Risk factors for drug resistance in pulmonary tuberculosis inpatients
Objective To analyze risk factors for drug resistance in pulmonary tuberculosis (PTB) inpatients. Methods Medical records of PTB inpatients in Chengdu Tuberculosis Hospital (CTH) from 2005 to 2007 were investigated retrospectively. A logistic regression model was used to analyze data. Results A tota...
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| Veröffentlicht in: | Journal of evidence-based medicine 2010-08, Vol.3 (3), p.162-167 |
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| creator | Yang, Xiaoyan Li, Youping Wen, Xianmin Wu, Guihui Li, Xi |
| description | Objective To analyze risk factors for drug resistance in pulmonary tuberculosis (PTB) inpatients.
Methods Medical records of PTB inpatients in Chengdu Tuberculosis Hospital (CTH) from 2005 to 2007 were investigated retrospectively. A logistic regression model was used to analyze data.
Results A total of 330 records were included in the analysis. A history of tuberculosis treatment was associated with drug resistance with odds ratio (OR) 16.79 and 95% confidence interval (95% CI) [10.14, 27.80] for all patients. Among new patients, the significant risk factor was duration of illness (OR 0.27, 95% CI [0.16, 0.46]), and for previously treated patients, risk factors included age (OR 0.96, 95% CI [0.93, 0.99]), improper initial chemotherapy (OR 3.85, 95% CI [1.59, 10.00]), and improper handling by medical staff (OR 3.44, 95% CI [1.32, 8.96]).
Conclusions A history of drug treatment is associated with drug resistance among PTB inpatients. Initial resistance becomes increasingly serious till 2007. To minimize the development of resistance, more personalized treatment and supervision should be used, and better training for medical staff is needed. |
| doi_str_mv | 10.1111/j.1756-5391.2010.01088.x |
| format | Article |
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Methods Medical records of PTB inpatients in Chengdu Tuberculosis Hospital (CTH) from 2005 to 2007 were investigated retrospectively. A logistic regression model was used to analyze data.
Results A total of 330 records were included in the analysis. A history of tuberculosis treatment was associated with drug resistance with odds ratio (OR) 16.79 and 95% confidence interval (95% CI) [10.14, 27.80] for all patients. Among new patients, the significant risk factor was duration of illness (OR 0.27, 95% CI [0.16, 0.46]), and for previously treated patients, risk factors included age (OR 0.96, 95% CI [0.93, 0.99]), improper initial chemotherapy (OR 3.85, 95% CI [1.59, 10.00]), and improper handling by medical staff (OR 3.44, 95% CI [1.32, 8.96]).
Conclusions A history of drug treatment is associated with drug resistance among PTB inpatients. Initial resistance becomes increasingly serious till 2007. To minimize the development of resistance, more personalized treatment and supervision should be used, and better training for medical staff is needed.</description><identifier>ISSN: 1756-5383</identifier><identifier>ISSN: 1756-5391</identifier><identifier>EISSN: 1756-5391</identifier><identifier>DOI: 10.1111/j.1756-5391.2010.01088.x</identifier><identifier>PMID: 21349061</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Adult ; Antitubercular Agents - pharmacology ; Antitubercular Agents - therapeutic use ; China ; Drug resistance ; Drug Resistance, Microbial ; Female ; Humans ; Inpatients ; logistic regression ; Male ; Middle Aged ; multidrug-resistant tuberculosis (MDR-TB) ; Multivariate Analysis ; Mycobacterium tuberculosis - drug effects ; pulmonary tuberculosis ; Retrospective Studies ; Risk Factors ; Tuberculosis, Pulmonary - drug therapy ; Tuberculosis, Pulmonary - microbiology</subject><ispartof>Journal of evidence-based medicine, 2010-08, Vol.3 (3), p.162-167</ispartof><rights>2010 Blackwell Publishing Asia Pty Ltd and Chinese Cochrane Center, West China Hospital of Sichuan University</rights><rights>2010 Blackwell Publishing Asia Pty Ltd and Chinese Cochrane Center, West China Hospital of Sichuan University.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3728-e4ac2210ea7ec1b5ca6bd6c19c7ceae09c0a6ed9609a8cc7c8bb2da1034cb1de3</citedby><cites>FETCH-LOGICAL-c3728-e4ac2210ea7ec1b5ca6bd6c19c7ceae09c0a6ed9609a8cc7c8bb2da1034cb1de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1756-5391.2010.01088.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1756-5391.2010.01088.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21349061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Xiaoyan</creatorcontrib><creatorcontrib>Li, Youping</creatorcontrib><creatorcontrib>Wen, Xianmin</creatorcontrib><creatorcontrib>Wu, Guihui</creatorcontrib><creatorcontrib>Li, Xi</creatorcontrib><title>Risk factors for drug resistance in pulmonary tuberculosis inpatients</title><title>Journal of evidence-based medicine</title><addtitle>J Evid Based Med</addtitle><description>Objective To analyze risk factors for drug resistance in pulmonary tuberculosis (PTB) inpatients.
Methods Medical records of PTB inpatients in Chengdu Tuberculosis Hospital (CTH) from 2005 to 2007 were investigated retrospectively. A logistic regression model was used to analyze data.
Results A total of 330 records were included in the analysis. A history of tuberculosis treatment was associated with drug resistance with odds ratio (OR) 16.79 and 95% confidence interval (95% CI) [10.14, 27.80] for all patients. Among new patients, the significant risk factor was duration of illness (OR 0.27, 95% CI [0.16, 0.46]), and for previously treated patients, risk factors included age (OR 0.96, 95% CI [0.93, 0.99]), improper initial chemotherapy (OR 3.85, 95% CI [1.59, 10.00]), and improper handling by medical staff (OR 3.44, 95% CI [1.32, 8.96]).
Conclusions A history of drug treatment is associated with drug resistance among PTB inpatients. Initial resistance becomes increasingly serious till 2007. To minimize the development of resistance, more personalized treatment and supervision should be used, and better training for medical staff is needed.</description><subject>Adult</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>China</subject><subject>Drug resistance</subject><subject>Drug Resistance, Microbial</subject><subject>Female</subject><subject>Humans</subject><subject>Inpatients</subject><subject>logistic regression</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidrug-resistant tuberculosis (MDR-TB)</subject><subject>Multivariate Analysis</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>pulmonary tuberculosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><subject>Tuberculosis, Pulmonary - microbiology</subject><issn>1756-5383</issn><issn>1756-5391</issn><issn>1756-5391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1LwzAUhoMobsz9BcmdV61Js37dCE7mVLYpMqd3IU1PpVu_TFrc_r2pnb02EHI47zlveB-EMCU2Ned6a1Pf9SyXhdR2iOmaGwT2_gQNe-G0rwM2QGOt04hQnzLiuuQcDRzKJiHx6BDNXlO9w4mQdak0TkqFY9V8YgU61bUoJOC0wFWT5WUh1AHXTQRKNllpZKNUok6hqPUFOktEpmF8fEfo7X62vnuwFs_zx7vbhSWZ7wQWTIR0HEpA-CBp5ErhRbEnaSh9CQJIKInwIA49EopAmmYQRU4sKGETGdEY2Ahddb6VKr8a0DXPUy0hy0QBZaN5YLKHrmdCj1DQTUpVaq0g4ZVKcxOBU8JbjHzLW0K8pcVbjPwXI9-b1cvjJ02UQ9wv_kEzAzfdwHeaweHfxvxpNl22pTGwOgPDGPa9gVA77vnMd_n7as5X6810-cI--Ib9ANOBkm4</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Yang, Xiaoyan</creator><creator>Li, Youping</creator><creator>Wen, Xianmin</creator><creator>Wu, Guihui</creator><creator>Li, Xi</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201008</creationdate><title>Risk factors for drug resistance in pulmonary tuberculosis inpatients</title><author>Yang, Xiaoyan ; Li, Youping ; Wen, Xianmin ; Wu, Guihui ; Li, Xi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3728-e4ac2210ea7ec1b5ca6bd6c19c7ceae09c0a6ed9609a8cc7c8bb2da1034cb1de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>China</topic><topic>Drug resistance</topic><topic>Drug Resistance, Microbial</topic><topic>Female</topic><topic>Humans</topic><topic>Inpatients</topic><topic>logistic regression</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidrug-resistant tuberculosis (MDR-TB)</topic><topic>Multivariate Analysis</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>pulmonary tuberculosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Tuberculosis, Pulmonary - drug therapy</topic><topic>Tuberculosis, Pulmonary - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Xiaoyan</creatorcontrib><creatorcontrib>Li, Youping</creatorcontrib><creatorcontrib>Wen, Xianmin</creatorcontrib><creatorcontrib>Wu, Guihui</creatorcontrib><creatorcontrib>Li, Xi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of evidence-based medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Xiaoyan</au><au>Li, Youping</au><au>Wen, Xianmin</au><au>Wu, Guihui</au><au>Li, Xi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for drug resistance in pulmonary tuberculosis inpatients</atitle><jtitle>Journal of evidence-based medicine</jtitle><addtitle>J Evid Based Med</addtitle><date>2010-08</date><risdate>2010</risdate><volume>3</volume><issue>3</issue><spage>162</spage><epage>167</epage><pages>162-167</pages><issn>1756-5383</issn><issn>1756-5391</issn><eissn>1756-5391</eissn><abstract>Objective To analyze risk factors for drug resistance in pulmonary tuberculosis (PTB) inpatients.
Methods Medical records of PTB inpatients in Chengdu Tuberculosis Hospital (CTH) from 2005 to 2007 were investigated retrospectively. A logistic regression model was used to analyze data.
Results A total of 330 records were included in the analysis. A history of tuberculosis treatment was associated with drug resistance with odds ratio (OR) 16.79 and 95% confidence interval (95% CI) [10.14, 27.80] for all patients. Among new patients, the significant risk factor was duration of illness (OR 0.27, 95% CI [0.16, 0.46]), and for previously treated patients, risk factors included age (OR 0.96, 95% CI [0.93, 0.99]), improper initial chemotherapy (OR 3.85, 95% CI [1.59, 10.00]), and improper handling by medical staff (OR 3.44, 95% CI [1.32, 8.96]).
Conclusions A history of drug treatment is associated with drug resistance among PTB inpatients. Initial resistance becomes increasingly serious till 2007. To minimize the development of resistance, more personalized treatment and supervision should be used, and better training for medical staff is needed.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>21349061</pmid><doi>10.1111/j.1756-5391.2010.01088.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use China Drug resistance Drug Resistance, Microbial Female Humans Inpatients logistic regression Male Middle Aged multidrug-resistant tuberculosis (MDR-TB) Multivariate Analysis Mycobacterium tuberculosis - drug effects pulmonary tuberculosis Retrospective Studies Risk Factors Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - microbiology |
| title | Risk factors for drug resistance in pulmonary tuberculosis inpatients |
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