Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography
A noninvasive method to determine postprandial fatty acid tissue partition may elucidate the link between excess dietary fat and type 2 diabetes. We hypothesized that the positron-emitting fatty acid analog 14(R,S)-[(18)F]fluoro-6-thia-heptadecanoic acid ((18)FTHA) administered orally during a meal...
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| Veröffentlicht in: | American journal of physiology: endocrinology and metabolism 2011-03, Vol.300 (3), p.E445-E453 |
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| creator | Labbé, Sébastien M Grenier-Larouche, Thomas Croteau, Etienne Normand-Lauzière, François Frisch, Frédérique Ouellet, René Guérin, Brigitte Turcotte, Eric E Carpentier, André C |
| description | A noninvasive method to determine postprandial fatty acid tissue partition may elucidate the link between excess dietary fat and type 2 diabetes. We hypothesized that the positron-emitting fatty acid analog 14(R,S)-[(18)F]fluoro-6-thia-heptadecanoic acid ((18)FTHA) administered orally during a meal would be incorporated into chylomicron triglycerides, allowing determination of interorgan dietary fatty acid uptake. We administered (18)FTHA orally at the beginning of a standard liquid meal ingested in nine healthy men. There was no significant (18)FTHA uptake in the portal vein and the liver during the 1st hour. Whole body PET/CT acquisition revealed early appearance of (18)FTHA in the distal thoracic duct, reaching a peak at time 240 min. (18)FTHA mean standard uptake value increased progressively in the liver, heart, quadriceps, and subcutaneous and visceral adipose tissues between time 60 and 240 min. Most circulating (18)F activity between time 0 and 360 min was recovered into chylomicron triglycerides. Using Triton WR-1339 treatment in rats that received (18)FTHA by gavage, we confirmed that >90% of this tracer reached the circulation as triglycerides. This novel noninvasive method to determine tissue dietary fatty acid distribution in humans should prove useful in the study of the mechanisms leading to lipotoxicity. |
| doi_str_mv | 10.1152/ajpendo.00579.2010 |
| format | Article |
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We hypothesized that the positron-emitting fatty acid analog 14(R,S)-[(18)F]fluoro-6-thia-heptadecanoic acid ((18)FTHA) administered orally during a meal would be incorporated into chylomicron triglycerides, allowing determination of interorgan dietary fatty acid uptake. We administered (18)FTHA orally at the beginning of a standard liquid meal ingested in nine healthy men. There was no significant (18)FTHA uptake in the portal vein and the liver during the 1st hour. Whole body PET/CT acquisition revealed early appearance of (18)FTHA in the distal thoracic duct, reaching a peak at time 240 min. (18)FTHA mean standard uptake value increased progressively in the liver, heart, quadriceps, and subcutaneous and visceral adipose tissues between time 60 and 240 min. Most circulating (18)F activity between time 0 and 360 min was recovered into chylomicron triglycerides. Using Triton WR-1339 treatment in rats that received (18)FTHA by gavage, we confirmed that >90% of this tracer reached the circulation as triglycerides. This novel noninvasive method to determine tissue dietary fatty acid distribution in humans should prove useful in the study of the mechanisms leading to lipotoxicity.</description><identifier>ISSN: 0193-1849</identifier><identifier>EISSN: 1522-1555</identifier><identifier>DOI: 10.1152/ajpendo.00579.2010</identifier><identifier>PMID: 21098737</identifier><identifier>CODEN: AJPMD9</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Adolescent ; Adult ; Animals ; Blood Glucose - metabolism ; Chylomicrons - metabolism ; Diabetes ; Diabetes Mellitus, Type 2 - metabolism ; Dietary Fats - pharmacokinetics ; Fatty acids ; Fatty Acids - pharmacokinetics ; Fatty Acids, Nonesterified - blood ; Humans ; Insulin - blood ; Insulin Resistance - physiology ; Male ; Men ; Metabolism ; Middle Aged ; Oils & fats ; Palmitates - metabolism ; Positron-Emission Tomography ; Radiopharmaceuticals - pharmacokinetics ; Rats ; Rats, Wistar ; Rodents ; Tissues ; Tomography ; Tomography, Emission-Computed ; Toxicity ; Triazoles - pharmacokinetics ; Triglycerides - blood ; Triglycerides - metabolism ; Whole-Body Counting ; Young Adult</subject><ispartof>American journal of physiology: endocrinology and metabolism, 2011-03, Vol.300 (3), p.E445-E453</ispartof><rights>Copyright American Physiological Society Mar 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-8b68d32196a4b2fac5471aae275c221d749f6cc3796b968516c9a673f21f58163</citedby><cites>FETCH-LOGICAL-c329t-8b68d32196a4b2fac5471aae275c221d749f6cc3796b968516c9a673f21f58163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21098737$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Labbé, Sébastien M</creatorcontrib><creatorcontrib>Grenier-Larouche, Thomas</creatorcontrib><creatorcontrib>Croteau, Etienne</creatorcontrib><creatorcontrib>Normand-Lauzière, François</creatorcontrib><creatorcontrib>Frisch, Frédérique</creatorcontrib><creatorcontrib>Ouellet, René</creatorcontrib><creatorcontrib>Guérin, Brigitte</creatorcontrib><creatorcontrib>Turcotte, Eric E</creatorcontrib><creatorcontrib>Carpentier, André C</creatorcontrib><title>Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography</title><title>American journal of physiology: endocrinology and metabolism</title><addtitle>Am J Physiol Endocrinol Metab</addtitle><description>A noninvasive method to determine postprandial fatty acid tissue partition may elucidate the link between excess dietary fat and type 2 diabetes. We hypothesized that the positron-emitting fatty acid analog 14(R,S)-[(18)F]fluoro-6-thia-heptadecanoic acid ((18)FTHA) administered orally during a meal would be incorporated into chylomicron triglycerides, allowing determination of interorgan dietary fatty acid uptake. We administered (18)FTHA orally at the beginning of a standard liquid meal ingested in nine healthy men. There was no significant (18)FTHA uptake in the portal vein and the liver during the 1st hour. Whole body PET/CT acquisition revealed early appearance of (18)FTHA in the distal thoracic duct, reaching a peak at time 240 min. (18)FTHA mean standard uptake value increased progressively in the liver, heart, quadriceps, and subcutaneous and visceral adipose tissues between time 60 and 240 min. Most circulating (18)F activity between time 0 and 360 min was recovered into chylomicron triglycerides. Using Triton WR-1339 treatment in rats that received (18)FTHA by gavage, we confirmed that >90% of this tracer reached the circulation as triglycerides. This novel noninvasive method to determine tissue dietary fatty acid distribution in humans should prove useful in the study of the mechanisms leading to lipotoxicity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Blood Glucose - metabolism</subject><subject>Chylomicrons - metabolism</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Dietary Fats - pharmacokinetics</subject><subject>Fatty acids</subject><subject>Fatty Acids - pharmacokinetics</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Men</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Oils & fats</subject><subject>Palmitates - metabolism</subject><subject>Positron-Emission Tomography</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Tissues</subject><subject>Tomography</subject><subject>Tomography, Emission-Computed</subject><subject>Toxicity</subject><subject>Triazoles - pharmacokinetics</subject><subject>Triglycerides - blood</subject><subject>Triglycerides - metabolism</subject><subject>Whole-Body Counting</subject><subject>Young Adult</subject><issn>0193-1849</issn><issn>1522-1555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctOAyEUhonR2Fp9AReGuHE1FZgBhqUx3pIm3eh6QhmmpXYG5LLo20tvLlzxh_Odk5PzAXCL0RRjSh7l2umhtVOEKBdTgjA6A-NcIAWmlJ6DMcKiLHBdiRG4CmGNEOK0IpdgRDASNS_5GMS5X8qhCE4r0xkFW6Oj9FvYyRi3UCrTwuSi_NbQDHCVejkEmIIZltDZYKK3A9S9CcHkEG1vl1661RYqm9xGt_krx96luM-n8jW46OQm6JvjOwFfry-fz-_FbP728fw0K1RJRCzqBavbkmDBZLUgnVS04lhKTThVhOCWV6JjSpVcsIVgNcVMCcl42RHc0RqzcgIeDnOdtz9Jh9jkVZXebOSgbQpNTSvKKsSrTN7_I9c2-SEvt4M4ybciGSIHSHkbgtdd47zp87UajJqdkeZopNkbaXZGctPdcXJa9Lr9azkpKH8BSSyKSA</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Labbé, Sébastien M</creator><creator>Grenier-Larouche, Thomas</creator><creator>Croteau, Etienne</creator><creator>Normand-Lauzière, François</creator><creator>Frisch, Frédérique</creator><creator>Ouellet, René</creator><creator>Guérin, Brigitte</creator><creator>Turcotte, Eric E</creator><creator>Carpentier, André C</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>201103</creationdate><title>Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography</title><author>Labbé, Sébastien M ; Grenier-Larouche, Thomas ; Croteau, Etienne ; Normand-Lauzière, François ; Frisch, Frédérique ; Ouellet, René ; Guérin, Brigitte ; Turcotte, Eric E ; Carpentier, André C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-8b68d32196a4b2fac5471aae275c221d749f6cc3796b968516c9a673f21f58163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Animals</topic><topic>Blood Glucose - metabolism</topic><topic>Chylomicrons - metabolism</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Dietary Fats - pharmacokinetics</topic><topic>Fatty acids</topic><topic>Fatty Acids - pharmacokinetics</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Men</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Oils & fats</topic><topic>Palmitates - metabolism</topic><topic>Positron-Emission Tomography</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Tissues</topic><topic>Tomography</topic><topic>Tomography, Emission-Computed</topic><topic>Toxicity</topic><topic>Triazoles - pharmacokinetics</topic><topic>Triglycerides - blood</topic><topic>Triglycerides - metabolism</topic><topic>Whole-Body Counting</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Labbé, Sébastien M</creatorcontrib><creatorcontrib>Grenier-Larouche, Thomas</creatorcontrib><creatorcontrib>Croteau, Etienne</creatorcontrib><creatorcontrib>Normand-Lauzière, François</creatorcontrib><creatorcontrib>Frisch, Frédérique</creatorcontrib><creatorcontrib>Ouellet, René</creatorcontrib><creatorcontrib>Guérin, Brigitte</creatorcontrib><creatorcontrib>Turcotte, Eric E</creatorcontrib><creatorcontrib>Carpentier, André C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology: endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Labbé, Sébastien M</au><au>Grenier-Larouche, Thomas</au><au>Croteau, Etienne</au><au>Normand-Lauzière, François</au><au>Frisch, Frédérique</au><au>Ouellet, René</au><au>Guérin, Brigitte</au><au>Turcotte, Eric E</au><au>Carpentier, André C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography</atitle><jtitle>American journal of physiology: endocrinology and metabolism</jtitle><addtitle>Am J Physiol Endocrinol Metab</addtitle><date>2011-03</date><risdate>2011</risdate><volume>300</volume><issue>3</issue><spage>E445</spage><epage>E453</epage><pages>E445-E453</pages><issn>0193-1849</issn><eissn>1522-1555</eissn><coden>AJPMD9</coden><abstract>A noninvasive method to determine postprandial fatty acid tissue partition may elucidate the link between excess dietary fat and type 2 diabetes. We hypothesized that the positron-emitting fatty acid analog 14(R,S)-[(18)F]fluoro-6-thia-heptadecanoic acid ((18)FTHA) administered orally during a meal would be incorporated into chylomicron triglycerides, allowing determination of interorgan dietary fatty acid uptake. We administered (18)FTHA orally at the beginning of a standard liquid meal ingested in nine healthy men. There was no significant (18)FTHA uptake in the portal vein and the liver during the 1st hour. Whole body PET/CT acquisition revealed early appearance of (18)FTHA in the distal thoracic duct, reaching a peak at time 240 min. (18)FTHA mean standard uptake value increased progressively in the liver, heart, quadriceps, and subcutaneous and visceral adipose tissues between time 60 and 240 min. Most circulating (18)F activity between time 0 and 360 min was recovered into chylomicron triglycerides. Using Triton WR-1339 treatment in rats that received (18)FTHA by gavage, we confirmed that >90% of this tracer reached the circulation as triglycerides. This novel noninvasive method to determine tissue dietary fatty acid distribution in humans should prove useful in the study of the mechanisms leading to lipotoxicity.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>21098737</pmid><doi>10.1152/ajpendo.00579.2010</doi></addata></record> |
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| subjects | Adolescent Adult Animals Blood Glucose - metabolism Chylomicrons - metabolism Diabetes Diabetes Mellitus, Type 2 - metabolism Dietary Fats - pharmacokinetics Fatty acids Fatty Acids - pharmacokinetics Fatty Acids, Nonesterified - blood Humans Insulin - blood Insulin Resistance - physiology Male Men Metabolism Middle Aged Oils & fats Palmitates - metabolism Positron-Emission Tomography Radiopharmaceuticals - pharmacokinetics Rats Rats, Wistar Rodents Tissues Tomography Tomography, Emission-Computed Toxicity Triazoles - pharmacokinetics Triglycerides - blood Triglycerides - metabolism Whole-Body Counting Young Adult |
| title | Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography |
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