1-(3-Biaryloxy-2-oxopropyl)indole-5-carboxylic Acids and Related Compounds as Dual Inhibitors of Human Cytosolic Phospholipase A2α and Fatty Acid Amide Hydrolase

Cytosolic phospholipase A2α (cPLA2α) and fatty acid amide hydrolase (FAAH) are enzymes that have emerged as attractive targets for the development of analgesic and anti‐inflammatory drugs. We recently reported that 1‐[3‐(4‐octylphenoxy)‐2‐ oxopropyl]indole‐5‐carboxylic acid (5) is a dual inhibitor o...

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Veröffentlicht in:	ChemMedChem 2011-03, Vol.6 (3), p.544-549
Hauptverfasser:	Zahov, Stefan, Drews, Andreas, Hess, Mark, Schulze Elfringhoff, Alwine, Lehr, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	1-indol-1-yl-propan-2-one Amidohydrolases - antagonists & inhibitors Amidohydrolases - metabolism Analgesics Analgesics - chemical synthesis Analgesics - chemistry Analgesics - pharmacology Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Carboxylic acids Carboxylic Acids - chemical synthesis Carboxylic Acids - chemistry Carboxylic Acids - pharmacology cytosolic phospholipase A2α Drug development Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes Fatty acids Fatty-acid amide hydrolase Functional groups Group IV Phospholipases A2 - antagonists & inhibitors Group IV Phospholipases A2 - metabolism Humans Hydrolase Indoles Indoles - chemistry Inflammation Inhibitors monoacylglycerol lipase Phospholipase Phospholipase A2 Structure-Activity Relationship
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