Human plasma quantification of droperidol and ondansetron used in preventing postoperative nausea and vomiting with a LC/ESI/MS/MS method

An analytical method based upon liquid chromatography coupled to ion trap mass spectrometry (MS) detection with electrospray ionization interface has been developed for the simultaneous identification and quantification of droperidol and ondansetron in human plasma. The two drugs were isolated from...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2011-01, Vol.879 (2), p.186-190
Hauptverfasser:	Alvarez, Jean-Claude, Charbit, Beny, Grassin-Delyle, Stanislas, Demolis, Jean-Louis, Funck-Brentano, Christian, Abe, Emuri
Format:	Artikel
Sprache:	eng
Schlagworte:	acetonitrile Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences blood plasma Chromatography, Liquid - methods detection limit Droperidol Droperidol - blood Droperidol - therapeutic use Elution Fundamental and applied biological sciences. Psychology General pharmacology haloperidol heptane Human Human plasma Humans Ionization LC/ESI/MS/MS Linear Models Liquid chromatography Liquid-liquid extraction Medical sciences Nausea Ondansetron Ondansetron - blood Ondansetron - therapeutic use Pharmacology. Drug treatments Postoperative nausea and vomiting Postoperative Nausea and Vomiting - blood Postoperative Nausea and Vomiting - drug therapy Recovery Reproducibility of Results Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - methods tandem mass spectrometry Tandem Mass Spectrometry - methods Vomiting
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