001). Basic‐fibroblast growth factor levels significantly decreased in both groups in the first month after the treatment, then increased in the third and sixth months (P <0.005). No marker level change showed significant differences between the groups (P <0.05).
Conclusion: LLLT as an adjunctive therapy to non‐surgical periodontal treatment improves periodontal healing.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chronic Periodontitis - pathology</subject><subject>Chronic Periodontitis - radiotherapy</subject><subject>Chronic Periodontitis - therapy</subject><subject>Dental Scaling</subject><subject>Dentistry</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Female</subject><subject>Fibroblast Growth Factor 2 - analysis</subject><subject>Gingival Crevicular Fluid - chemistry</subject><subject>Humans</subject><subject>laser therapy, low level</subject><subject>Lasers, Semiconductor - therapeutic use</subject><subject>Low-Level Light Therapy</subject><subject>Male</subject><subject>Matrix Metalloproteinase 1 - analysis</subject><subject>matrix metalloproteinase‐1</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Periodontal Index</subject><subject>periodontitis</subject><subject>Radiotherapy, Adjuvant</subject><subject>root planing</subject><subject>Smoking</subject><subject>Statistics, Nonparametric</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - analysis</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><subject>Transforming Growth Factor beta1 - analysis</subject><subject>Wound Healing - radiation effects</subject><issn>0022-3492</issn><issn>1943-3670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtu1DAUhi0EokNhzQ55g1ilPb4ksZdVNVyqqFRlWCLLcY4ho0w82AnV7HgEnpEnqUczhWVX9i9__o_OR8hrBmdMAz9fh-0Zh30CYLp8QhZMS1GIqoanZAHAeSGk5ifkRUrrHJkU8JyccNCCs7JekG-rH0iX3qObaPC0CXd_f_9p8BcOtLEJI83v0W531CZqR3rRrecxo1Og12HM6Jc5fu-dHegNxj50YZzyfRXRThscp5fkmbdDwlfH85R8fb9cXX4sms8fPl1eNIWTQrGCM-28VaAUV1J0vkNrlWMlb6ETToMrQZRcq9ZK1-YdXN1KX4lO197X6CpxSt4dercx_JwxTWbTJ4fDYEcMczKqLDXISupMnh9IF0NKEb3Zxn5j484wMHulJis1e6XmoDT_eHPsntsNdv_4B4cZeHsEbMomfLSj69N_Tui6rmBfVB64u37A3WNzzdXN8hakYuIeXOGQeQ</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Aykol, Gokce</creator><creator>Baser, Ulku</creator><creator>Maden, Ilay</creator><creator>Kazak, Zafer</creator><creator>Onan, Utku</creator><creator>Tanrikulu‐Kucuk, Sevda</creator><creator>Ademoglu, Evin</creator><creator>Issever, Halim</creator><creator>Yalcin, Funda</creator><general>American Academy of Periodontology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201103</creationdate><title>The Effect of Low‐Level Laser Therapy as an Adjunct to Non‐Surgical Periodontal Treatment</title><author>Aykol, Gokce ; Baser, Ulku ; Maden, Ilay ; Kazak, Zafer ; Onan, Utku ; Tanrikulu‐Kucuk, Sevda ; Ademoglu, Evin ; Issever, Halim ; Yalcin, Funda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4381-219cfa80882843dfdeaa8c152b0d3c90c5035298ba4cb214c7b4f63d97ff7ec63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chronic Periodontitis - pathology</topic><topic>Chronic Periodontitis - radiotherapy</topic><topic>Chronic Periodontitis - therapy</topic><topic>Dental Scaling</topic><topic>Dentistry</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Female</topic><topic>Fibroblast Growth Factor 2 - analysis</topic><topic>Gingival Crevicular Fluid - chemistry</topic><topic>Humans</topic><topic>laser therapy, low level</topic><topic>Lasers, Semiconductor - therapeutic use</topic><topic>Low-Level Light Therapy</topic><topic>Male</topic><topic>Matrix Metalloproteinase 1 - analysis</topic><topic>matrix metalloproteinase‐1</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Periodontal Index</topic><topic>periodontitis</topic><topic>Radiotherapy, Adjuvant</topic><topic>root planing</topic><topic>Smoking</topic><topic>Statistics, Nonparametric</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - analysis</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><topic>Transforming Growth Factor beta1 - analysis</topic><topic>Wound Healing - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aykol, Gokce</creatorcontrib><creatorcontrib>Baser, Ulku</creatorcontrib><creatorcontrib>Maden, Ilay</creatorcontrib><creatorcontrib>Kazak, Zafer</creatorcontrib><creatorcontrib>Onan, Utku</creatorcontrib><creatorcontrib>Tanrikulu‐Kucuk, Sevda</creatorcontrib><creatorcontrib>Ademoglu, Evin</creatorcontrib><creatorcontrib>Issever, Halim</creatorcontrib><creatorcontrib>Yalcin, Funda</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontology (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aykol, Gokce</au><au>Baser, Ulku</au><au>Maden, Ilay</au><au>Kazak, Zafer</au><au>Onan, Utku</au><au>Tanrikulu‐Kucuk, Sevda</au><au>Ademoglu, Evin</au><au>Issever, Halim</au><au>Yalcin, Funda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Low‐Level Laser Therapy as an Adjunct to Non‐Surgical Periodontal Treatment</atitle><jtitle>Journal of periodontology (1970)</jtitle><addtitle>J Periodontol</addtitle><date>2011-03</date><risdate>2011</risdate><volume>82</volume><issue>3</issue><spage>481</spage><epage>488</epage><pages>481-488</pages><issn>0022-3492</issn><eissn>1943-3670</eissn><abstract>Background: The aim of this study is to evaluate the effect of low‐level laser therapy (LLLT) as an adjunct to non‐surgical periodontal therapy of smoking and non‐smoking patients with moderate to advanced chronic periodontitis.
Methods: All 36 systemically healthy patients who were included in the study initially received non‐surgical periodontal therapy. The LLLT group (n = 18) received GaAlAs diode laser therapy as an adjunct to non‐surgical periodontal therapy. A diode laser with a wavelength of 808 nm was used for the LLLT. Energy density of 4 J/cm2 was applied to the gingival surface after periodontal treatment on the first, second, and seventh days. Each of the LLLT and control groups was divided into two groups as smoking and non‐smoking patients to investigate the effect of smoking on treatment. Gingival crevicular fluid samples were collected from all patients and clinical parameters were recorded on baseline, the first, third, and sixth months after treatment. Matrix metalloproteinase‐1, tissue inhibitor matrix metalloproteinase‐1, transforming growth factor‐β1, and basic‐fibroblast growth factor levels in the collected gingival crevicular fluid were measured.
Results: The primary outcome variable in this study was change in gingival bleeding and inflammation. At all time points, the LLLT group showed significantly more improvement in sulcus bleeding index (SBI), clinical attachment level, and probing depth (PD) levels compared to the control group (P <0.001). There were clinically significant improvements in the laser‐applied smokers' PD and SBI levels compared to smokers to whom a laser was not applied, between the baseline and all time points (P <0.001) (SBI score: control group 1.12, LLLT group 1.49; PD: control group 1.21 mm, LLLT group 1.46 mm, between baseline and 6 months). Transforming growth factor‐β1 levels and the ratio of matrix metalloproteinase‐1 to tissue inhibitor matrix metalloproteinase‐1 decreased significantly in both groups at 1, 3, and 6 months after periodontal therapy (P <0.001). Basic‐fibroblast growth factor levels significantly decreased in both groups in the first month after the treatment, then increased in the third and sixth months (P <0.005). No marker level change showed significant differences between the groups (P <0.05).
Conclusion: LLLT as an adjunctive therapy to non‐surgical periodontal treatment improves periodontal healing.</abstract><cop>Chicago, IL</cop><pub>American Academy of Periodontology</pub><pmid>20932157</pmid><doi>10.1902/jop.2010.100195</doi><tpages>8</tpages></addata></record> |
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| language | eng |
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| subjects | Adult Biological and medical sciences Chronic Periodontitis - pathology Chronic Periodontitis - radiotherapy Chronic Periodontitis - therapy Dental Scaling Dentistry Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Fibroblast Growth Factor 2 - analysis Gingival Crevicular Fluid - chemistry Humans laser therapy, low level Lasers, Semiconductor - therapeutic use Low-Level Light Therapy Male Matrix Metalloproteinase 1 - analysis matrix metalloproteinase‐1 Medical sciences Middle Aged Non tumoral diseases Otorhinolaryngology. Stomatology Periodontal Index periodontitis Radiotherapy, Adjuvant root planing Smoking Statistics, Nonparametric Tissue Inhibitor of Metalloproteinase-1 - analysis Tobacco, tobacco smoking Toxicology Transforming Growth Factor beta1 - analysis Wound Healing - radiation effects |
| title | The Effect of Low‐Level Laser Therapy as an Adjunct to Non‐Surgical Periodontal Treatment |
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