Arabidopsis Type I Metacaspases Control Cell Death
Metacaspases are distant relatives of animal caspases found in protozoa, fungi, and plants. Limited experimental data exist defining their function(s), despite their discovery by homology modeling a decade ago. We demonstrated that two type I metacaspases, AtMC1 and AtMC2, antagonistically control p...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2010-12, Vol.330 (6009), p.1393-1397 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Coll, Nuria S Vercammen, Dominique Smidler, Andrea Clover, Charles Van Breusegem, Frank Dangl, Jeffery L Epple, Petra |
| description | Metacaspases are distant relatives of animal caspases found in protozoa, fungi, and plants. Limited experimental data exist defining their function(s), despite their discovery by homology modeling a decade ago. We demonstrated that two type I metacaspases, AtMC1 and AtMC2, antagonistically control programmed cell death in ARABIDOPSIS: AtMC1 is a positive regulator of cell death and requires conserved caspase-like putative catalytic residues for its function. AtMC2 negatively regulates cell death. This function is independent of the putative catalytic residues. Manipulation of the Arabidopsis type I metacaspase regulatory module can nearly eliminate the hypersensitive cell death response (HR) activated by plant intracellular immune receptors. This does not lead to enhanced pathogen proliferation, decoupling HR from restriction of pathogen growth. |
| doi_str_mv | 10.1126/science.1194980 |
| format | Article |
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Limited experimental data exist defining their function(s), despite their discovery by homology modeling a decade ago. We demonstrated that two type I metacaspases, AtMC1 and AtMC2, antagonistically control programmed cell death in ARABIDOPSIS: AtMC1 is a positive regulator of cell death and requires conserved caspase-like putative catalytic residues for its function. AtMC2 negatively regulates cell death. This function is independent of the putative catalytic residues. Manipulation of the Arabidopsis type I metacaspase regulatory module can nearly eliminate the hypersensitive cell death response (HR) activated by plant intracellular immune receptors. This does not lead to enhanced pathogen proliferation, decoupling HR from restriction of pathogen growth.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1194980</identifier><identifier>PMID: 21097903</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Apoptosis ; Arabidopsis - enzymology ; Arabidopsis - immunology ; Arabidopsis - microbiology ; Arabidopsis - physiology ; Arabidopsis Proteins - chemistry ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Biological and medical sciences ; Caspases - chemistry ; Caspases - genetics ; Caspases - metabolism ; Catalysis ; Catalysts ; Cell death ; Cotyledons ; Decoupling ; DNA-Binding Proteins - chemistry ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Fundamental and applied biological sciences. Psychology ; Genotypes ; Mathematical models ; Mutation ; Oomycetes - physiology ; Pathogens ; Physiological regulation ; Phytopathology. Animal pests. Plant and forest protection ; Plant Diseases - immunology ; Plant Diseases - microbiology ; Plants ; Plants, Genetically Modified ; Proteins ; Protozoa ; Pseudomonas syringae - physiology ; Receptors ; Regulators ; Residues ; Seedlings ; Transcription Factors - chemistry ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transgenic plants ; Zinc Fingers</subject><ispartof>Science (American Association for the Advancement of Science), 2010-12, Vol.330 (6009), p.1393-1397</ispartof><rights>Copyright © 2010 American Association for the Advancement of Science</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-8bf122d2ca210f494b0415fe348e036b6f97f054b43454b284c1dd7621f240c13</citedby><cites>FETCH-LOGICAL-c478t-8bf122d2ca210f494b0415fe348e036b6f97f054b43454b284c1dd7621f240c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40963985$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40963985$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23669683$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21097903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coll, Nuria S</creatorcontrib><creatorcontrib>Vercammen, Dominique</creatorcontrib><creatorcontrib>Smidler, Andrea</creatorcontrib><creatorcontrib>Clover, Charles</creatorcontrib><creatorcontrib>Van Breusegem, Frank</creatorcontrib><creatorcontrib>Dangl, Jeffery L</creatorcontrib><creatorcontrib>Epple, Petra</creatorcontrib><title>Arabidopsis Type I Metacaspases Control Cell Death</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Metacaspases are distant relatives of animal caspases found in protozoa, fungi, and plants. Limited experimental data exist defining their function(s), despite their discovery by homology modeling a decade ago. We demonstrated that two type I metacaspases, AtMC1 and AtMC2, antagonistically control programmed cell death in ARABIDOPSIS: AtMC1 is a positive regulator of cell death and requires conserved caspase-like putative catalytic residues for its function. AtMC2 negatively regulates cell death. This function is independent of the putative catalytic residues. Manipulation of the Arabidopsis type I metacaspase regulatory module can nearly eliminate the hypersensitive cell death response (HR) activated by plant intracellular immune receptors. This does not lead to enhanced pathogen proliferation, decoupling HR from restriction of pathogen growth.</description><subject>Apoptosis</subject><subject>Arabidopsis - enzymology</subject><subject>Arabidopsis - immunology</subject><subject>Arabidopsis - microbiology</subject><subject>Arabidopsis - physiology</subject><subject>Arabidopsis Proteins - chemistry</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Biological and medical sciences</subject><subject>Caspases - chemistry</subject><subject>Caspases - genetics</subject><subject>Caspases - metabolism</subject><subject>Catalysis</subject><subject>Catalysts</subject><subject>Cell death</subject><subject>Cotyledons</subject><subject>Decoupling</subject><subject>DNA-Binding Proteins - chemistry</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotypes</subject><subject>Mathematical models</subject><subject>Mutation</subject><subject>Oomycetes - physiology</subject><subject>Pathogens</subject><subject>Physiological regulation</subject><subject>Phytopathology. Animal pests. Plant and forest protection</subject><subject>Plant Diseases - immunology</subject><subject>Plant Diseases - microbiology</subject><subject>Plants</subject><subject>Plants, Genetically Modified</subject><subject>Proteins</subject><subject>Protozoa</subject><subject>Pseudomonas syringae - physiology</subject><subject>Receptors</subject><subject>Regulators</subject><subject>Residues</subject><subject>Seedlings</subject><subject>Transcription Factors - chemistry</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transgenic plants</subject><subject>Zinc Fingers</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0DtP5DAUBWALgWAWqKmANGhpAtdvu0TDLiCBKIA6chx7CcpMgm-m4N9jNFnooLFlnc_X1iHkgMIZpUydo2_D0od8sMIa2CAzClaWlgHfJDMArkoDWu6QX4gvADmzfJvssKy0BT4j7CK5um36AVssHt-GUNwUd2F03uHgMGAx75dj6rtiHrquuAxufN4jW9F1GPanfZc8_f3zOL8ub--vbuYXt6UX2oylqSNlrGHe5deisKIGQWUMXJiQ_1WraHUEKWrBRV6ZEZ42jVaMRibAU75Lfq_nDql_XQUcq0WLPn_DLUO_wspIqYzV2vwsqbRKGsOyPP1WUqWpNEwznen5mvrUI6YQqyG1C5feKgrVR_nVVH41lZ9vHE3DV_UiNJ_-f9sZnEzAoXddTG7pW_xyXCmrzIc7XLsXHPv0mQuwilsjc368zqPrK_cv5RlPDwwoB2qpzjXzd4MtnW8</recordid><startdate>20101203</startdate><enddate>20101203</enddate><creator>Coll, Nuria S</creator><creator>Vercammen, Dominique</creator><creator>Smidler, Andrea</creator><creator>Clover, Charles</creator><creator>Van Breusegem, Frank</creator><creator>Dangl, Jeffery L</creator><creator>Epple, Petra</creator><general>American Association for the Advancement of Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20101203</creationdate><title>Arabidopsis Type I Metacaspases Control Cell Death</title><author>Coll, Nuria S ; Vercammen, Dominique ; Smidler, Andrea ; Clover, Charles ; Van Breusegem, Frank ; Dangl, Jeffery L ; Epple, Petra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-8bf122d2ca210f494b0415fe348e036b6f97f054b43454b284c1dd7621f240c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Apoptosis</topic><topic>Arabidopsis - enzymology</topic><topic>Arabidopsis - immunology</topic><topic>Arabidopsis - microbiology</topic><topic>Arabidopsis - physiology</topic><topic>Arabidopsis Proteins - chemistry</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Biological and medical sciences</topic><topic>Caspases - chemistry</topic><topic>Caspases - genetics</topic><topic>Caspases - metabolism</topic><topic>Catalysis</topic><topic>Catalysts</topic><topic>Cell death</topic><topic>Cotyledons</topic><topic>Decoupling</topic><topic>DNA-Binding Proteins - chemistry</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotypes</topic><topic>Mathematical models</topic><topic>Mutation</topic><topic>Oomycetes - physiology</topic><topic>Pathogens</topic><topic>Physiological regulation</topic><topic>Phytopathology. Animal pests. Plant and forest protection</topic><topic>Plant Diseases - immunology</topic><topic>Plant Diseases - microbiology</topic><topic>Plants</topic><topic>Plants, Genetically Modified</topic><topic>Proteins</topic><topic>Protozoa</topic><topic>Pseudomonas syringae - physiology</topic><topic>Receptors</topic><topic>Regulators</topic><topic>Residues</topic><topic>Seedlings</topic><topic>Transcription Factors - chemistry</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Transgenic plants</topic><topic>Zinc Fingers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coll, Nuria S</creatorcontrib><creatorcontrib>Vercammen, Dominique</creatorcontrib><creatorcontrib>Smidler, Andrea</creatorcontrib><creatorcontrib>Clover, Charles</creatorcontrib><creatorcontrib>Van Breusegem, Frank</creatorcontrib><creatorcontrib>Dangl, Jeffery L</creatorcontrib><creatorcontrib>Epple, Petra</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coll, Nuria S</au><au>Vercammen, Dominique</au><au>Smidler, Andrea</au><au>Clover, Charles</au><au>Van Breusegem, Frank</au><au>Dangl, Jeffery L</au><au>Epple, Petra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arabidopsis Type I Metacaspases Control Cell Death</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2010-12-03</date><risdate>2010</risdate><volume>330</volume><issue>6009</issue><spage>1393</spage><epage>1397</epage><pages>1393-1397</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Metacaspases are distant relatives of animal caspases found in protozoa, fungi, and plants. Limited experimental data exist defining their function(s), despite their discovery by homology modeling a decade ago. We demonstrated that two type I metacaspases, AtMC1 and AtMC2, antagonistically control programmed cell death in ARABIDOPSIS: AtMC1 is a positive regulator of cell death and requires conserved caspase-like putative catalytic residues for its function. AtMC2 negatively regulates cell death. This function is independent of the putative catalytic residues. Manipulation of the Arabidopsis type I metacaspase regulatory module can nearly eliminate the hypersensitive cell death response (HR) activated by plant intracellular immune receptors. This does not lead to enhanced pathogen proliferation, decoupling HR from restriction of pathogen growth.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>21097903</pmid><doi>10.1126/science.1194980</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Apoptosis Arabidopsis - enzymology Arabidopsis - immunology Arabidopsis - microbiology Arabidopsis - physiology Arabidopsis Proteins - chemistry Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Biological and medical sciences Caspases - chemistry Caspases - genetics Caspases - metabolism Catalysis Catalysts Cell death Cotyledons Decoupling DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Genotypes Mathematical models Mutation Oomycetes - physiology Pathogens Physiological regulation Phytopathology. Animal pests. Plant and forest protection Plant Diseases - immunology Plant Diseases - microbiology Plants Plants, Genetically Modified Proteins Protozoa Pseudomonas syringae - physiology Receptors Regulators Residues Seedlings Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transgenic plants Zinc Fingers |
| title | Arabidopsis Type I Metacaspases Control Cell Death |
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