Pandemic H1N1 vaccine requires the use of an adjuvant to protect against challenge in naïve ferrets
Abstract In the context of an A/H1N1 influenza pandemic situation, this study demonstrates that heterologous vaccination with an AS03-adjuvanted 2008/2009 seasonal trivalent and pandemic H5N1 monovalent split vaccine conferred partial protection in influenza-naïve ferrets after challenge with the in...
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| Veröffentlicht in: | Vaccine 2011-03, Vol.29 (11), p.2120-2126 |
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| creator | Baras, Benoît de Waal, Leon Stittelaar, Koert J Jacob, Valérie Giannini, Sandra Veldhuis Kroeze, Edwin J.B van den Brand, Judith M.A van Amerongen, Geert Simon, James H Hanon, Emmanuel Mossman, Sally P Osterhaus, Albert D.M.E |
| description | Abstract In the context of an A/H1N1 influenza pandemic situation, this study demonstrates that heterologous vaccination with an AS03-adjuvanted 2008/2009 seasonal trivalent and pandemic H5N1 monovalent split vaccine conferred partial protection in influenza-naïve ferrets after challenge with the influenza pandemic H1N1 A/The Netherlands/602/09 virus. Further, unlike saline control and non-adjuvanted vaccine, it was shown that immunization of naïve ferrets with an AS03-adjuvanted pandemic H1N1 A/California/7/09 influenza split vaccine induced increased antibody response and enhanced protection against the challenge strain, including significant reduction in viral shedding in the upper respiratory tract and reduced lung pathology post-challenge. These results show the need for vaccination with the adjuvanted vaccine to fully protect against viral replication and influenza disease in unprimed ferrets. |
| doi_str_mv | 10.1016/j.vaccine.2010.12.125 |
| format | Article |
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Further, unlike saline control and non-adjuvanted vaccine, it was shown that immunization of naïve ferrets with an AS03-adjuvanted pandemic H1N1 A/California/7/09 influenza split vaccine induced increased antibody response and enhanced protection against the challenge strain, including significant reduction in viral shedding in the upper respiratory tract and reduced lung pathology post-challenge. These results show the need for vaccination with the adjuvanted vaccine to fully protect against viral replication and influenza disease in unprimed ferrets.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2010.12.125</identifier><identifier>PMID: 21238573</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adjuvants, Immunologic - pharmacology ; Allergy and Immunology ; Animals ; Antibodies, Viral - blood ; Applied microbiology ; AS03 ; Avian flu ; Biological and medical sciences ; Ferret ; Ferrets ; Fundamental and applied biological sciences. Psychology ; H1N1 ; Histology ; Histopathology ; Immunization ; Influenza A Virus, H1N1 Subtype - immunology ; Influenza A Virus, H1N1 Subtype - physiology ; Influenza A Virus, H5N1 Subtype - immunology ; Influenza A Virus, H5N1 Subtype - physiology ; Influenza Vaccines - immunology ; Lung - pathology ; Lung - virology ; Microbiology ; Neutralization Tests ; Orthomyxoviridae Infections - immunology ; Orthomyxoviridae Infections - prevention & control ; Pandemics ; Pathology ; Respiratory tract ; Swine flu ; Vaccine ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Viral Load ; Virus Replication ; Virus Shedding</subject><ispartof>Vaccine, 2011-03, Vol.29 (11), p.2120-2126</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Mar 3, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-34514a2191a26a4e9beebe13d9f667b4000e532c08a42ea039ec4b9428d94c293</citedby><cites>FETCH-LOGICAL-c477t-34514a2191a26a4e9beebe13d9f667b4000e532c08a42ea039ec4b9428d94c293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1498110480?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23922906$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21238573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baras, Benoît</creatorcontrib><creatorcontrib>de Waal, Leon</creatorcontrib><creatorcontrib>Stittelaar, Koert J</creatorcontrib><creatorcontrib>Jacob, Valérie</creatorcontrib><creatorcontrib>Giannini, Sandra</creatorcontrib><creatorcontrib>Veldhuis Kroeze, Edwin J.B</creatorcontrib><creatorcontrib>van den Brand, Judith M.A</creatorcontrib><creatorcontrib>van Amerongen, Geert</creatorcontrib><creatorcontrib>Simon, James H</creatorcontrib><creatorcontrib>Hanon, Emmanuel</creatorcontrib><creatorcontrib>Mossman, Sally P</creatorcontrib><creatorcontrib>Osterhaus, Albert D.M.E</creatorcontrib><title>Pandemic H1N1 vaccine requires the use of an adjuvant to protect against challenge in naïve ferrets</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract In the context of an A/H1N1 influenza pandemic situation, this study demonstrates that heterologous vaccination with an AS03-adjuvanted 2008/2009 seasonal trivalent and pandemic H5N1 monovalent split vaccine conferred partial protection in influenza-naïve ferrets after challenge with the influenza pandemic H1N1 A/The Netherlands/602/09 virus. Further, unlike saline control and non-adjuvanted vaccine, it was shown that immunization of naïve ferrets with an AS03-adjuvanted pandemic H1N1 A/California/7/09 influenza split vaccine induced increased antibody response and enhanced protection against the challenge strain, including significant reduction in viral shedding in the upper respiratory tract and reduced lung pathology post-challenge. These results show the need for vaccination with the adjuvanted vaccine to fully protect against viral replication and influenza disease in unprimed ferrets.</description><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Applied microbiology</subject><subject>AS03</subject><subject>Avian flu</subject><subject>Biological and medical sciences</subject><subject>Ferret</subject><subject>Ferrets</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>H1N1</subject><subject>Histology</subject><subject>Histopathology</subject><subject>Immunization</subject><subject>Influenza A Virus, H1N1 Subtype - immunology</subject><subject>Influenza A Virus, H1N1 Subtype - physiology</subject><subject>Influenza A Virus, H5N1 Subtype - immunology</subject><subject>Influenza A Virus, H5N1 Subtype - physiology</subject><subject>Influenza Vaccines - immunology</subject><subject>Lung - pathology</subject><subject>Lung - virology</subject><subject>Microbiology</subject><subject>Neutralization Tests</subject><subject>Orthomyxoviridae Infections - immunology</subject><subject>Orthomyxoviridae Infections - prevention & control</subject><subject>Pandemics</subject><subject>Pathology</subject><subject>Respiratory tract</subject><subject>Swine flu</subject><subject>Vaccine</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Viral Load</subject><subject>Virus Replication</subject><subject>Virus Shedding</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkt1qFTEUhYMo9lh9BCUg4tUc8zc_uVGkWCsUFVTwLuzJ7Gkzzsm0SeZAn6oP4YuZ4YwWemPYEAjfXllZO4Q852zLGa_eDNs9WOs8bgVbzkSu8gHZ8KaWhSh585BsmKhUoTj7eUSexDgwxkrJ9WNyJLiQTVnLDem-gu9w5yw94585XTVpwOvZBYw0XSKdI9Kpp-ApdMO8B59omuhVmBLaROECnI-J2ksYR_QXSJ2nHn7f7pH2GAKm-JQ86mGM-Gzdj8mP0w_fT86K8y8fP528Py-squtUSFVyBYJrDqIChbpFbJHLTvdVVbcq-8dSCssaUAKBSY1WtVqJptPKCi2PyeuDbvZ2PWNMZueixXEEj9McTVMqWWsuq0y-vEcO0xx8Nme40g3nTDUsU-WBsmGKMWBvroLbQbgxnJllCmYwa2JmmYLhIleZ-16s6nO7w-5f19_YM_BqBSBaGPsA3rp4x0kthGaLzXcHDnNqe4fBROvQW-zycGwy3eT-a-XtPQU7Ou_ypb_wBuPdq00Uhplvy5dZfkxOIK-qlH8AxYm8FQ</recordid><startdate>20110303</startdate><enddate>20110303</enddate><creator>Baras, Benoît</creator><creator>de Waal, Leon</creator><creator>Stittelaar, Koert J</creator><creator>Jacob, Valérie</creator><creator>Giannini, Sandra</creator><creator>Veldhuis Kroeze, Edwin J.B</creator><creator>van den Brand, Judith M.A</creator><creator>van Amerongen, Geert</creator><creator>Simon, James H</creator><creator>Hanon, Emmanuel</creator><creator>Mossman, Sally P</creator><creator>Osterhaus, Albert D.M.E</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20110303</creationdate><title>Pandemic H1N1 vaccine requires the use of an adjuvant to protect against challenge in naïve ferrets</title><author>Baras, Benoît ; de Waal, Leon ; Stittelaar, Koert J ; Jacob, Valérie ; Giannini, Sandra ; Veldhuis Kroeze, Edwin J.B ; van den Brand, Judith M.A ; van Amerongen, Geert ; Simon, James H ; Hanon, Emmanuel ; Mossman, Sally P ; Osterhaus, Albert D.M.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-34514a2191a26a4e9beebe13d9f667b4000e532c08a42ea039ec4b9428d94c293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>Applied microbiology</topic><topic>AS03</topic><topic>Avian flu</topic><topic>Biological and medical sciences</topic><topic>Ferret</topic><topic>Ferrets</topic><topic>Fundamental and applied biological sciences. 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Further, unlike saline control and non-adjuvanted vaccine, it was shown that immunization of naïve ferrets with an AS03-adjuvanted pandemic H1N1 A/California/7/09 influenza split vaccine induced increased antibody response and enhanced protection against the challenge strain, including significant reduction in viral shedding in the upper respiratory tract and reduced lung pathology post-challenge. These results show the need for vaccination with the adjuvanted vaccine to fully protect against viral replication and influenza disease in unprimed ferrets.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21238573</pmid><doi>10.1016/j.vaccine.2010.12.125</doi><tpages>7</tpages></addata></record> |
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| subjects | Adjuvants, Immunologic - pharmacology Allergy and Immunology Animals Antibodies, Viral - blood Applied microbiology AS03 Avian flu Biological and medical sciences Ferret Ferrets Fundamental and applied biological sciences. Psychology H1N1 Histology Histopathology Immunization Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H1N1 Subtype - physiology Influenza A Virus, H5N1 Subtype - immunology Influenza A Virus, H5N1 Subtype - physiology Influenza Vaccines - immunology Lung - pathology Lung - virology Microbiology Neutralization Tests Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Pandemics Pathology Respiratory tract Swine flu Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral Load Virus Replication Virus Shedding |
| title | Pandemic H1N1 vaccine requires the use of an adjuvant to protect against challenge in naïve ferrets |
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