Antimicrobial peptides on calcium phosphate-coated titanium for the prevention of implant-associated infections

Abstract Prevention of implant-associated infections has been one of the main challenges in orthopaedic surgery. This challenge is further complicated by the concern over the development of antibiotic resistance as a result of using traditional antibiotics for infection prophylaxis. The objective of...

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Veröffentlicht in:	Biomaterials 2010-12, Vol.31 (36), p.9519-9526
Hauptverfasser:	Kazemzadeh-Narbat, Mehdi, Kindrachuk, Jason, Duan, Ke, Jenssen, Håvard, Hancock, Robert E.W, Wang, Rizhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Antimicrobial Cationic Peptides - pharmacology Antimicrobial Cationic Peptides - therapeutic use Antimicrobial peptide Calcium phosphate coating Calcium Phosphates - pharmacology Calcium Phosphates - therapeutic use Cell Death Cell Line Coated Materials, Biocompatible - pharmacology Coated Materials, Biocompatible - therapeutic use Dentistry Electrolytic deposition Humans Immobilized Proteins - metabolism Infection Microbial Sensitivity Tests Microscopy, Electron, Scanning Orthopaedic implants Osteoblasts - cytology Osteoblasts - drug effects Prostheses and Implants - adverse effects Prosthesis-Related Infections - drug therapy Prosthesis-Related Infections - prevention & control Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Staphylococcus aureus Staphylococcus aureus - drug effects Titanium Titanium - pharmacology Titanium - therapeutic use X-Ray Diffraction
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