Newborn Screening for α-Thalassemia — Keeping Up with Globalization
Thalassemias are inherited disorders of hemoglobin synthesis. In α-thalassemia, the biosynthesis of the α-globin subunit of adult hemoglobin, hemoglobin A, is deficient. In β-thalassemia, β-globin synthesis is diminished. 1 Among the most common single-gene disorders in humans, thalassemias are a ca...
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 2011-02, Vol.364 (8), p.770-771 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 771 |
|---|---|
| container_issue | 8 |
| container_start_page | 770 |
| container_title | The New England journal of medicine |
| container_volume | 364 |
| creator | Benz, Edward J |
| description | Thalassemias are inherited disorders of hemoglobin synthesis. In α-thalassemia, the biosynthesis of the α-globin subunit of adult hemoglobin, hemoglobin A, is deficient. In β-thalassemia, β-globin synthesis is diminished.
1
Among the most common single-gene disorders in humans, thalassemias are a cause of substantial morbidity and mortality in Asia and the Mediterranean basin.
2
Symptomatic thalassemia has historically been an uncommon illness in the United States. However, as Lal et al. report in this issue of the
Journal,
3
a moderately severe symptomatic form of α-thalassemia, hemoglobin H (HbH) disease, is being encountered with increasing frequency as Asian migration increases to the West Coast . . . |
| doi_str_mv | 10.1056/NEJMe1013338 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_853993627</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>853993627</sourcerecordid><originalsourceid>FETCH-LOGICAL-c319t-df849c8c2c031a23cee5936d5e635d75be323ff1dcc259dc0a1f7c6ac2fc2e6f3</originalsourceid><addsrcrecordid>eNptkLtOwzAUhi0EoqWwMaMMSCwEbJ84lxFVbbmUMtDOkeMc01S5YaeqYOIheBFehIfgSUjVghg4yz-cT9_wEXLM6AWjwr-cDG7vkVEGAOEO6TIB4Hoe9XdJl1Ieul4QQYccWLug7TEv2icdzsATjIZdMpzgKqlM6Twqg1hm5ZOjK-N8frjTucyltVhk0vl6e3fuEOv1e1Y7q6yZO6O8SmSevcomq8pDsqdlbvFouz0yGw6m_Wt3_DC66V-NXQUsatxUh16kQsUVBSY5KEQRgZ8K9EGkgUgQOGjNUqW4iFJFJdOB8qXiWnH0NfTI2cZbm-p5ibaJi8wqzHNZYrW0cSggaoU8aMnzDalMZa1BHdcmK6R5iRmN1-Hiv-Fa_GQrXiYFpr_wT6kWON0ARWHjEhfF_55viXx1FQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>853993627</pqid></control><display><type>article</type><title>Newborn Screening for α-Thalassemia — Keeping Up with Globalization</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>New England Journal of Medicine</source><creator>Benz, Edward J</creator><creatorcontrib>Benz, Edward J</creatorcontrib><description>Thalassemias are inherited disorders of hemoglobin synthesis. In α-thalassemia, the biosynthesis of the α-globin subunit of adult hemoglobin, hemoglobin A, is deficient. In β-thalassemia, β-globin synthesis is diminished.
1
Among the most common single-gene disorders in humans, thalassemias are a cause of substantial morbidity and mortality in Asia and the Mediterranean basin.
2
Symptomatic thalassemia has historically been an uncommon illness in the United States. However, as Lal et al. report in this issue of the
Journal,
3
a moderately severe symptomatic form of α-thalassemia, hemoglobin H (HbH) disease, is being encountered with increasing frequency as Asian migration increases to the West Coast . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMe1013338</identifier><identifier>PMID: 21345108</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>alpha-Thalassemia - diagnosis ; alpha-Thalassemia - ethnology ; Asia - ethnology ; Emigration and Immigration ; Hemoglobins, Abnormal - genetics ; Humans ; Infant, Newborn ; Internationality ; Mutation ; Neonatal Screening ; United States</subject><ispartof>The New England journal of medicine, 2011-02, Vol.364 (8), p.770-771</ispartof><rights>Copyright © 2011 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-df849c8c2c031a23cee5936d5e635d75be323ff1dcc259dc0a1f7c6ac2fc2e6f3</citedby><cites>FETCH-LOGICAL-c319t-df849c8c2c031a23cee5936d5e635d75be323ff1dcc259dc0a1f7c6ac2fc2e6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMe1013338$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMe1013338$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21345108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benz, Edward J</creatorcontrib><title>Newborn Screening for α-Thalassemia — Keeping Up with Globalization</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Thalassemias are inherited disorders of hemoglobin synthesis. In α-thalassemia, the biosynthesis of the α-globin subunit of adult hemoglobin, hemoglobin A, is deficient. In β-thalassemia, β-globin synthesis is diminished.
1
Among the most common single-gene disorders in humans, thalassemias are a cause of substantial morbidity and mortality in Asia and the Mediterranean basin.
2
Symptomatic thalassemia has historically been an uncommon illness in the United States. However, as Lal et al. report in this issue of the
Journal,
3
a moderately severe symptomatic form of α-thalassemia, hemoglobin H (HbH) disease, is being encountered with increasing frequency as Asian migration increases to the West Coast . . .</description><subject>alpha-Thalassemia - diagnosis</subject><subject>alpha-Thalassemia - ethnology</subject><subject>Asia - ethnology</subject><subject>Emigration and Immigration</subject><subject>Hemoglobins, Abnormal - genetics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Internationality</subject><subject>Mutation</subject><subject>Neonatal Screening</subject><subject>United States</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkLtOwzAUhi0EoqWwMaMMSCwEbJ84lxFVbbmUMtDOkeMc01S5YaeqYOIheBFehIfgSUjVghg4yz-cT9_wEXLM6AWjwr-cDG7vkVEGAOEO6TIB4Hoe9XdJl1Ieul4QQYccWLug7TEv2icdzsATjIZdMpzgKqlM6Twqg1hm5ZOjK-N8frjTucyltVhk0vl6e3fuEOv1e1Y7q6yZO6O8SmSevcomq8pDsqdlbvFouz0yGw6m_Wt3_DC66V-NXQUsatxUh16kQsUVBSY5KEQRgZ8K9EGkgUgQOGjNUqW4iFJFJdOB8qXiWnH0NfTI2cZbm-p5ibaJi8wqzHNZYrW0cSggaoU8aMnzDalMZa1BHdcmK6R5iRmN1-Hiv-Fa_GQrXiYFpr_wT6kWON0ARWHjEhfF_55viXx1FQ</recordid><startdate>20110224</startdate><enddate>20110224</enddate><creator>Benz, Edward J</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110224</creationdate><title>Newborn Screening for α-Thalassemia — Keeping Up with Globalization</title><author>Benz, Edward J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-df849c8c2c031a23cee5936d5e635d75be323ff1dcc259dc0a1f7c6ac2fc2e6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>alpha-Thalassemia - diagnosis</topic><topic>alpha-Thalassemia - ethnology</topic><topic>Asia - ethnology</topic><topic>Emigration and Immigration</topic><topic>Hemoglobins, Abnormal - genetics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Internationality</topic><topic>Mutation</topic><topic>Neonatal Screening</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benz, Edward J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benz, Edward J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Newborn Screening for α-Thalassemia — Keeping Up with Globalization</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2011-02-24</date><risdate>2011</risdate><volume>364</volume><issue>8</issue><spage>770</spage><epage>771</epage><pages>770-771</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>Thalassemias are inherited disorders of hemoglobin synthesis. In α-thalassemia, the biosynthesis of the α-globin subunit of adult hemoglobin, hemoglobin A, is deficient. In β-thalassemia, β-globin synthesis is diminished.
1
Among the most common single-gene disorders in humans, thalassemias are a cause of substantial morbidity and mortality in Asia and the Mediterranean basin.
2
Symptomatic thalassemia has historically been an uncommon illness in the United States. However, as Lal et al. report in this issue of the
Journal,
3
a moderately severe symptomatic form of α-thalassemia, hemoglobin H (HbH) disease, is being encountered with increasing frequency as Asian migration increases to the West Coast . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>21345108</pmid><doi>10.1056/NEJMe1013338</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2011-02, Vol.364 (8), p.770-771 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_853993627 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | alpha-Thalassemia - diagnosis alpha-Thalassemia - ethnology Asia - ethnology Emigration and Immigration Hemoglobins, Abnormal - genetics Humans Infant, Newborn Internationality Mutation Neonatal Screening United States |
| title | Newborn Screening for α-Thalassemia — Keeping Up with Globalization |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T10%3A42%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Newborn%20Screening%20for%20%CE%B1-Thalassemia%20%E2%80%94%20Keeping%20Up%20with%20Globalization&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Benz,%20Edward%20J&rft.date=2011-02-24&rft.volume=364&rft.issue=8&rft.spage=770&rft.epage=771&rft.pages=770-771&rft.issn=0028-4793&rft.eissn=1533-4406&rft_id=info:doi/10.1056/NEJMe1013338&rft_dat=%3Cproquest_cross%3E853993627%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=853993627&rft_id=info:pmid/21345108&rfr_iscdi=true |