Discovery of a steroid 11α-hydroxylase from Rhizopus oryzae and its biotechnological application

To overcome the chemically laborious stereo- and regioselective hydroxylation steps in the pharmaceutical production of corticosteroids and progestogens, certain fungal species, e.g. Rhizopus spp. and Aspergillus spp., are employed to perform the 11α-hydroxylation of the steroid skeleton, thereby si...

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Veröffentlicht in:	Journal of biotechnology 2010-11, Vol.150 (3), p.428-437
Hauptverfasser:	Petrič, Š., Hakki, T., Bernhardt, R., Žigon, D., Črešnar, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	11α-Steroid hydroxylation Amino Acid Sequence Aspergillus Biological and medical sciences Biotechnology Biotechnology - methods Cluster Analysis Corticosteroids Cytochromes P450 Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Heterologus expression Hydroxylation Molecular Sequence Data Phylogeny Progesterone - metabolism Progesterone - pharmacology Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Rhizopus Rhizopus - enzymology Rhizopus - genetics Rhizopus oryzae Schizosaccharomyces Schizosaccharomyces pombe Sequence Alignment Steroid Hydroxylases - chemistry Steroid Hydroxylases - genetics Steroid Hydroxylases - metabolism
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