Biomimetic Total Syntheses of Flinderoles B and C

A simple and efficient biomimetic synthesis of pyrrolo[1,2-a]indoles using a highly stereo- and regioselective [3 + 2] reaction cascade was developed and then further applied in the first total synthesis of flinderoles B and C, which proceeded in 17.2% yield over the longest linear sequence of 11 st...

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Veröffentlicht in:	Journal of the American Chemical Society 2011-03, Vol.133 (9), p.2864-2867
Hauptverfasser:	Dethe, Dattatraya H, Erande, Rohan D, Ranjan, Alok
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - chemical synthesis Biomimetics - economics Biomimetics - methods Indole Alkaloids - chemical synthesis Malaria - drug therapy Stereoisomerism
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