Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents

Resistance to conventional chemotherapy is a major problem in several paediatric tumours. One explanation for this is that tumour cells are unable to engage apoptosis after cytotoxic drug-induced damage. Inhibitor of apoptosis proteins (IAPs) function by inhibiting both effector (9) and initiator (3...

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Veröffentlicht in:	Oncology reports 2011-04, Vol.25 (4), p.1177-1181
Hauptverfasser:	HOLT, Sarah V, BROOKES, Karen E, DIVE, Caroline, MAKIN, Guy W. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibiotics, Antineoplastic - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Biological and medical sciences Blotting, Western Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Bone Neoplasms - pathology Child Doxorubicin - pharmacology Drug Resistance, Neoplasm - drug effects Etoposide - pharmacology Humans Medical sciences Oligonucleotides - pharmacology Osteosarcoma - drug therapy Osteosarcoma - metabolism Osteosarcoma - pathology Rhabdomyosarcoma - drug therapy Rhabdomyosarcoma - metabolism Rhabdomyosarcoma - pathology Sarcoma, Ewing - drug therapy Sarcoma, Ewing - metabolism Sarcoma, Ewing - pathology Tumor Cells, Cultured Tumor Stem Cell Assay Tumors Vincristine - pharmacology X-Linked Inhibitor of Apoptosis Protein - antagonists & inhibitors X-Linked Inhibitor of Apoptosis Protein - genetics X-Linked Inhibitor of Apoptosis Protein - metabolism
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