Cavitation-enhanced delivery of macromolecules into an obstructed vessel
Poor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The aim of this study was to examine the ability of cavitation instigated by high-intensity focused ultrasound (HIFU) to increase convective transport of a model therapeutic in an in vitro tumor model...
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| Veröffentlicht in: | The Journal of the Acoustical Society of America 2010-11, Vol.128 (5), p.EL310-EL315 |
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| container_end_page | EL315 |
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| container_issue | 5 |
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| container_title | The Journal of the Acoustical Society of America |
| container_volume | 128 |
| creator | Rifai, Bassel Arvanitis, Costas D. Bazan-Peregrino, Miriam Coussios, Constantin-C. |
| description | Poor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The aim of this study was to examine the ability of cavitation instigated by high-intensity focused ultrasound (HIFU) to increase convective transport of a model therapeutic in an
in vitro
tumor model. Cavitation activity was quantified by analyzing passively recorded acoustic emissions, and mass transfer was quantified using post-treatment image analysis of the distribution of a dye-labeled macromolecule. The strong correlation between cavitation activity and drug delivery suggests the potential for non-invasive treatment and monitoring. |
| doi_str_mv | 10.1121/1.3496388 |
| format | Article |
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in vitro
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The strong correlation between cavitation activity and drug delivery suggests the potential for non-invasive treatment and monitoring.</description><subject>Acoustics</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Arterial Occlusive Diseases - diagnostic imaging</subject><subject>Cavitation</subject><subject>Correlation</subject><subject>Drug delivery systems</subject><subject>Drug Delivery Systems - methods</subject><subject>Drugs</subject><subject>Exact sciences and technology</subject><subject>Fundamental areas of phenomenology (including applications)</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Macromolecular Substances - pharmacokinetics</subject><subject>Macromolecules</subject><subject>Mass transfer</subject><subject>Models, Biological</subject><subject>Neoplasms - blood supply</subject><subject>Neoplasms - diagnostic imaging</subject><subject>Neoplasms - drug therapy</subject><subject>Obstacles</subject><subject>Physics</subject><subject>Therapy</subject><subject>Tumor Microenvironment</subject><subject>Tumors</subject><subject>Ultrasonic Therapy - methods</subject><subject>Ultrasonography</subject><subject>Underwater sound</subject><issn>0001-4966</issn><issn>1520-8524</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c9LwzAUB_AgipvTg_-A9CLioTMvP9r04EGGOmHgRc8lTV-w0h8zaQf7742scyfxlIR88h75PkIugc4BGNzBnIss4UodkSlIRmMlmTgmU0opxOEmmZAz7z_DUSqenZIJAwAqhZiS5UJvql73VdfG2H7o1mAZlVhXG3TbqLNRo43rmq5GM9Too6rtu0i3UVf43g2mD3qD3mN9Tk6srj1ejOuMvD89vi2W8er1-WXxsIqN4LKPDVeCp4kpIC0oE7TkmU1KC0wlVmfKSl2iQpUKFraUZqmVAqwOD2iRMoZ8Rm52ddeu-xrQ93lTeYN1rVvsBp8rKVNGBbD_JUgpUspkkLc7Gb7qvUObr13VaLfNgeY_CeeQjwkHezVWHYoGy1-5jzSA6xFob3RtXci08gfHE5XQjAZ3v3PejAP4u-thSPl-SPwbYRqXGw</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Rifai, Bassel</creator><creator>Arvanitis, Costas D.</creator><creator>Bazan-Peregrino, Miriam</creator><creator>Coussios, Constantin-C.</creator><general>Acoustical Society of America</general><general>American Institute of Physics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20101101</creationdate><title>Cavitation-enhanced delivery of macromolecules into an obstructed vessel</title><author>Rifai, Bassel ; 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in vitro
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| identifier | ISSN: 0001-4966 |
| ispartof | The Journal of the Acoustical Society of America, 2010-11, Vol.128 (5), p.EL310-EL315 |
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| language | eng |
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| source | MEDLINE; AIP Journals Complete; Alma/SFX Local Collection; AIP Acoustical Society of America |
| subjects | Acoustics Antineoplastic Agents - pharmacokinetics Arterial Occlusive Diseases - diagnostic imaging Cavitation Correlation Drug delivery systems Drug Delivery Systems - methods Drugs Exact sciences and technology Fundamental areas of phenomenology (including applications) Humans In Vitro Techniques Macromolecular Substances - pharmacokinetics Macromolecules Mass transfer Models, Biological Neoplasms - blood supply Neoplasms - diagnostic imaging Neoplasms - drug therapy Obstacles Physics Therapy Tumor Microenvironment Tumors Ultrasonic Therapy - methods Ultrasonography Underwater sound |
| title | Cavitation-enhanced delivery of macromolecules into an obstructed vessel |
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