Relative Shift in Activity from Medial to Lateral Frontal Cortex During Internally Versus Externally Guided Word Generation
Goldberg (1985) hypothesized that as language output changes from internally to externally guided production, activity shifts from supplementary motor area (SMA) to lateral premotor areas, including Broca's area. To test this hypothesis, 15 right-handed native English speakers performed three w...
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| Veröffentlicht in: | Journal of cognitive neuroscience 2001-02, Vol.13 (2), p.272-283 |
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| container_title | Journal of cognitive neuroscience |
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| creator | Crosson, Bruce Sadek, Joseph R. Maron, Leeza Gökçay, Didem Mohr, Cecile M. Auerbach, Edward J. Freeman, Alan J. Leonard, Christiana M. Briggs, Richard W. |
| description | Goldberg (1985) hypothesized that as language output changes from internally to externally guided production, activity shifts from supplementary motor area (SMA) to lateral premotor areas, including Broca's area. To test this hypothesis, 15 right-handed native English speakers performed three word generation tasks varying in the amount of internal guidance and a repetition task during functional magnetic resonance imaging (fMRI). Volumes of significant activity for each task versus a resting state were derived using voxel-by-voxel repeated-measures
tests (
< .001) across subjects. Changes in the size of activity volumes for left medial frontal regions (SMA and pre-SMA/BA 32) versus left lateral frontal regions (Broca's area, inferior frontal sulcus) were assessed as internal guidance of word generation decreased and external guidance increased. Comparing SMA to Broca's area, Goldberg's hypothesis was not verified. However, pre-SMA/BA 32 activity volumes decreased significantly and inferior frontal sulcus activity volumes increased significantly as word generation tasks moved from internally to externally guided. |
| doi_str_mv | 10.1162/089892901564225 |
| format | Article |
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tests (
< .001) across subjects. Changes in the size of activity volumes for left medial frontal regions (SMA and pre-SMA/BA 32) versus left lateral frontal regions (Broca's area, inferior frontal sulcus) were assessed as internal guidance of word generation decreased and external guidance increased. Comparing SMA to Broca's area, Goldberg's hypothesis was not verified. However, pre-SMA/BA 32 activity volumes decreased significantly and inferior frontal sulcus activity volumes increased significantly as word generation tasks moved from internally to externally guided.</description><identifier>ISSN: 0898-929X</identifier><identifier>EISSN: 1530-8898</identifier><identifier>DOI: 10.1162/089892901564225</identifier><identifier>PMID: 11244551</identifier><identifier>CODEN: JCONEO</identifier><language>eng</language><publisher>One Rogers Street, Cambridge, MA 02142-1209, USA: MIT Press</publisher><subject>Adult ; Brain ; Cerebral cortex ; Female ; Frontal Lobe - physiology ; Humans ; Language ; Localization of functions ; Magnetic Resonance Imaging ; Male ; Motor Cortex - physiology ; Neurolinguistics ; Neurology ; Speech - physiology ; Speech processing systems</subject><ispartof>Journal of cognitive neuroscience, 2001-02, Vol.13 (2), p.272-283</ispartof><rights>COPYRIGHT 2001 MIT Press Journals</rights><rights>Copyright MIT Press Journals Feb 15, 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c646t-78492c634769e80cc1dcd07363bdf976e0f0c18c73b296d876b5e6dbac20df853</citedby><cites>FETCH-LOGICAL-c646t-78492c634769e80cc1dcd07363bdf976e0f0c18c73b296d876b5e6dbac20df853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://direct.mit.edu/jocn/article/doi/10.1162/089892901564225$$EHTML$$P50$$Gmit$$H</linktohtml><link.rule.ids>315,781,785,27928,27929,54013,54014</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11244551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crosson, Bruce</creatorcontrib><creatorcontrib>Sadek, Joseph R.</creatorcontrib><creatorcontrib>Maron, Leeza</creatorcontrib><creatorcontrib>Gökçay, Didem</creatorcontrib><creatorcontrib>Mohr, Cecile M.</creatorcontrib><creatorcontrib>Auerbach, Edward J.</creatorcontrib><creatorcontrib>Freeman, Alan J.</creatorcontrib><creatorcontrib>Leonard, Christiana M.</creatorcontrib><creatorcontrib>Briggs, Richard W.</creatorcontrib><title>Relative Shift in Activity from Medial to Lateral Frontal Cortex During Internally Versus Externally Guided Word Generation</title><title>Journal of cognitive neuroscience</title><addtitle>J Cogn Neurosci</addtitle><description>Goldberg (1985) hypothesized that as language output changes from internally to externally guided production, activity shifts from supplementary motor area (SMA) to lateral premotor areas, including Broca's area. To test this hypothesis, 15 right-handed native English speakers performed three word generation tasks varying in the amount of internal guidance and a repetition task during functional magnetic resonance imaging (fMRI). Volumes of significant activity for each task versus a resting state were derived using voxel-by-voxel repeated-measures
tests (
< .001) across subjects. Changes in the size of activity volumes for left medial frontal regions (SMA and pre-SMA/BA 32) versus left lateral frontal regions (Broca's area, inferior frontal sulcus) were assessed as internal guidance of word generation decreased and external guidance increased. Comparing SMA to Broca's area, Goldberg's hypothesis was not verified. However, pre-SMA/BA 32 activity volumes decreased significantly and inferior frontal sulcus activity volumes increased significantly as word generation tasks moved from internally to externally guided.</description><subject>Adult</subject><subject>Brain</subject><subject>Cerebral cortex</subject><subject>Female</subject><subject>Frontal Lobe - physiology</subject><subject>Humans</subject><subject>Language</subject><subject>Localization of functions</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Motor Cortex - physiology</subject><subject>Neurolinguistics</subject><subject>Neurology</subject><subject>Speech - physiology</subject><subject>Speech processing systems</subject><issn>0898-929X</issn><issn>1530-8898</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1vEzEQhi0EoqFw5oYsDlxgqT_WXu8xCm2oFITE983atb3B0a6d2t6qaf88DoloVQVVPow988zrmdEA8BKj9xhzcoJELWpSI8x4SQh7BCaYUVSI7H4MJttokcO_jsCzGFcIIZK5p-AIY1KWjOEJuPli-ibZSwO__rZdgtbBqcpvmzawC36An4y2TQ-Th4smmZCvZ8G7lO3Mh2Su4IcxWLeE5y5HXdP3G_jDhDhGeHr1zzMfrTYa_vRBw7lxWSZZ756DJ13TR_Nib4_B97PTb7OPxeLz_Hw2XRSKlzwVlShrojgtK14bgZTCWmlUUU5b3dUVN6hDCgtV0ZbUXIuKt8xw3TaKIN0JRo_Bm53uOviL0cQkBxuV6fvGGT9GKVieWVmiB8FcAKsxelgRC8xLhkQGX98DV37cDiVKQijiFavpLbRseiOt63wKjdoqymnFeIUIJxl6dwBa_h1m753pbHbfxYsDeD7aDFYd4k92vAo-xmA6uQ52aMJGYiS3qybvrVrOeLVvbWwHo2_5_W5lYLYDBnun7ZVX7hJTSyRFBHMqSTY5KevLa7s-8M3bAyr_K-oPteDs8w</recordid><startdate>20010215</startdate><enddate>20010215</enddate><creator>Crosson, Bruce</creator><creator>Sadek, Joseph R.</creator><creator>Maron, Leeza</creator><creator>Gökçay, Didem</creator><creator>Mohr, Cecile M.</creator><creator>Auerbach, Edward J.</creator><creator>Freeman, Alan J.</creator><creator>Leonard, Christiana M.</creator><creator>Briggs, Richard W.</creator><general>MIT Press</general><general>MIT Press Journals</general><general>MIT Press Journals, The</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>7T9</scope></search><sort><creationdate>20010215</creationdate><title>Relative Shift in Activity from Medial to Lateral Frontal Cortex During Internally Versus Externally Guided Word Generation</title><author>Crosson, Bruce ; 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tests (
< .001) across subjects. Changes in the size of activity volumes for left medial frontal regions (SMA and pre-SMA/BA 32) versus left lateral frontal regions (Broca's area, inferior frontal sulcus) were assessed as internal guidance of word generation decreased and external guidance increased. Comparing SMA to Broca's area, Goldberg's hypothesis was not verified. However, pre-SMA/BA 32 activity volumes decreased significantly and inferior frontal sulcus activity volumes increased significantly as word generation tasks moved from internally to externally guided.</abstract><cop>One Rogers Street, Cambridge, MA 02142-1209, USA</cop><pub>MIT Press</pub><pmid>11244551</pmid><doi>10.1162/089892901564225</doi><tpages>12</tpages></addata></record> |
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| subjects | Adult Brain Cerebral cortex Female Frontal Lobe - physiology Humans Language Localization of functions Magnetic Resonance Imaging Male Motor Cortex - physiology Neurolinguistics Neurology Speech - physiology Speech processing systems |
| title | Relative Shift in Activity from Medial to Lateral Frontal Cortex During Internally Versus Externally Guided Word Generation |
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