Thermal stability of aripiprazole monohydrate investigated by Raman spectroscopy

Aripiprazole (7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril) is a well-known antipsychotic oral drug, whose molecular structure makes it suitable for polymorphism. Several crystalline structures were reported in the literature including anhydrate, hydrate and solvate modi...

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Veröffentlicht in:	Vibrational spectroscopy 2010-11, Vol.54 (2), p.169-173
Hauptverfasser:	Ayala, Alejandro Pedro, Honorato, Sara Braga, Filho, Josué Mendes, Grillo, Damián, Quintero, Mariano, Gilles, Facundo, Polla, Griselda
Format:	Artikel
Sprache:	eng
Schlagworte:	Aripiprazole Dehydration Diffusion rate Drugs Hydrate Hydrates Molecular structure Nucleation Principal component analysis Raman scattering Stability Statistical methods Thermal analysis
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