Synthesis and Radioprotective Properties of Pulvinic Acid Derivatives

A high‐throughput screening method has highlighted the marked antioxidant activity of some pulvinic acid derivatives (PADs) towards oxidation of thymidine, under γ and UV irradiation, and Fenton‐like conditions. Here, we report the synthesis of a series of new hydrophilic PADs and the evaluation of...

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Veröffentlicht in:	ChemMedChem 2011-03, Vol.6 (3), p.561-569
Hauptverfasser:	Le Roux, Antoine, Meunier, Stéphane, Le Gall, Thierry, Denis, Jean-Marc, Bischoff, Pierre, Wagner, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - chemical synthesis 4-Butyrolactone - chemistry 4-Butyrolactone - pharmacology Antioxidants Carboxylic Acids - chemical synthesis Carboxylic Acids - chemistry Carboxylic Acids - pharmacology Cell culture Cell death Cell Line Fluorescence High-Throughput Screening Assays Humans ionizing radiation Irradiation Lactones - chemical synthesis Lactones - chemistry Lactones - pharmacology Oxidation Phenylacetates - chemical synthesis Phenylacetates - chemistry Phenylacetates - pharmacology pulvinic acids Radiation Radiation-Protective Agents - chemical synthesis Radiation-Protective Agents - chemistry Radiation-Protective Agents - pharmacology Radioprotective agents Synthesis Thymidine TK6 cells Ultraviolet radiation Ultraviolet Rays
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