Noncovalent Pegylation by Dansyl-Poly(ethylene Glycol)s as a New Means Against Aggregation of Salmon Calcitonin

During all stages of protein drug development, aggregation is one of the most often encountered problems. Covalent conjugation of poly(ethylene glycol) (PEG), also called PEGylation, to proteins has been shown to reduce aggregation of proteins. In this paper, new excipients based on PEG are presente...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 2011-05, Vol.100 (5), p.1648-1662
Hauptverfasser:	Mueller, Claudia, Capelle, Martinus A.H., Arvinte, Tudor, Seyrek, Emek, Borchard, Gerrit
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcitonin - chemistry Drug Stability fluorescence spectroscopy General pharmacology Medical sciences noncovalent PEGylation Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols - chemistry protein aggregation protein formulaiton protein formulation Protein Stability Salmon salmon calcitonin Salmonidae Spectrometry, Fluorescence stability
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!