Identification, structural properties and chelating capacity of miltipolone as a broad-spectrum inhibitor to cancer cells

Miltipolone ( 1) was discovered as a good and broad-spectrum inhibitor against the growth of cancer cells from “Danshen” based on the activity-driven screening of TCMs. The structural features make 1 easily tautomerize between different forms and 1 is linked and stabilized by intermolecular O–H⋯O hy...

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Veröffentlicht in:	European journal of medicinal chemistry 2011-04, Vol.46 (4), p.1117-1121
Hauptverfasser:	Wang, Jing, Chen, Shaopeng, Cheng, Hao, Yang, Fangyi, Wan, Junting, Bo, Jian, Liu, Yingxue, Yang, Junyun, Liu, Jinsong, Zhou, Guo-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - analysis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects Crystallography, X-Ray Danshen Diterpenes - analysis Diterpenes - chemistry Diterpenes - pharmacology General pharmacology Humans Inhibitory activity Iron - chemistry Iron Chelating Agents - analysis Iron Chelating Agents - chemistry Iron Chelating Agents - pharmacology Isomerism Medical sciences Metal ion chelator Miltipolone Models, Molecular Molecular Conformation Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Tautomeric effect Tropolone - analogs & derivatives Tropolone - analysis Tropolone - chemistry Tropolone - pharmacology Water - chemistry
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