Lead generation and examples opinion regarding how to follow up hits

In fragment-based drug discovery (FBDD), not only identifying the starting fragment hit to be developed but also generating a drug lead from that starting fragment hit is important. Converting fragment hits to leads is generally similar to a high-throughput screening (HTS) hits-to-leads approach in...

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Veröffentlicht in:	Methods in enzymology 2011, Vol.493, p.383-419
Hauptverfasser:	Orita, Masaya, Ohno, Kazuki, Warizaya, Masaichi, Amano, Yasushi, Niimi, Tatsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Crystallography, X-Ray Drug Design Drug Discovery - methods Drug Evaluation, Preclinical - methods Hydrogen Bonding Ligands Proteins - metabolism
Online-Zugang:	Volltext
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