Argon plasma coagulation treatment of hemorrhagic radiation proctopathy: the optimal settings for application and long-term outcome
Background No standard treatment exists for hemorrhagic radiation proctopathy (HRP). Recently it was reported that argon plasma coagulation (APC) is effective for HRP. However, previous studies documented complications such as ulcers, strictures, and perforations in as many as 20% of APC-treated pat...
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| creator | Sato, Yasushi, MD, PhD Takayama, Tetsuji, MD, PhD Sagawa, Tamotsu, MD, PhD Hirakawa, Masahiro, MD Ohnuma, Hiroyuki, MD, PhD Miyanishi, Koji, MD, PhD Sato, Tsutomu, MD, PhD Takimoto, Rishu, MD, PhD Kobune, Masayoshi, MD, PhD Okamoto, Koichi, MD, PhD Takeuchi, Hisashi, MD Kato, Junji, MD, PhD |
| description | Background No standard treatment exists for hemorrhagic radiation proctopathy (HRP). Recently it was reported that argon plasma coagulation (APC) is effective for HRP. However, previous studies documented complications such as ulcers, strictures, and perforations in as many as 20% of APC-treated patients. Objective The aim of this study was to determine the optimal parameters for APC by using swine rectum and to assess the safety and effectiveness of APC in HRP patients. Design Prospective case series. Setting University teaching hospital. Patients Sixty-five patients with HRP were prospectively enrolled between 2000 and 2010. Interventions APC for HRP. Main Outcome Measurements Optimal APC parameters, number of treatments, success rate, complications, clinical remissions. Results APC in swine rectal wall ex vivo was optimal with a 40-W current, 1.2-L/min gas flow rate, and 2-second application, which was sufficient to treat the submucosal telangiectasia but did not adversely affect the muscle layer. Sixty-five patients (46 men, 19 women; median age 72 years) with HRP occurring at a mean of 20 months after radiotherapy were studied. Proctopathy was classified as grade A (mild) in 7 patients (10.8%), grade B (moderate) in 41 (63.1%), and grade C (severe) in 17 (26.2%). The treatment success rate was 98.5% after a median of 2 (range 1-5) APC sessions. The median clinical score for rectal bleeding was significantly decreased after APC ( P < .0001), and the hemoglobin level was significantly increased ( P < .0001). APC was well tolerated, and no significant side effects or complications occurred. During a mean follow-up of 34.6 months (range 3.6 –121.1 months), 4 patients (6.3%) had minor recurrent rectal bleeding and 60 (93.8%) remained in remission. Limitations Nonrandomized study. Conclusions HRP treatment with optimal APC settings yields a high success rate and long-lasting clinical remission with no significant complications. |
| doi_str_mv | 10.1016/j.gie.2010.11.015 |
| format | Article |
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Recently it was reported that argon plasma coagulation (APC) is effective for HRP. However, previous studies documented complications such as ulcers, strictures, and perforations in as many as 20% of APC-treated patients. Objective The aim of this study was to determine the optimal parameters for APC by using swine rectum and to assess the safety and effectiveness of APC in HRP patients. Design Prospective case series. Setting University teaching hospital. Patients Sixty-five patients with HRP were prospectively enrolled between 2000 and 2010. Interventions APC for HRP. Main Outcome Measurements Optimal APC parameters, number of treatments, success rate, complications, clinical remissions. Results APC in swine rectal wall ex vivo was optimal with a 40-W current, 1.2-L/min gas flow rate, and 2-second application, which was sufficient to treat the submucosal telangiectasia but did not adversely affect the muscle layer. Sixty-five patients (46 men, 19 women; median age 72 years) with HRP occurring at a mean of 20 months after radiotherapy were studied. Proctopathy was classified as grade A (mild) in 7 patients (10.8%), grade B (moderate) in 41 (63.1%), and grade C (severe) in 17 (26.2%). The treatment success rate was 98.5% after a median of 2 (range 1-5) APC sessions. The median clinical score for rectal bleeding was significantly decreased after APC ( P < .0001), and the hemoglobin level was significantly increased ( P < .0001). APC was well tolerated, and no significant side effects or complications occurred. During a mean follow-up of 34.6 months (range 3.6 –121.1 months), 4 patients (6.3%) had minor recurrent rectal bleeding and 60 (93.8%) remained in remission. Limitations Nonrandomized study. Conclusions HRP treatment with optimal APC settings yields a high success rate and long-lasting clinical remission with no significant complications.</description><identifier>ISSN: 0016-5107</identifier><identifier>EISSN: 1097-6779</identifier><identifier>DOI: 10.1016/j.gie.2010.11.015</identifier><identifier>PMID: 21257166</identifier><identifier>CODEN: GAENBQ</identifier><language>eng</language><publisher>Maryland heights, MO: Mosby, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Animals ; Argon Plasma Coagulation - methods ; Biological and medical sciences ; Digestive system. Abdomen ; Endoscopy ; Female ; Gastroenterology and Hepatology ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal Hemorrhage - etiology ; Gastrointestinal Hemorrhage - surgery ; Humans ; Intestinal Mucosa - surgery ; Investigative techniques, diagnostic techniques (general aspects) ; Lasers, Gas - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Prospective Studies ; Prostatic Neoplasms - radiotherapy ; Radiation Injuries - complications ; Rectum - pathology ; Rectum - radiation effects ; Rectum - surgery ; Statistics, Nonparametric ; Swine ; Treatment Outcome ; Uterine Cervical Neoplasms - radiotherapy</subject><ispartof>Gastrointestinal endoscopy, 2011-03, Vol.73 (3), p.543-549</ispartof><rights>American Society for Gastrointestinal Endoscopy</rights><rights>2011 American Society for Gastrointestinal Endoscopy</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-a25e0a8cc51f7c7b3b9bb2355cf8db2e07e2f817b0ab4483fd98b0e7b37f3fb23</citedby><cites>FETCH-LOGICAL-c503t-a25e0a8cc51f7c7b3b9bb2355cf8db2e07e2f817b0ab4483fd98b0e7b37f3fb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.gie.2010.11.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23917512$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21257166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Yasushi, MD, PhD</creatorcontrib><creatorcontrib>Takayama, Tetsuji, MD, PhD</creatorcontrib><creatorcontrib>Sagawa, Tamotsu, MD, PhD</creatorcontrib><creatorcontrib>Hirakawa, Masahiro, MD</creatorcontrib><creatorcontrib>Ohnuma, Hiroyuki, MD, PhD</creatorcontrib><creatorcontrib>Miyanishi, Koji, MD, PhD</creatorcontrib><creatorcontrib>Sato, Tsutomu, MD, PhD</creatorcontrib><creatorcontrib>Takimoto, Rishu, MD, PhD</creatorcontrib><creatorcontrib>Kobune, Masayoshi, MD, PhD</creatorcontrib><creatorcontrib>Okamoto, Koichi, MD, PhD</creatorcontrib><creatorcontrib>Takeuchi, Hisashi, MD</creatorcontrib><creatorcontrib>Kato, Junji, MD, PhD</creatorcontrib><title>Argon plasma coagulation treatment of hemorrhagic radiation proctopathy: the optimal settings for application and long-term outcome</title><title>Gastrointestinal endoscopy</title><addtitle>Gastrointest Endosc</addtitle><description>Background No standard treatment exists for hemorrhagic radiation proctopathy (HRP). Recently it was reported that argon plasma coagulation (APC) is effective for HRP. However, previous studies documented complications such as ulcers, strictures, and perforations in as many as 20% of APC-treated patients. Objective The aim of this study was to determine the optimal parameters for APC by using swine rectum and to assess the safety and effectiveness of APC in HRP patients. Design Prospective case series. Setting University teaching hospital. Patients Sixty-five patients with HRP were prospectively enrolled between 2000 and 2010. Interventions APC for HRP. Main Outcome Measurements Optimal APC parameters, number of treatments, success rate, complications, clinical remissions. Results APC in swine rectal wall ex vivo was optimal with a 40-W current, 1.2-L/min gas flow rate, and 2-second application, which was sufficient to treat the submucosal telangiectasia but did not adversely affect the muscle layer. Sixty-five patients (46 men, 19 women; median age 72 years) with HRP occurring at a mean of 20 months after radiotherapy were studied. Proctopathy was classified as grade A (mild) in 7 patients (10.8%), grade B (moderate) in 41 (63.1%), and grade C (severe) in 17 (26.2%). The treatment success rate was 98.5% after a median of 2 (range 1-5) APC sessions. The median clinical score for rectal bleeding was significantly decreased after APC ( P < .0001), and the hemoglobin level was significantly increased ( P < .0001). APC was well tolerated, and no significant side effects or complications occurred. During a mean follow-up of 34.6 months (range 3.6 –121.1 months), 4 patients (6.3%) had minor recurrent rectal bleeding and 60 (93.8%) remained in remission. Limitations Nonrandomized study. Conclusions HRP treatment with optimal APC settings yields a high success rate and long-lasting clinical remission with no significant complications.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Animals</subject><subject>Argon Plasma Coagulation - methods</subject><subject>Biological and medical sciences</subject><subject>Digestive system. Abdomen</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal Hemorrhage - etiology</subject><subject>Gastrointestinal Hemorrhage - surgery</subject><subject>Humans</subject><subject>Intestinal Mucosa - surgery</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lasers, Gas - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Prostatic Neoplasms - radiotherapy</subject><subject>Radiation Injuries - complications</subject><subject>Rectum - pathology</subject><subject>Rectum - radiation effects</subject><subject>Rectum - surgery</subject><subject>Statistics, Nonparametric</subject><subject>Swine</subject><subject>Treatment Outcome</subject><subject>Uterine Cervical Neoplasms - radiotherapy</subject><issn>0016-5107</issn><issn>1097-6779</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk2r1DAUhoMo3vHqD3Aj2YirjjnptGkVhMvFL7jgQl2HND3pZEybmqTCrP3jpnRUcOEqJDzv4c3DIeQpsD0wqF-e9oPFPWfrHfYMqntkB6wVRS1Ee5_sWIaKCpi4Io9iPDHGGl7CQ3LFgVcC6npHft6EwU90diqOimqvhsWpZPNTCqjSiFOi3tAjjj6EoxqspkH1dkPm4HXys0rH8yuajkj9nOyoHI2Ykp2GSI0PVM2zs3pLqKmnzk9DkTCM1C9J-xEfkwdGuYhPLuc1-fru7ZfbD8Xdp_cfb2_uCl2xMhWKV8hUo3UFRmjRlV3bdbysKm2avuPIBHLTgOiY6g6HpjR923QMMyhMaTJ5TV5sc3Pv7wvGJEcbNTqnJvRLlE11KEVdwyGTsJE6-BgDGjmH_LFwlsDkql6eZFYvV_USQGb1OfPsMn3pRuz_JH67zsDzC6CiVs4ENWkb_3JlC6KCtebrjcPs4ofFIKO2OGnsbUCdZO_tf2u8-SetnZ2yf_cNzxhPfglTlixBRi6Z_LzuyLoiwBgvOW_LX6znuXw</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Sato, Yasushi, MD, PhD</creator><creator>Takayama, Tetsuji, MD, PhD</creator><creator>Sagawa, Tamotsu, MD, PhD</creator><creator>Hirakawa, Masahiro, MD</creator><creator>Ohnuma, Hiroyuki, MD, PhD</creator><creator>Miyanishi, Koji, MD, PhD</creator><creator>Sato, Tsutomu, MD, PhD</creator><creator>Takimoto, Rishu, MD, PhD</creator><creator>Kobune, Masayoshi, MD, PhD</creator><creator>Okamoto, Koichi, MD, PhD</creator><creator>Takeuchi, Hisashi, MD</creator><creator>Kato, Junji, MD, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110301</creationdate><title>Argon plasma coagulation treatment of hemorrhagic radiation proctopathy: the optimal settings for application and long-term outcome</title><author>Sato, Yasushi, MD, PhD ; Takayama, Tetsuji, MD, PhD ; Sagawa, Tamotsu, MD, PhD ; Hirakawa, Masahiro, MD ; Ohnuma, Hiroyuki, MD, PhD ; Miyanishi, Koji, MD, PhD ; Sato, Tsutomu, MD, PhD ; Takimoto, Rishu, MD, PhD ; Kobune, Masayoshi, MD, PhD ; Okamoto, Koichi, MD, PhD ; Takeuchi, Hisashi, MD ; Kato, Junji, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-a25e0a8cc51f7c7b3b9bb2355cf8db2e07e2f817b0ab4483fd98b0e7b37f3fb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Animals</topic><topic>Argon Plasma Coagulation - methods</topic><topic>Biological and medical sciences</topic><topic>Digestive system. Abdomen</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastrointestinal Hemorrhage - etiology</topic><topic>Gastrointestinal Hemorrhage - surgery</topic><topic>Humans</topic><topic>Intestinal Mucosa - surgery</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lasers, Gas - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Prostatic Neoplasms - radiotherapy</topic><topic>Radiation Injuries - complications</topic><topic>Rectum - pathology</topic><topic>Rectum - radiation effects</topic><topic>Rectum - surgery</topic><topic>Statistics, Nonparametric</topic><topic>Swine</topic><topic>Treatment Outcome</topic><topic>Uterine Cervical Neoplasms - radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Yasushi, MD, PhD</creatorcontrib><creatorcontrib>Takayama, Tetsuji, MD, PhD</creatorcontrib><creatorcontrib>Sagawa, Tamotsu, MD, PhD</creatorcontrib><creatorcontrib>Hirakawa, Masahiro, MD</creatorcontrib><creatorcontrib>Ohnuma, Hiroyuki, MD, PhD</creatorcontrib><creatorcontrib>Miyanishi, Koji, MD, PhD</creatorcontrib><creatorcontrib>Sato, Tsutomu, MD, PhD</creatorcontrib><creatorcontrib>Takimoto, Rishu, MD, PhD</creatorcontrib><creatorcontrib>Kobune, Masayoshi, MD, PhD</creatorcontrib><creatorcontrib>Okamoto, Koichi, MD, PhD</creatorcontrib><creatorcontrib>Takeuchi, Hisashi, MD</creatorcontrib><creatorcontrib>Kato, Junji, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastrointestinal endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Yasushi, MD, PhD</au><au>Takayama, Tetsuji, MD, PhD</au><au>Sagawa, Tamotsu, MD, PhD</au><au>Hirakawa, Masahiro, MD</au><au>Ohnuma, Hiroyuki, MD, PhD</au><au>Miyanishi, Koji, MD, PhD</au><au>Sato, Tsutomu, MD, PhD</au><au>Takimoto, Rishu, MD, PhD</au><au>Kobune, Masayoshi, MD, PhD</au><au>Okamoto, Koichi, MD, PhD</au><au>Takeuchi, Hisashi, MD</au><au>Kato, Junji, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Argon plasma coagulation treatment of hemorrhagic radiation proctopathy: the optimal settings for application and long-term outcome</atitle><jtitle>Gastrointestinal endoscopy</jtitle><addtitle>Gastrointest Endosc</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>73</volume><issue>3</issue><spage>543</spage><epage>549</epage><pages>543-549</pages><issn>0016-5107</issn><eissn>1097-6779</eissn><coden>GAENBQ</coden><abstract>Background No standard treatment exists for hemorrhagic radiation proctopathy (HRP). Recently it was reported that argon plasma coagulation (APC) is effective for HRP. However, previous studies documented complications such as ulcers, strictures, and perforations in as many as 20% of APC-treated patients. Objective The aim of this study was to determine the optimal parameters for APC by using swine rectum and to assess the safety and effectiveness of APC in HRP patients. Design Prospective case series. Setting University teaching hospital. Patients Sixty-five patients with HRP were prospectively enrolled between 2000 and 2010. Interventions APC for HRP. Main Outcome Measurements Optimal APC parameters, number of treatments, success rate, complications, clinical remissions. Results APC in swine rectal wall ex vivo was optimal with a 40-W current, 1.2-L/min gas flow rate, and 2-second application, which was sufficient to treat the submucosal telangiectasia but did not adversely affect the muscle layer. Sixty-five patients (46 men, 19 women; median age 72 years) with HRP occurring at a mean of 20 months after radiotherapy were studied. Proctopathy was classified as grade A (mild) in 7 patients (10.8%), grade B (moderate) in 41 (63.1%), and grade C (severe) in 17 (26.2%). The treatment success rate was 98.5% after a median of 2 (range 1-5) APC sessions. The median clinical score for rectal bleeding was significantly decreased after APC ( P < .0001), and the hemoglobin level was significantly increased ( P < .0001). APC was well tolerated, and no significant side effects or complications occurred. During a mean follow-up of 34.6 months (range 3.6 –121.1 months), 4 patients (6.3%) had minor recurrent rectal bleeding and 60 (93.8%) remained in remission. Limitations Nonrandomized study. Conclusions HRP treatment with optimal APC settings yields a high success rate and long-lasting clinical remission with no significant complications.</abstract><cop>Maryland heights, MO</cop><pub>Mosby, Inc</pub><pmid>21257166</pmid><doi>10.1016/j.gie.2010.11.015</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Animals Argon Plasma Coagulation - methods Biological and medical sciences Digestive system. Abdomen Endoscopy Female Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Hemorrhage - etiology Gastrointestinal Hemorrhage - surgery Humans Intestinal Mucosa - surgery Investigative techniques, diagnostic techniques (general aspects) Lasers, Gas - therapeutic use Male Medical sciences Middle Aged Prospective Studies Prostatic Neoplasms - radiotherapy Radiation Injuries - complications Rectum - pathology Rectum - radiation effects Rectum - surgery Statistics, Nonparametric Swine Treatment Outcome Uterine Cervical Neoplasms - radiotherapy |
| title | Argon plasma coagulation treatment of hemorrhagic radiation proctopathy: the optimal settings for application and long-term outcome |
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