Lack of Beneficial Effect for Preemptive Analgesia in Postoperative Pain Control: Verifying the Efficacy of Preemptive Analgesia with N-Methyl-D-Aspartate Receptor Antagonists in a Modified Animal Model of Postoperative Pain

In previous animal studies, preemptive treatments with N-methyl-d-aspartate (NMDA) antagonists were ineffective at preventing incision-induced allodynia. It is very likely that the model was not clinically relevant for testing treatment effects on postoperative pain. The beneficial effects of preemp...

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Veröffentlicht in:	Anesthesia and analgesia 2011-03, Vol.112 (3), p.710-718
Hauptverfasser:	Chang, Wen-Kuei, Tao, Yuan-Xiang, Chuang, Chia-Chun, Chen, Pin-Tarng, Chan, Kowk-Hon, Chu, Ya-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia - methods Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Animals, Newborn Biological and medical sciences Disease Models, Animal Dizocilpine Maleate - administration & dosage Excitatory Amino Acid Antagonists - administration & dosage Female Male Medical sciences Pain Measurement - drug effects Pain Measurement - methods Pain, Postoperative - physiopathology Pain, Postoperative - prevention & control Pregnancy Preoperative Care - methods Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - biosynthesis
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