Enhanced gene transfection and serum stability of polyplexes by PDMAEMA-polysulfobetaine diblock copolymers

Abstract Polyethylene glycol or phosphorylcholine is often introduced into polycationic non-viral vectors to inhibit the non-specific protein adsorption. However the ability of vectors to condense DNA and the cellular internalization of complexes are unavoidably compromised. In this work, a polysulf...

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Veröffentlicht in:	Biomaterials 2011-01, Vol.32 (2), p.628-638
Hauptverfasser:	Dai, Fengying, Liu, Wenguang
Format:	Artikel
Sprache:	eng
Schlagworte:	2-(dimethylamino) ethyl methacrylate Advanced Basic Science Animals Betaine - analogs & derivatives Betaine - chemistry Calorimetry, Differential Scanning Cercopithecus aethiops COS Cells Dentistry Gene delivery Genetic Vectors - chemistry Methacrylates - chemistry Nylons - chemistry Polymers - chemistry Serum stability Sulfobetaine Transfection - methods
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