Biomimetic Total Syntheses of Flinderoles B and C

Biomimetic Total Syntheses of Flinderoles B and C

A simple and efficient biomimetic synthesis of pyrrolo[1,2-a]indoles using a highly stereo- and regioselective [3 + 2] reaction cascade was developed and then further applied in the first total synthesis of flinderoles B and C, which proceeded in 17.2% yield over the longest linear sequence of 11 st...

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Veröffentlicht in:Journal of the American Chemical Society 2011-03, Vol.133 (9), p.2864-2867
Hauptverfasser: Dethe, Dattatraya H, Erande, Rohan D, Ranjan, Alok
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Sprache:eng
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Antimalarials - chemical synthesis
Biomimetics - economics
Biomimetics - methods
Indole Alkaloids - chemical synthesis
Malaria - drug therapy
Stereoisomerism
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container_issue 9
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container_title Journal of the American Chemical Society
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creator Dethe, Dattatraya H
Erande, Rohan D
Ranjan, Alok
description A simple and efficient biomimetic synthesis of pyrrolo[1,2-a]indoles using a highly stereo- and regioselective [3 + 2] reaction cascade was developed and then further applied in the first total synthesis of flinderoles B and C, which proceeded in 17.2% yield over the longest linear sequence of 11 steps.
doi_str_mv 10.1021/ja1116974
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subjects Antimalarials - chemical synthesis
Biomimetics - economics
Biomimetics - methods
Indole Alkaloids - chemical synthesis
Malaria - drug therapy
Stereoisomerism
title Biomimetic Total Syntheses of Flinderoles B and C
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