Effects of maternal malnutrition and postnatal nutritional rehabilitation on brain fatty acids, learning, and memory
Undernutrition still affects mothers and children in developing countries and thus remains the major focus of nutritional intervention efforts. Neuronal development, which classically includes neurogenesis, migration, maturation, and synapse refinement, begins in utero and continues into the early p...
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| Veröffentlicht in: | Nutrition reviews 2011-03, Vol.69 (3), p.132-144 |
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| creator | de Souza, Amanda Santos Fernandes, Flávia Spreafico Tavares do Carmo, Maria das Graças |
| description | Undernutrition still affects mothers and children in developing countries and thus remains the major focus of nutritional intervention efforts. Neuronal development, which classically includes neurogenesis, migration, maturation, and synapse refinement, begins in utero and continues into the early postnatal period. These processes are not only genetically regulated but also clearly susceptible to environmental manipulation. Dietary deprivation during early life is known to have adverse effects on brain anatomy, physiology, and biochemistry, and may even lead to permanent brain damage. Although all nutrients are important for the structural development of the central nervous system, lipids such as long‐chain polyunsaturated fatty acids, especially docosahexaenoic acid (22:6 n‐3) and arachidonic acid (20:4 n‐6), are important for normal brain development. The purpose of this literature review is to examine how early undernutrition involving a deficiency in long‐chain polyunsaturated fatty acids can affect brain development and function and produce deficits in spatial cognitive learning ability. |
| doi_str_mv | 10.1111/j.1753-4887.2011.00374.x |
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Neuronal development, which classically includes neurogenesis, migration, maturation, and synapse refinement, begins in utero and continues into the early postnatal period. These processes are not only genetically regulated but also clearly susceptible to environmental manipulation. Dietary deprivation during early life is known to have adverse effects on brain anatomy, physiology, and biochemistry, and may even lead to permanent brain damage. Although all nutrients are important for the structural development of the central nervous system, lipids such as long‐chain polyunsaturated fatty acids, especially docosahexaenoic acid (22:6 n‐3) and arachidonic acid (20:4 n‐6), are important for normal brain development. The purpose of this literature review is to examine how early undernutrition involving a deficiency in long‐chain polyunsaturated fatty acids can affect brain development and function and produce deficits in spatial cognitive learning ability.</description><identifier>ISSN: 0029-6643</identifier><identifier>EISSN: 1753-4887</identifier><identifier>DOI: 10.1111/j.1753-4887.2011.00374.x</identifier><identifier>PMID: 21348877</identifier><identifier>CODEN: NUREA8</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Arachidonic acid ; Biological and medical sciences ; Brain ; Brain - drug effects ; Brain - growth & development ; Brain - metabolism ; Brain - physiology ; brain fatty acids ; Cell migration ; Central nervous system ; Children ; Cognitive ability ; Developing countries ; Diet ; Docosahexaenoic acid ; Fatty acids ; Fatty Acids, Unsaturated - metabolism ; Fatty Acids, Unsaturated - therapeutic use ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Infant Nutrition Disorders - diet therapy ; Infant Nutritional Physiological Phenomena - physiology ; Infant, Newborn ; Intervention ; Learning ; Learning - physiology ; Lipids ; Literature reviews ; Malnutrition ; Malnutrition - complications ; Malnutrition - metabolism ; Maternal & child health ; Maternal Nutritional Physiological Phenomena - physiology ; Memory ; Memory - physiology ; Neurogenesis ; Nutrients ; nutritional rehabilitation ; Polyunsaturated fatty acids ; Pregnancy ; Prenatal Nutritional Physiological Phenomena - physiology ; Side effects ; spatial memory ; Synapses ; Undernutrition ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Nutrition reviews, 2011-03, Vol.69 (3), p.132-144</ispartof><rights>2011 International Life Sciences Institute</rights><rights>2015 INIST-CNRS</rights><rights>2011 International Life Sciences Institute.</rights><rights>Copyright International Life Sciences Institute Mar 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4974-858d89b338063918d757b66f9005f988a07eb6f63b7c01fc2b8e55995244fa623</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1753-4887.2011.00374.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1753-4887.2011.00374.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23931214$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21348877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Souza, Amanda Santos</creatorcontrib><creatorcontrib>Fernandes, Flávia Spreafico</creatorcontrib><creatorcontrib>Tavares do Carmo, Maria das Graças</creatorcontrib><title>Effects of maternal malnutrition and postnatal nutritional rehabilitation on brain fatty acids, learning, and memory</title><title>Nutrition reviews</title><addtitle>Nutr Rev</addtitle><description>Undernutrition still affects mothers and children in developing countries and thus remains the major focus of nutritional intervention efforts. Neuronal development, which classically includes neurogenesis, migration, maturation, and synapse refinement, begins in utero and continues into the early postnatal period. These processes are not only genetically regulated but also clearly susceptible to environmental manipulation. Dietary deprivation during early life is known to have adverse effects on brain anatomy, physiology, and biochemistry, and may even lead to permanent brain damage. Although all nutrients are important for the structural development of the central nervous system, lipids such as long‐chain polyunsaturated fatty acids, especially docosahexaenoic acid (22:6 n‐3) and arachidonic acid (20:4 n‐6), are important for normal brain development. The purpose of this literature review is to examine how early undernutrition involving a deficiency in long‐chain polyunsaturated fatty acids can affect brain development and function and produce deficits in spatial cognitive learning ability.</description><subject>Arachidonic acid</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>Brain - physiology</subject><subject>brain fatty acids</subject><subject>Cell migration</subject><subject>Central nervous system</subject><subject>Children</subject><subject>Cognitive ability</subject><subject>Developing countries</subject><subject>Diet</subject><subject>Docosahexaenoic acid</subject><subject>Fatty acids</subject><subject>Fatty Acids, Unsaturated - metabolism</subject><subject>Fatty Acids, Unsaturated - therapeutic use</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infant Nutrition Disorders - diet therapy</subject><subject>Infant Nutritional Physiological Phenomena - physiology</subject><subject>Infant, Newborn</subject><subject>Intervention</subject><subject>Learning</subject><subject>Learning - physiology</subject><subject>Lipids</subject><subject>Literature reviews</subject><subject>Malnutrition</subject><subject>Malnutrition - complications</subject><subject>Malnutrition - metabolism</subject><subject>Maternal & child health</subject><subject>Maternal Nutritional Physiological Phenomena - physiology</subject><subject>Memory</subject><subject>Memory - physiology</subject><subject>Neurogenesis</subject><subject>Nutrients</subject><subject>nutritional rehabilitation</subject><subject>Polyunsaturated fatty acids</subject><subject>Pregnancy</subject><subject>Prenatal Nutritional Physiological Phenomena - physiology</subject><subject>Side effects</subject><subject>spatial memory</subject><subject>Synapses</subject><subject>Undernutrition</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0029-6643</issn><issn>1753-4887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kkuP0zAUhS0EYjoDfwFFSAgWk-BH_FrMAo3KACqDBIxYWk5ig0viFNvRtP8epy1FYoFly1c-3z2L6wNAgWCF8nq9rhCnpKyF4BWGCFUQEl5X2wdgcRIeggWEWJaM1eQMnMe4hhAiLMljcIYRmRG-AGlprWlTLEZbDDqZ4HWfi95PKbjkRl9o3xWbMSavU5ZO77kO5oduXO-S3oN5N0E7X1id0q7QreviZdEbHbzz3y_3RoMZxrB7Ah5Z3Ufz9HhfgLu3y6_X78rVp5v3129WZVtLXpeCik7IhhABGZFIdJzyhjErIaRWCqEhNw2zjDS8hci2uBGGUikprmurGSYX4OXBdxPGX5OJSQ0utqbvtTfjFJWgREoO8Uy--i-JMBEIM0ZhRp__g67HaR7b7EcJzqfO0LMjNDWD6dQmuEGHnfoz-Ay8OAI6trq3QfvWxb8ckQRhNBtdHbh715vdSUdQzUFQazX_t5o91RwEtQ-C2qrbu8_LXOX-8tDvYjLbU78OPxXjhFP17fZGrfBHySD_oL6Q3yO-tGE</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>de Souza, Amanda Santos</creator><creator>Fernandes, Flávia Spreafico</creator><creator>Tavares do Carmo, Maria das Graças</creator><general>Blackwell Publishing Inc</general><general>Wiley</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>201103</creationdate><title>Effects of maternal malnutrition and postnatal nutritional rehabilitation on brain fatty acids, learning, and memory</title><author>de Souza, Amanda Santos ; Fernandes, Flávia Spreafico ; Tavares do Carmo, Maria das Graças</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4974-858d89b338063918d757b66f9005f988a07eb6f63b7c01fc2b8e55995244fa623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Arachidonic acid</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - drug effects</topic><topic>Brain - growth & development</topic><topic>Brain - metabolism</topic><topic>Brain - physiology</topic><topic>brain fatty acids</topic><topic>Cell migration</topic><topic>Central nervous system</topic><topic>Children</topic><topic>Cognitive ability</topic><topic>Developing countries</topic><topic>Diet</topic><topic>Docosahexaenoic acid</topic><topic>Fatty acids</topic><topic>Fatty Acids, Unsaturated - metabolism</topic><topic>Fatty Acids, Unsaturated - therapeutic use</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infant Nutrition Disorders - diet therapy</topic><topic>Infant Nutritional Physiological Phenomena - physiology</topic><topic>Infant, Newborn</topic><topic>Intervention</topic><topic>Learning</topic><topic>Learning - physiology</topic><topic>Lipids</topic><topic>Literature reviews</topic><topic>Malnutrition</topic><topic>Malnutrition - complications</topic><topic>Malnutrition - metabolism</topic><topic>Maternal & child health</topic><topic>Maternal Nutritional Physiological Phenomena - physiology</topic><topic>Memory</topic><topic>Memory - physiology</topic><topic>Neurogenesis</topic><topic>Nutrients</topic><topic>nutritional rehabilitation</topic><topic>Polyunsaturated fatty acids</topic><topic>Pregnancy</topic><topic>Prenatal Nutritional Physiological Phenomena - physiology</topic><topic>Side effects</topic><topic>spatial memory</topic><topic>Synapses</topic><topic>Undernutrition</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Souza, Amanda Santos</creatorcontrib><creatorcontrib>Fernandes, Flávia Spreafico</creatorcontrib><creatorcontrib>Tavares do Carmo, Maria das Graças</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Souza, Amanda Santos</au><au>Fernandes, Flávia Spreafico</au><au>Tavares do Carmo, Maria das Graças</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of maternal malnutrition and postnatal nutritional rehabilitation on brain fatty acids, learning, and memory</atitle><jtitle>Nutrition reviews</jtitle><addtitle>Nutr Rev</addtitle><date>2011-03</date><risdate>2011</risdate><volume>69</volume><issue>3</issue><spage>132</spage><epage>144</epage><pages>132-144</pages><issn>0029-6643</issn><eissn>1753-4887</eissn><coden>NUREA8</coden><abstract>Undernutrition still affects mothers and children in developing countries and thus remains the major focus of nutritional intervention efforts. Neuronal development, which classically includes neurogenesis, migration, maturation, and synapse refinement, begins in utero and continues into the early postnatal period. These processes are not only genetically regulated but also clearly susceptible to environmental manipulation. Dietary deprivation during early life is known to have adverse effects on brain anatomy, physiology, and biochemistry, and may even lead to permanent brain damage. Although all nutrients are important for the structural development of the central nervous system, lipids such as long‐chain polyunsaturated fatty acids, especially docosahexaenoic acid (22:6 n‐3) and arachidonic acid (20:4 n‐6), are important for normal brain development. The purpose of this literature review is to examine how early undernutrition involving a deficiency in long‐chain polyunsaturated fatty acids can affect brain development and function and produce deficits in spatial cognitive learning ability.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>21348877</pmid><doi>10.1111/j.1753-4887.2011.00374.x</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrition reviews, 2011-03, Vol.69 (3), p.132-144 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Arachidonic acid Biological and medical sciences Brain Brain - drug effects Brain - growth & development Brain - metabolism Brain - physiology brain fatty acids Cell migration Central nervous system Children Cognitive ability Developing countries Diet Docosahexaenoic acid Fatty acids Fatty Acids, Unsaturated - metabolism Fatty Acids, Unsaturated - therapeutic use Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Infant Nutrition Disorders - diet therapy Infant Nutritional Physiological Phenomena - physiology Infant, Newborn Intervention Learning Learning - physiology Lipids Literature reviews Malnutrition Malnutrition - complications Malnutrition - metabolism Maternal & child health Maternal Nutritional Physiological Phenomena - physiology Memory Memory - physiology Neurogenesis Nutrients nutritional rehabilitation Polyunsaturated fatty acids Pregnancy Prenatal Nutritional Physiological Phenomena - physiology Side effects spatial memory Synapses Undernutrition Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effects of maternal malnutrition and postnatal nutritional rehabilitation on brain fatty acids, learning, and memory |
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