Whole-Genome Sequencing and Social-Network Analysis of a Tuberculosis Outbreak
An outbreak of tuberculosis occurred over a 3-year period in a medium-size community in British Columbia, Canada. The results of mycobacterial interspersed repetitive unit–variable-number tandem-repeat (MIRU-VNTR) genotyping suggested the outbreak was clonal. Traditional contact tracing did not id...
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| Veröffentlicht in: | The New England journal of medicine 2011-02, Vol.364 (8), p.730-739 |
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| creator | Gardy, Jennifer L Johnston, James C Sui, Shannan J. Ho Cook, Victoria J Shah, Lena Brodkin, Elizabeth Rempel, Shirley Moore, Richard Zhao, Yongjun Holt, Robert Varhol, Richard Birol, Inanc Lem, Marcus Sharma, Meenu K Elwood, Kevin Jones, Steven J.M Brinkman, Fiona S.L Brunham, Robert C Tang, Patrick |
| description | An outbreak of tuberculosis occurred over a 3-year period in a medium-size community in British Columbia, Canada. The results of mycobacterial interspersed repetitive unit–variable-number tandem-repeat (MIRU-VNTR) genotyping suggested the outbreak was clonal. Traditional contact tracing did not identify a source. We used whole-genome sequencing and social-network analysis in an effort to describe the outbreak dynamics at a higher resolution.
Mycobacterium tuberculosis
is an important infectious disease even in developed countries with extensive control programs. This is the case in British Columbia, Canada, where the 2007 incidence rate of 6.4 cases per 100,000 population exceeded the national average of 4.7 cases per 100,000 population.
1
In May 2006, a case of smear-negative pleural tuberculosis was diagnosed in an adult in a medium-size community in British Columbia. A second case, manifested as disseminated tuberculosis, was reported in an infant in July 2006. Reverse contact tracing identified nine additional cases between August and October 2006, when the British Columbia Centre for Disease Control . . . |
| doi_str_mv | 10.1056/NEJMoa1003176 |
| format | Article |
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Mycobacterium tuberculosis
is an important infectious disease even in developed countries with extensive control programs. This is the case in British Columbia, Canada, where the 2007 incidence rate of 6.4 cases per 100,000 population exceeded the national average of 4.7 cases per 100,000 population.
1
In May 2006, a case of smear-negative pleural tuberculosis was diagnosed in an adult in a medium-size community in British Columbia. A second case, manifested as disseminated tuberculosis, was reported in an infant in July 2006. Reverse contact tracing identified nine additional cases between August and October 2006, when the British Columbia Centre for Disease Control . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1003176</identifier><identifier>PMID: 21345102</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Waltham, MA: Massachusetts Medical Society</publisher><subject>Adult ; Bacterial diseases ; Biological and medical sciences ; British Columbia - epidemiology ; Cocaine-Related Disorders - complications ; Contact Tracing ; Disease Outbreaks ; Female ; General aspects ; Genome, Bacterial ; Genomes ; Genotype ; Human bacterial diseases ; Humans ; Incidence ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Mycobacterium tuberculosis - genetics ; Mycobacterium tuberculosis - isolation & purification ; Phylogeny ; Polymorphism, Single Nucleotide ; Public health ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Sequence Analysis, DNA ; Social Support ; Surveys and Questionnaires ; Tuberculosis ; Tuberculosis - epidemiology ; Tuberculosis - microbiology ; Tuberculosis - transmission ; Tuberculosis and atypical mycobacterial infections ; Young Adult</subject><ispartof>The New England journal of medicine, 2011-02, Vol.364 (8), p.730-739</ispartof><rights>Copyright © 2011 Massachusetts Medical Society. All rights reserved.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-1ca9644653caeaa489f759452a9286673814cfb55cc961396c963576a8eff85f3</citedby><cites>FETCH-LOGICAL-c528t-1ca9644653caeaa489f759452a9286673814cfb55cc961396c963576a8eff85f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1003176$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/868663073?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,2746,2747,26084,27905,27906,52363,54045,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23891263$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21345102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gardy, Jennifer L</creatorcontrib><creatorcontrib>Johnston, James C</creatorcontrib><creatorcontrib>Sui, Shannan J. Ho</creatorcontrib><creatorcontrib>Cook, Victoria J</creatorcontrib><creatorcontrib>Shah, Lena</creatorcontrib><creatorcontrib>Brodkin, Elizabeth</creatorcontrib><creatorcontrib>Rempel, Shirley</creatorcontrib><creatorcontrib>Moore, Richard</creatorcontrib><creatorcontrib>Zhao, Yongjun</creatorcontrib><creatorcontrib>Holt, Robert</creatorcontrib><creatorcontrib>Varhol, Richard</creatorcontrib><creatorcontrib>Birol, Inanc</creatorcontrib><creatorcontrib>Lem, Marcus</creatorcontrib><creatorcontrib>Sharma, Meenu K</creatorcontrib><creatorcontrib>Elwood, Kevin</creatorcontrib><creatorcontrib>Jones, Steven J.M</creatorcontrib><creatorcontrib>Brinkman, Fiona S.L</creatorcontrib><creatorcontrib>Brunham, Robert C</creatorcontrib><creatorcontrib>Tang, Patrick</creatorcontrib><title>Whole-Genome Sequencing and Social-Network Analysis of a Tuberculosis Outbreak</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>An outbreak of tuberculosis occurred over a 3-year period in a medium-size community in British Columbia, Canada. The results of mycobacterial interspersed repetitive unit–variable-number tandem-repeat (MIRU-VNTR) genotyping suggested the outbreak was clonal. Traditional contact tracing did not identify a source. We used whole-genome sequencing and social-network analysis in an effort to describe the outbreak dynamics at a higher resolution.
Mycobacterium tuberculosis
is an important infectious disease even in developed countries with extensive control programs. This is the case in British Columbia, Canada, where the 2007 incidence rate of 6.4 cases per 100,000 population exceeded the national average of 4.7 cases per 100,000 population.
1
In May 2006, a case of smear-negative pleural tuberculosis was diagnosed in an adult in a medium-size community in British Columbia. A second case, manifested as disseminated tuberculosis, was reported in an infant in July 2006. Reverse contact tracing identified nine additional cases between August and October 2006, when the British Columbia Centre for Disease Control . . .</description><subject>Adult</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>British Columbia - epidemiology</subject><subject>Cocaine-Related Disorders - complications</subject><subject>Contact Tracing</subject><subject>Disease Outbreaks</subject><subject>Female</subject><subject>General aspects</subject><subject>Genome, Bacterial</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Phylogeny</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Public health</subject><subject>Public health. Hygiene</subject><subject>Public health. 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Ho ; Cook, Victoria J ; Shah, Lena ; Brodkin, Elizabeth ; Rempel, Shirley ; Moore, Richard ; Zhao, Yongjun ; Holt, Robert ; Varhol, Richard ; Birol, Inanc ; Lem, Marcus ; Sharma, Meenu K ; Elwood, Kevin ; Jones, Steven J.M ; Brinkman, Fiona S.L ; Brunham, Robert C ; Tang, Patrick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-1ca9644653caeaa489f759452a9286673814cfb55cc961396c963576a8eff85f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>British Columbia - epidemiology</topic><topic>Cocaine-Related Disorders - complications</topic><topic>Contact Tracing</topic><topic>Disease Outbreaks</topic><topic>Female</topic><topic>General aspects</topic><topic>Genome, Bacterial</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Mycobacterium tuberculosis - isolation & purification</topic><topic>Phylogeny</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Public health</topic><topic>Public health. 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The results of mycobacterial interspersed repetitive unit–variable-number tandem-repeat (MIRU-VNTR) genotyping suggested the outbreak was clonal. Traditional contact tracing did not identify a source. We used whole-genome sequencing and social-network analysis in an effort to describe the outbreak dynamics at a higher resolution.
Mycobacterium tuberculosis
is an important infectious disease even in developed countries with extensive control programs. This is the case in British Columbia, Canada, where the 2007 incidence rate of 6.4 cases per 100,000 population exceeded the national average of 4.7 cases per 100,000 population.
1
In May 2006, a case of smear-negative pleural tuberculosis was diagnosed in an adult in a medium-size community in British Columbia. A second case, manifested as disseminated tuberculosis, was reported in an infant in July 2006. Reverse contact tracing identified nine additional cases between August and October 2006, when the British Columbia Centre for Disease Control . . .</abstract><cop>Waltham, MA</cop><pub>Massachusetts Medical Society</pub><pmid>21345102</pmid><doi>10.1056/NEJMoa1003176</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 2011-02, Vol.364 (8), p.730-739 |
| issn | 0028-4793 1533-4406 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adult Bacterial diseases Biological and medical sciences British Columbia - epidemiology Cocaine-Related Disorders - complications Contact Tracing Disease Outbreaks Female General aspects Genome, Bacterial Genomes Genotype Human bacterial diseases Humans Incidence Infectious diseases Male Medical sciences Middle Aged Miscellaneous Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Phylogeny Polymorphism, Single Nucleotide Public health Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Sequence Analysis, DNA Social Support Surveys and Questionnaires Tuberculosis Tuberculosis - epidemiology Tuberculosis - microbiology Tuberculosis - transmission Tuberculosis and atypical mycobacterial infections Young Adult |
| title | Whole-Genome Sequencing and Social-Network Analysis of a Tuberculosis Outbreak |
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