Peripheral Arterial Disease and Progression of Coronary Atherosclerosis
Objectives The purpose of this analysis was to characterize the progression of coronary atherosclerosis in patients with concomitant peripheral arterial disease (PAD). Background Peripheral arterial disease is associated with adverse cardiovascular outcomes. The impact of concomitant PAD on coronary...
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| creator | Hussein, Ayman A., MD Uno, Kiyoko, MD Wolski, Kathy, MPH Kapadia, Samir, MD Schoenhagen, Paul, MD Tuzcu, E. Murat, MD Nissen, Steven E., MD Nicholls, Stephen J., MBBS, PhD |
| description | Objectives The purpose of this analysis was to characterize the progression of coronary atherosclerosis in patients with concomitant peripheral arterial disease (PAD). Background Peripheral arterial disease is associated with adverse cardiovascular outcomes. The impact of concomitant PAD on coronary atherosclerosis progression in patients with coronary artery disease has not been well established. Methods The burden and progression of coronary atherosclerosis was investigated in 3,479 patients with coronary artery disease with (n = 216) and without (n = 3,263) concomitant PAD who participated in 7 clinical trials that employed serial intravascular ultrasound imaging. Results Patients with PAD had a greater percent atheroma volume (40.4 ± 9.2% vs. 38.5 ± 9.1%, p = 0.002) and percentage of images containing calcium (35.1 ± 26.2% vs. 29.6 ± 24.2%, p = 0.002), in association with smaller lumen volume (275.7 ± 101.6 mm3 vs. 301.4 ± 110.3 mm3 , p < 0.001) and vessel wall volume (467.7 ± 166.8 mm3 vs. 492.9 ± 169.8 mm3 , p = 0.01). On serial evaluation, patients with PAD demonstrated greater progression of percent atheroma volume (+0.58 ± 0.38 vs. +0.23 ± 0.3%, p = 0.009) and total atheroma volume (−0.17 ± 2.69 mm3 vs. −2.05 ± 2.15 mm3 , p = 0.03) and experienced more cardiovascular events (26.3% vs. 19.8%, p = 0.03). In patients with PAD and without PAD, respectively, achieving levels of low-density lipoprotein cholesterol |
| doi_str_mv | 10.1016/j.jacc.2010.10.034 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_855203019</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0735109710049739</els_id><sourcerecordid>3389192911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c578t-a18fdabaa0f152d3b04bfaacd7bd36737e7def789c87e84af7f1c702dc9848e43</originalsourceid><addsrcrecordid>eNp9kl2L1DAUhoMo7uzqH_BCCiJedTxpmiYBEYZxXYUFF9TrkCYnmtppxqQj7L83dUYX9sKbfBye93y8HEKeUVhToN3rYT0Ya9cN_AmsgbUPyIpyLmvGlXhIViAYrykocUbOcx4AoJNUPSZnDWWCdkytyNUNprD_jsmM1SbN5VMe70JGk7Eyk6tuUvyWMOcQpyr6ahtTnEy6rTZzEcVsx-UM-Ql55M2Y8enpviBf319-2X6orz9dfdxurmvLhZxrQ6V3pjcGPOWNYz20vTfGOtE71gkmUDj0QiorBcrWeOGpFdA4q2QrsWUX5NUx7z7FnwfMs96FbHEczYTxkLXkvAEGVBXyxT1yiIc0leY05a1SqqXQFao5UraMkRN6vU9hVwbUFPTish704rJeXF5ixeUien5Kfeh36P5J_tpagJcnwGRrRp_MZEO-45jqqBCscG-OHBbLfgVMOtuAk0UXEtpZuxj-38fbe3I7himUij_wFvPdvDo3GvTnZR-WdaAArRKlz9_Szq-s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1549994106</pqid></control><display><type>article</type><title>Peripheral Arterial Disease and Progression of Coronary Atherosclerosis</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Hussein, Ayman A., MD ; Uno, Kiyoko, MD ; Wolski, Kathy, MPH ; Kapadia, Samir, MD ; Schoenhagen, Paul, MD ; Tuzcu, E. Murat, MD ; Nissen, Steven E., MD ; Nicholls, Stephen J., MBBS, PhD</creator><creatorcontrib>Hussein, Ayman A., MD ; Uno, Kiyoko, MD ; Wolski, Kathy, MPH ; Kapadia, Samir, MD ; Schoenhagen, Paul, MD ; Tuzcu, E. Murat, MD ; Nissen, Steven E., MD ; Nicholls, Stephen J., MBBS, PhD</creatorcontrib><description>Objectives The purpose of this analysis was to characterize the progression of coronary atherosclerosis in patients with concomitant peripheral arterial disease (PAD). Background Peripheral arterial disease is associated with adverse cardiovascular outcomes. The impact of concomitant PAD on coronary atherosclerosis progression in patients with coronary artery disease has not been well established. Methods The burden and progression of coronary atherosclerosis was investigated in 3,479 patients with coronary artery disease with (n = 216) and without (n = 3,263) concomitant PAD who participated in 7 clinical trials that employed serial intravascular ultrasound imaging. Results Patients with PAD had a greater percent atheroma volume (40.4 ± 9.2% vs. 38.5 ± 9.1%, p = 0.002) and percentage of images containing calcium (35.1 ± 26.2% vs. 29.6 ± 24.2%, p = 0.002), in association with smaller lumen volume (275.7 ± 101.6 mm3 vs. 301.4 ± 110.3 mm3 , p < 0.001) and vessel wall volume (467.7 ± 166.8 mm3 vs. 492.9 ± 169.8 mm3 , p = 0.01). On serial evaluation, patients with PAD demonstrated greater progression of percent atheroma volume (+0.58 ± 0.38 vs. +0.23 ± 0.3%, p = 0.009) and total atheroma volume (−0.17 ± 2.69 mm3 vs. −2.05 ± 2.15 mm3 , p = 0.03) and experienced more cardiovascular events (26.3% vs. 19.8%, p = 0.03). In patients with PAD and without PAD, respectively, achieving levels of low-density lipoprotein cholesterol <70 mg/dl was associated with less progression of percent atheroma volume (+0.16 ± 0.27% vs. +0.76 ± 0.20%, p = 0.04; and +0.05 ± 0.14% vs. +0.29 ± 0.13%, p < 0.001) and total atheroma volume (−3.0 ± 1.9 mm3 vs. +1.0 ± 1.4 mm3 , p = 0.04; and −3.3 ± 1.1 mm3 vs. −1.6 ± 1.0 mm3 , p < 0.001). Conclusions Patients with concomitant PAD harbor more extensive and calcified coronary atherosclerosis, constrictive arterial remodeling, and greater disease progression. These changes are likely to contribute to adverse cardiovascular outcomes. The benefit for all patients achieving low levels of low-density lipoprotein cholesterol supports the need for intensive lipid lowering in patients with PAD.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2010.10.034</identifier><identifier>PMID: 21371639</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood pressure ; Body mass index ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Cholesterol ; Clinical trials ; Comorbidity ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - pathology ; Coronary heart disease ; Coronary vessels ; Diabetes ; Disease Progression ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Drug therapy ; Enzymes ; Female ; Heart ; Heart attacks ; Heart failure ; Humans ; Hypertension ; Hypolipidemic Agents - therapeutic use ; Internal Medicine ; intravascular ultrasound ; Lipoproteins ; Male ; Medical sciences ; Middle Aged ; peripheral arterial disease ; Peripheral Arterial Disease - diagnostic imaging ; Peripheral Arterial Disease - drug therapy ; Peripheral Arterial Disease - epidemiology ; Plaque, Atherosclerotic - epidemiology ; Randomized Controlled Trials as Topic ; Risk Factors ; Stroke ; Ultrasonography, Interventional</subject><ispartof>Journal of the American College of Cardiology, 2011-03, Vol.57 (10), p.1220-1225</ispartof><rights>American College of Cardiology Foundation</rights><rights>2011 American College of Cardiology Foundation</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Mar 8, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-a18fdabaa0f152d3b04bfaacd7bd36737e7def789c87e84af7f1c702dc9848e43</citedby><cites>FETCH-LOGICAL-c578t-a18fdabaa0f152d3b04bfaacd7bd36737e7def789c87e84af7f1c702dc9848e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jacc.2010.10.034$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23961773$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21371639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hussein, Ayman A., MD</creatorcontrib><creatorcontrib>Uno, Kiyoko, MD</creatorcontrib><creatorcontrib>Wolski, Kathy, MPH</creatorcontrib><creatorcontrib>Kapadia, Samir, MD</creatorcontrib><creatorcontrib>Schoenhagen, Paul, MD</creatorcontrib><creatorcontrib>Tuzcu, E. Murat, MD</creatorcontrib><creatorcontrib>Nissen, Steven E., MD</creatorcontrib><creatorcontrib>Nicholls, Stephen J., MBBS, PhD</creatorcontrib><title>Peripheral Arterial Disease and Progression of Coronary Atherosclerosis</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Objectives The purpose of this analysis was to characterize the progression of coronary atherosclerosis in patients with concomitant peripheral arterial disease (PAD). Background Peripheral arterial disease is associated with adverse cardiovascular outcomes. The impact of concomitant PAD on coronary atherosclerosis progression in patients with coronary artery disease has not been well established. Methods The burden and progression of coronary atherosclerosis was investigated in 3,479 patients with coronary artery disease with (n = 216) and without (n = 3,263) concomitant PAD who participated in 7 clinical trials that employed serial intravascular ultrasound imaging. Results Patients with PAD had a greater percent atheroma volume (40.4 ± 9.2% vs. 38.5 ± 9.1%, p = 0.002) and percentage of images containing calcium (35.1 ± 26.2% vs. 29.6 ± 24.2%, p = 0.002), in association with smaller lumen volume (275.7 ± 101.6 mm3 vs. 301.4 ± 110.3 mm3 , p < 0.001) and vessel wall volume (467.7 ± 166.8 mm3 vs. 492.9 ± 169.8 mm3 , p = 0.01). On serial evaluation, patients with PAD demonstrated greater progression of percent atheroma volume (+0.58 ± 0.38 vs. +0.23 ± 0.3%, p = 0.009) and total atheroma volume (−0.17 ± 2.69 mm3 vs. −2.05 ± 2.15 mm3 , p = 0.03) and experienced more cardiovascular events (26.3% vs. 19.8%, p = 0.03). In patients with PAD and without PAD, respectively, achieving levels of low-density lipoprotein cholesterol <70 mg/dl was associated with less progression of percent atheroma volume (+0.16 ± 0.27% vs. +0.76 ± 0.20%, p = 0.04; and +0.05 ± 0.14% vs. +0.29 ± 0.13%, p < 0.001) and total atheroma volume (−3.0 ± 1.9 mm3 vs. +1.0 ± 1.4 mm3 , p = 0.04; and −3.3 ± 1.1 mm3 vs. −1.6 ± 1.0 mm3 , p < 0.001). Conclusions Patients with concomitant PAD harbor more extensive and calcified coronary atherosclerosis, constrictive arterial remodeling, and greater disease progression. These changes are likely to contribute to adverse cardiovascular outcomes. The benefit for all patients achieving low levels of low-density lipoprotein cholesterol supports the need for intensive lipid lowering in patients with PAD.</description><subject>Atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Clinical trials</subject><subject>Comorbidity</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Disease Progression</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Drug therapy</subject><subject>Enzymes</subject><subject>Female</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypolipidemic Agents - therapeutic use</subject><subject>Internal Medicine</subject><subject>intravascular ultrasound</subject><subject>Lipoproteins</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>peripheral arterial disease</subject><subject>Peripheral Arterial Disease - diagnostic imaging</subject><subject>Peripheral Arterial Disease - drug therapy</subject><subject>Peripheral Arterial Disease - epidemiology</subject><subject>Plaque, Atherosclerotic - epidemiology</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Ultrasonography, Interventional</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl2L1DAUhoMo7uzqH_BCCiJedTxpmiYBEYZxXYUFF9TrkCYnmtppxqQj7L83dUYX9sKbfBye93y8HEKeUVhToN3rYT0Ya9cN_AmsgbUPyIpyLmvGlXhIViAYrykocUbOcx4AoJNUPSZnDWWCdkytyNUNprD_jsmM1SbN5VMe70JGk7Eyk6tuUvyWMOcQpyr6ahtTnEy6rTZzEcVsx-UM-Ql55M2Y8enpviBf319-2X6orz9dfdxurmvLhZxrQ6V3pjcGPOWNYz20vTfGOtE71gkmUDj0QiorBcrWeOGpFdA4q2QrsWUX5NUx7z7FnwfMs96FbHEczYTxkLXkvAEGVBXyxT1yiIc0leY05a1SqqXQFao5UraMkRN6vU9hVwbUFPTish704rJeXF5ixeUien5Kfeh36P5J_tpagJcnwGRrRp_MZEO-45jqqBCscG-OHBbLfgVMOtuAk0UXEtpZuxj-38fbe3I7himUij_wFvPdvDo3GvTnZR-WdaAArRKlz9_Szq-s</recordid><startdate>20110308</startdate><enddate>20110308</enddate><creator>Hussein, Ayman A., MD</creator><creator>Uno, Kiyoko, MD</creator><creator>Wolski, Kathy, MPH</creator><creator>Kapadia, Samir, MD</creator><creator>Schoenhagen, Paul, MD</creator><creator>Tuzcu, E. Murat, MD</creator><creator>Nissen, Steven E., MD</creator><creator>Nicholls, Stephen J., MBBS, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20110308</creationdate><title>Peripheral Arterial Disease and Progression of Coronary Atherosclerosis</title><author>Hussein, Ayman A., MD ; Uno, Kiyoko, MD ; Wolski, Kathy, MPH ; Kapadia, Samir, MD ; Schoenhagen, Paul, MD ; Tuzcu, E. Murat, MD ; Nissen, Steven E., MD ; Nicholls, Stephen J., MBBS, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c578t-a18fdabaa0f152d3b04bfaacd7bd36737e7def789c87e84af7f1c702dc9848e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Atherosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Clinical trials</topic><topic>Comorbidity</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary heart disease</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Disease Progression</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Drug therapy</topic><topic>Enzymes</topic><topic>Female</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypolipidemic Agents - therapeutic use</topic><topic>Internal Medicine</topic><topic>intravascular ultrasound</topic><topic>Lipoproteins</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>peripheral arterial disease</topic><topic>Peripheral Arterial Disease - diagnostic imaging</topic><topic>Peripheral Arterial Disease - drug therapy</topic><topic>Peripheral Arterial Disease - epidemiology</topic><topic>Plaque, Atherosclerotic - epidemiology</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Ultrasonography, Interventional</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hussein, Ayman A., MD</creatorcontrib><creatorcontrib>Uno, Kiyoko, MD</creatorcontrib><creatorcontrib>Wolski, Kathy, MPH</creatorcontrib><creatorcontrib>Kapadia, Samir, MD</creatorcontrib><creatorcontrib>Schoenhagen, Paul, MD</creatorcontrib><creatorcontrib>Tuzcu, E. Murat, MD</creatorcontrib><creatorcontrib>Nissen, Steven E., MD</creatorcontrib><creatorcontrib>Nicholls, Stephen J., MBBS, PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hussein, Ayman A., MD</au><au>Uno, Kiyoko, MD</au><au>Wolski, Kathy, MPH</au><au>Kapadia, Samir, MD</au><au>Schoenhagen, Paul, MD</au><au>Tuzcu, E. Murat, MD</au><au>Nissen, Steven E., MD</au><au>Nicholls, Stephen J., MBBS, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral Arterial Disease and Progression of Coronary Atherosclerosis</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2011-03-08</date><risdate>2011</risdate><volume>57</volume><issue>10</issue><spage>1220</spage><epage>1225</epage><pages>1220-1225</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>Objectives The purpose of this analysis was to characterize the progression of coronary atherosclerosis in patients with concomitant peripheral arterial disease (PAD). Background Peripheral arterial disease is associated with adverse cardiovascular outcomes. The impact of concomitant PAD on coronary atherosclerosis progression in patients with coronary artery disease has not been well established. Methods The burden and progression of coronary atherosclerosis was investigated in 3,479 patients with coronary artery disease with (n = 216) and without (n = 3,263) concomitant PAD who participated in 7 clinical trials that employed serial intravascular ultrasound imaging. Results Patients with PAD had a greater percent atheroma volume (40.4 ± 9.2% vs. 38.5 ± 9.1%, p = 0.002) and percentage of images containing calcium (35.1 ± 26.2% vs. 29.6 ± 24.2%, p = 0.002), in association with smaller lumen volume (275.7 ± 101.6 mm3 vs. 301.4 ± 110.3 mm3 , p < 0.001) and vessel wall volume (467.7 ± 166.8 mm3 vs. 492.9 ± 169.8 mm3 , p = 0.01). On serial evaluation, patients with PAD demonstrated greater progression of percent atheroma volume (+0.58 ± 0.38 vs. +0.23 ± 0.3%, p = 0.009) and total atheroma volume (−0.17 ± 2.69 mm3 vs. −2.05 ± 2.15 mm3 , p = 0.03) and experienced more cardiovascular events (26.3% vs. 19.8%, p = 0.03). In patients with PAD and without PAD, respectively, achieving levels of low-density lipoprotein cholesterol <70 mg/dl was associated with less progression of percent atheroma volume (+0.16 ± 0.27% vs. +0.76 ± 0.20%, p = 0.04; and +0.05 ± 0.14% vs. +0.29 ± 0.13%, p < 0.001) and total atheroma volume (−3.0 ± 1.9 mm3 vs. +1.0 ± 1.4 mm3 , p = 0.04; and −3.3 ± 1.1 mm3 vs. −1.6 ± 1.0 mm3 , p < 0.001). Conclusions Patients with concomitant PAD harbor more extensive and calcified coronary atherosclerosis, constrictive arterial remodeling, and greater disease progression. These changes are likely to contribute to adverse cardiovascular outcomes. The benefit for all patients achieving low levels of low-density lipoprotein cholesterol supports the need for intensive lipid lowering in patients with PAD.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21371639</pmid><doi>10.1016/j.jacc.2010.10.034</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood pressure Body mass index Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Cholesterol Clinical trials Comorbidity Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - epidemiology Coronary Artery Disease - pathology Coronary heart disease Coronary vessels Diabetes Disease Progression Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Drug therapy Enzymes Female Heart Heart attacks Heart failure Humans Hypertension Hypolipidemic Agents - therapeutic use Internal Medicine intravascular ultrasound Lipoproteins Male Medical sciences Middle Aged peripheral arterial disease Peripheral Arterial Disease - diagnostic imaging Peripheral Arterial Disease - drug therapy Peripheral Arterial Disease - epidemiology Plaque, Atherosclerotic - epidemiology Randomized Controlled Trials as Topic Risk Factors Stroke Ultrasonography, Interventional |
| title | Peripheral Arterial Disease and Progression of Coronary Atherosclerosis |
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