Differential contribution of mitochondria, NADPH oxidases, and glycolysis to region-specific oxidant stress in the anoxic-reoxygenated embryonic heart

The ability of the developing myocardium to tolerate oxidative stress during early gestation is an important issue with regard to possible detrimental consequences for the fetus. In the embryonic heart, antioxidant defences are low, whereas glycolytic flux is high. The pro- and antioxidant mechanism...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2011-03, Vol.300 (3), p.H820-H835
Hauptverfasser:	Raddatz, Eric, Thomas, Anne-Catherine, Sarre, Alexandre, Benathan, Messod
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Chick Embryo Electron Transport Complex I - antagonists & inhibitors Electron Transport Complex I - metabolism Electron Transport Complex III - antagonists & inhibitors Electron Transport Complex III - metabolism Embryos Glucose Glycogen - metabolism Glycolysis - drug effects Glycolysis - physiology Heart Heart - drug effects Heart - physiopathology Hypoxia - drug therapy Hypoxia - metabolism Hypoxia - physiopathology Iodoacetates - pharmacology Lactates - metabolism Metabolism Methacrylates - pharmacology Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Mitochondria, Heart - physiology Myocardium - metabolism NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - metabolism NADPH Oxidases - physiology NG-Nitroarginine Methyl Ester - pharmacology Ornithine - analogs & derivatives Ornithine - pharmacology Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Poultry Reactive Oxygen Species - metabolism Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - physiopathology Rotenone - pharmacology Thiazoles - pharmacology
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