Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma

Expression levels of the novel tumor suppressor gene REIC/Dkk-3 are reduced in many human cancers. We have previously showed that an adenovirus vector carrying REIC/Dkk-3 (Ad-REIC) induced apoptosis of cancer cells selectively and exerted bystander antitumor effects via ER stress. We examined possib...

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Veröffentlicht in:	Oncology reports 2011-04, Vol.25 (4), p.989-995
Hauptverfasser:	SWE SWE THAN, KATAOKA, Ken, KUMON, Hiromi, HUH, Nam-Ho, SAKAGUCHI, Masakiyo, MURATA, Hitoshi, ABARZUA, Fernando, TAKETA, Chika, GANG DU, YASHIRO, Masakazu, YANAGIHARA, Kazuyoshi, NASU, Yasutomo
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Adenocarcinoma, Scirrhous - genetics Adenocarcinoma, Scirrhous - pathology Adenocarcinoma, Scirrhous - therapy Adenoviridae - genetics Animals Apoptosis Biological and medical sciences Blotting, Western Cell Line, Tumor Female Gastroenterology. Liver. Pancreas. Abdomen Genetic Therapy Genetic Vectors - administration & dosage Humans Immunoenzyme Techniques Injections, Intraperitoneal Intercellular Signaling Peptides and Proteins - genetics Medical sciences Mice Mice, Inbred BALB C Mice, Nude Peritoneal Neoplasms - genetics Peritoneal Neoplasms - secondary Peritoneal Neoplasms - therapy Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Stomach Neoplasms - genetics Stomach Neoplasms - pathology Stomach Neoplasms - therapy Tumors
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