MPEG-hexPLA Micelles as Novel Carriers for Hypericin, a Fluorescent Marker for Use in Cancer Diagnostics
Ovarian cancer is the most common gynecological cancer diagnosed in Western countries. Detection of micrometastases at an early stage of the disease could lead to a cure rate of 90% by limiting the spread of the disease outside the ovaries. In this article, hypericin (Hy), a hydrophobic photosensiti...
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| Veröffentlicht in: | Photochemistry and photobiology 2011-03, Vol.87 (2), p.399-407 |
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| creator | Mondon, Karine Zeisser-Labouèbe, Magali Gurny, Robert Möller, Michael |
| description | Ovarian cancer is the most common gynecological cancer diagnosed in Western countries. Detection of micrometastases at an early stage of the disease could lead to a cure rate of 90% by limiting the spread of the disease outside the ovaries. In this article, hypericin (Hy), a hydrophobic photosensitizer used for the photodynamic diagnosis (PD) of ovarian cancer, was efficiently incorporated into a core of micelles made from methoxy‐poly(ethylene glycol) and hexyl‐substituted poly(lactides) copolymers. The fate of these micelles following intravenous injection was studied in vivo in two ovarian tumor‐bearing animal models. In the chick embryo chorioallantoic membrane model, 17 times more Hy accumulated in tumor nodules when Hy was delivered with micelles than when Hy was delivered as an ethanol solution. Studies of the biodistribution of Hy in Fisher rats revealed escape of these nanosized micelles ( |
| doi_str_mv | 10.1111/j.1751-1097.2010.00879.x |
| format | Article |
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Detection of micrometastases at an early stage of the disease could lead to a cure rate of 90% by limiting the spread of the disease outside the ovaries. In this article, hypericin (Hy), a hydrophobic photosensitizer used for the photodynamic diagnosis (PD) of ovarian cancer, was efficiently incorporated into a core of micelles made from methoxy‐poly(ethylene glycol) and hexyl‐substituted poly(lactides) copolymers. The fate of these micelles following intravenous injection was studied in vivo in two ovarian tumor‐bearing animal models. In the chick embryo chorioallantoic membrane model, 17 times more Hy accumulated in tumor nodules when Hy was delivered with micelles than when Hy was delivered as an ethanol solution. Studies of the biodistribution of Hy in Fisher rats revealed escape of these nanosized micelles (<32 nm) from the mononuclear phagocyte system. Hy‐loaded micelles showed maximal accumulation in tumors and demonstrated the best tumor/muscle contrast visible 3 h after injection in the rat model. The rapid and highly selective accumulation of Hy in tumors that we demonstrated in this study suggests that these micelle formulations could be used for the PD of ovarian cancer in the future.</description><identifier>ISSN: 0031-8655</identifier><identifier>EISSN: 1751-1097</identifier><identifier>DOI: 10.1111/j.1751-1097.2010.00879.x</identifier><identifier>PMID: 21166812</identifier><identifier>CODEN: PHCBAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animal models ; Animals ; Cancer ; Cancer therapies ; Copolymers ; Ethanol ; Fatalities ; Female ; Fluorescent Dyes ; Head & neck cancer ; Injection ; Micelles ; Molecular weight ; Neoplasms - diagnosis ; Ovarian cancer ; Ovarian Neoplasms - diagnosis ; Perylene - analogs & derivatives ; Perylene - chemistry ; Polyesters - chemistry ; Polyethylene Glycols - chemistry ; Rats ; Tumors</subject><ispartof>Photochemistry and photobiology, 2011-03, Vol.87 (2), p.399-407</ispartof><rights>2011 The Authors. Photochemistry and Photobiology © 2011 The American Society of Photobiology</rights><rights>2011 The Authors. Photochemistry and Photobiology © 2011 The American Society of Photobiology.</rights><rights>Copyright American Society for Photobiology Mar/Apr 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4329-4af63a5b1abadb1b31e83d3dc5f5597aa19f889902effe7bf93f31da53b8d133</citedby><cites>FETCH-LOGICAL-c4329-4af63a5b1abadb1b31e83d3dc5f5597aa19f889902effe7bf93f31da53b8d133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1751-1097.2010.00879.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1751-1097.2010.00879.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21166812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mondon, Karine</creatorcontrib><creatorcontrib>Zeisser-Labouèbe, Magali</creatorcontrib><creatorcontrib>Gurny, Robert</creatorcontrib><creatorcontrib>Möller, Michael</creatorcontrib><title>MPEG-hexPLA Micelles as Novel Carriers for Hypericin, a Fluorescent Marker for Use in Cancer Diagnostics</title><title>Photochemistry and photobiology</title><addtitle>Photochem Photobiol</addtitle><description>Ovarian cancer is the most common gynecological cancer diagnosed in Western countries. Detection of micrometastases at an early stage of the disease could lead to a cure rate of 90% by limiting the spread of the disease outside the ovaries. In this article, hypericin (Hy), a hydrophobic photosensitizer used for the photodynamic diagnosis (PD) of ovarian cancer, was efficiently incorporated into a core of micelles made from methoxy‐poly(ethylene glycol) and hexyl‐substituted poly(lactides) copolymers. The fate of these micelles following intravenous injection was studied in vivo in two ovarian tumor‐bearing animal models. In the chick embryo chorioallantoic membrane model, 17 times more Hy accumulated in tumor nodules when Hy was delivered with micelles than when Hy was delivered as an ethanol solution. Studies of the biodistribution of Hy in Fisher rats revealed escape of these nanosized micelles (<32 nm) from the mononuclear phagocyte system. Hy‐loaded micelles showed maximal accumulation in tumors and demonstrated the best tumor/muscle contrast visible 3 h after injection in the rat model. The rapid and highly selective accumulation of Hy in tumors that we demonstrated in this study suggests that these micelle formulations could be used for the PD of ovarian cancer in the future.</description><subject>Animal models</subject><subject>Animals</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Copolymers</subject><subject>Ethanol</subject><subject>Fatalities</subject><subject>Female</subject><subject>Fluorescent Dyes</subject><subject>Head & neck cancer</subject><subject>Injection</subject><subject>Micelles</subject><subject>Molecular weight</subject><subject>Neoplasms - diagnosis</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - diagnosis</subject><subject>Perylene - analogs & derivatives</subject><subject>Perylene - chemistry</subject><subject>Polyesters - chemistry</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Rats</subject><subject>Tumors</subject><issn>0031-8655</issn><issn>1751-1097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFv0zAUxi0EYmXsX0AWFy6k-MV1YktcprK2m9rSaUMcLSd5Zi5p0tkNtP89zjp64IR98NPz7_tkv48QCmwIcX1aDyEXkABT-TBlscuYzNVw_4IMThcvyYAxDonMhDgjb0JYMwYjlcNrcpYCZJmEdEAeFqurafKA-9X8ki5ciXWNgZpAl-0vrOnYeO_QB2pbT2eHLXpXuuYjNXRSd63HUGKzowvjf6J_Yr4FpK6JuqaMnS_O_GjasHNleEteWVMHvHg-z8n95Op-PEvmX6fX48t5Uo54qpKRsRk3ogBTmKqAggNKXvGqFFYIlRsDykqpFEvRWswLq7jlUBnBC1kB5-fkw9F269vHDsNOb1zof2UabLugpRApizuN5Pt_yHXb-Sa-TcuMScYEkxGSR6j0bQgerd56tzH-oIHpPgq91v3EdT9x3Uehn6LQ-yh99-zfFRusTsK_s4_A5yPw29V4-G9jvZqtYhHlyVHuwg73J3mMQmc5z4X-vpxquFnezm9nE33H_wA3W6W2</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Mondon, Karine</creator><creator>Zeisser-Labouèbe, Magali</creator><creator>Gurny, Robert</creator><creator>Möller, Michael</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>7TM</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201103</creationdate><title>MPEG-hexPLA Micelles as Novel Carriers for Hypericin, a Fluorescent Marker for Use in Cancer Diagnostics</title><author>Mondon, Karine ; 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Hy‐loaded micelles showed maximal accumulation in tumors and demonstrated the best tumor/muscle contrast visible 3 h after injection in the rat model. The rapid and highly selective accumulation of Hy in tumors that we demonstrated in this study suggests that these micelle formulations could be used for the PD of ovarian cancer in the future.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21166812</pmid><doi>10.1111/j.1751-1097.2010.00879.x</doi><tpages>9</tpages></addata></record> |
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| subjects | Animal models Animals Cancer Cancer therapies Copolymers Ethanol Fatalities Female Fluorescent Dyes Head & neck cancer Injection Micelles Molecular weight Neoplasms - diagnosis Ovarian cancer Ovarian Neoplasms - diagnosis Perylene - analogs & derivatives Perylene - chemistry Polyesters - chemistry Polyethylene Glycols - chemistry Rats Tumors |
| title | MPEG-hexPLA Micelles as Novel Carriers for Hypericin, a Fluorescent Marker for Use in Cancer Diagnostics |
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