Efficacy and Safety of Derris scandens Benth Extracts in Patients with Knee Osteoarthritis
Objectives: The objectives of this study were to determine the efficacy and safety of Derris scandens Benth extracts in pain reduction and functional improvement in patients with knee osteoarthritis (OA). Design: This was a prospective, randomized, controlled trial, single-blinded (assessor). Settin...
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| Veröffentlicht in: | The journal of alternative and complementary medicine (New York, N.Y.) N.Y.), 2011-02, Vol.17 (2), p.147-153 |
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| container_title | The journal of alternative and complementary medicine (New York, N.Y.) |
| container_volume | 17 |
| creator | Kuptniratsaikul, Vilai Pinthong, Theerawut Bunjob, Malee Thanakhumtorn, Sunee Chinswangwatanakul, Pornsiri Thamlikitkul, Visanu |
| description | Objectives:
The objectives of this study were to determine the efficacy and safety of
Derris scandens
Benth extracts in pain reduction and functional improvement in patients with knee osteoarthritis (OA).
Design:
This was a prospective, randomized, controlled trial, single-blinded (assessor).
Settings:
The study was conducted at the Rehabilitation Medicine Department, Siriraj Hospital.
Subjects:
One hundred and seven (107) patients with primary OA knee who had pain score of ≥5 were recruited.
Interventions:
Patients were randomized to receive naproxen 500 mg/day or
Derris
800 mg/day for 4 weeks.
Outcome measurements:
Western Ontario McMaster Osteoarthritis Index (WOMAC) scores and 6-minute walking distance were the outcome measurements.
Results:
Fifty-five (55) and 52 patients were randomized to
Derris
and naproxen groups, respectively. The mean differences of all WOMAC scores between 2 groups at week 4 adjusted by week 0 were within ± 1 point. The mean scores of the aforementioned outcomes at weeks 0, 2, and 4 were significantly improved compared to the baseline values. There was no difference of WOMAC scores between groups. The gastrointestinal irritation and dyspepsia were observed more often in the naproxen than in the
Derris
group.
Conclusions:
Derris scandens
Benth extracts were efficacious and safe for the treatment of knee OA. |
| doi_str_mv | 10.1089/acm.2010.0213 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_853992052</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1399904703</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-eb4bd44d68313d54164560b0b9424c9c9848f254aa208f95d1e03948a679a4f93</originalsourceid><addsrcrecordid>eNqF0DtPwzAUBWALgSgURlbkDZaU69hO4pFHeQikIgELS-Q416pRmxTbFfTf46rACJPt409nOIQcMRgxqNSZNvNRDukFOeNbZI9JWWZlCdV2ukMpMym5HJD9EN4AQAiV75JBoqBKUHvkdWytM9qsqO5a-qQtxhXtLb1C712gwaQYu0AvsItTOv6MXpsYqOvoo44uhYF-uPRz3yHSSYjYax-n3kUXDsiO1bOAh9_nkLxcj58vb7OHyc3d5flDZnihYoaNaFoh2qLijLdSsELIAhpolMiFUUZVorK5FFrnUFklW4bAlah0USotrOJDcrLpXfj-fYkh1nMXDM5musN-GepKcqVykHmSp39KlqACUQJPNNtQ4_sQPNp64d1c-1XNoF4PX6fh6_Xw9Xr45I-_q5fNHNtf_bN0AnwD1rHuupnDBn38p_YL9OyOKQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1399904703</pqid></control><display><type>article</type><title>Efficacy and Safety of Derris scandens Benth Extracts in Patients with Knee Osteoarthritis</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Kuptniratsaikul, Vilai ; Pinthong, Theerawut ; Bunjob, Malee ; Thanakhumtorn, Sunee ; Chinswangwatanakul, Pornsiri ; Thamlikitkul, Visanu</creator><creatorcontrib>Kuptniratsaikul, Vilai ; Pinthong, Theerawut ; Bunjob, Malee ; Thanakhumtorn, Sunee ; Chinswangwatanakul, Pornsiri ; Thamlikitkul, Visanu</creatorcontrib><description>Objectives:
The objectives of this study were to determine the efficacy and safety of
Derris scandens
Benth extracts in pain reduction and functional improvement in patients with knee osteoarthritis (OA).
Design:
This was a prospective, randomized, controlled trial, single-blinded (assessor).
Settings:
The study was conducted at the Rehabilitation Medicine Department, Siriraj Hospital.
Subjects:
One hundred and seven (107) patients with primary OA knee who had pain score of ≥5 were recruited.
Interventions:
Patients were randomized to receive naproxen 500 mg/day or
Derris
800 mg/day for 4 weeks.
Outcome measurements:
Western Ontario McMaster Osteoarthritis Index (WOMAC) scores and 6-minute walking distance were the outcome measurements.
Results:
Fifty-five (55) and 52 patients were randomized to
Derris
and naproxen groups, respectively. The mean differences of all WOMAC scores between 2 groups at week 4 adjusted by week 0 were within ± 1 point. The mean scores of the aforementioned outcomes at weeks 0, 2, and 4 were significantly improved compared to the baseline values. There was no difference of WOMAC scores between groups. The gastrointestinal irritation and dyspepsia were observed more often in the naproxen than in the
Derris
group.
Conclusions:
Derris scandens
Benth extracts were efficacious and safe for the treatment of knee OA.</description><identifier>ISSN: 1075-5535</identifier><identifier>EISSN: 1557-7708</identifier><identifier>DOI: 10.1089/acm.2010.0213</identifier><identifier>PMID: 21309709</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Aged ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Derris ; Female ; Humans ; Knee - pathology ; Male ; Middle Aged ; Mobility Limitation ; Naproxen - adverse effects ; Naproxen - pharmacology ; Naproxen - therapeutic use ; Original Articles ; Osteoarthritis, Knee - drug therapy ; Osteoarthritis, Knee - pathology ; Pain - drug therapy ; Pain - etiology ; Phytotherapy ; Plant Components, Aerial ; Plant Extracts - adverse effects ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Prospective Studies ; Severity of Illness Index ; Single-Blind Method ; Treatment Outcome ; Walking - physiology</subject><ispartof>The journal of alternative and complementary medicine (New York, N.Y.), 2011-02, Vol.17 (2), p.147-153</ispartof><rights>2011, Mary Ann Liebert, Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-eb4bd44d68313d54164560b0b9424c9c9848f254aa208f95d1e03948a679a4f93</citedby><cites>FETCH-LOGICAL-c369t-eb4bd44d68313d54164560b0b9424c9c9848f254aa208f95d1e03948a679a4f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21309709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuptniratsaikul, Vilai</creatorcontrib><creatorcontrib>Pinthong, Theerawut</creatorcontrib><creatorcontrib>Bunjob, Malee</creatorcontrib><creatorcontrib>Thanakhumtorn, Sunee</creatorcontrib><creatorcontrib>Chinswangwatanakul, Pornsiri</creatorcontrib><creatorcontrib>Thamlikitkul, Visanu</creatorcontrib><title>Efficacy and Safety of Derris scandens Benth Extracts in Patients with Knee Osteoarthritis</title><title>The journal of alternative and complementary medicine (New York, N.Y.)</title><addtitle>J Altern Complement Med</addtitle><description>Objectives:
The objectives of this study were to determine the efficacy and safety of
Derris scandens
Benth extracts in pain reduction and functional improvement in patients with knee osteoarthritis (OA).
Design:
This was a prospective, randomized, controlled trial, single-blinded (assessor).
Settings:
The study was conducted at the Rehabilitation Medicine Department, Siriraj Hospital.
Subjects:
One hundred and seven (107) patients with primary OA knee who had pain score of ≥5 were recruited.
Interventions:
Patients were randomized to receive naproxen 500 mg/day or
Derris
800 mg/day for 4 weeks.
Outcome measurements:
Western Ontario McMaster Osteoarthritis Index (WOMAC) scores and 6-minute walking distance were the outcome measurements.
Results:
Fifty-five (55) and 52 patients were randomized to
Derris
and naproxen groups, respectively. The mean differences of all WOMAC scores between 2 groups at week 4 adjusted by week 0 were within ± 1 point. The mean scores of the aforementioned outcomes at weeks 0, 2, and 4 were significantly improved compared to the baseline values. There was no difference of WOMAC scores between groups. The gastrointestinal irritation and dyspepsia were observed more often in the naproxen than in the
Derris
group.
Conclusions:
Derris scandens
Benth extracts were efficacious and safe for the treatment of knee OA.</description><subject>Aged</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Derris</subject><subject>Female</subject><subject>Humans</subject><subject>Knee - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mobility Limitation</subject><subject>Naproxen - adverse effects</subject><subject>Naproxen - pharmacology</subject><subject>Naproxen - therapeutic use</subject><subject>Original Articles</subject><subject>Osteoarthritis, Knee - drug therapy</subject><subject>Osteoarthritis, Knee - pathology</subject><subject>Pain - drug therapy</subject><subject>Pain - etiology</subject><subject>Phytotherapy</subject><subject>Plant Components, Aerial</subject><subject>Plant Extracts - adverse effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Prospective Studies</subject><subject>Severity of Illness Index</subject><subject>Single-Blind Method</subject><subject>Treatment Outcome</subject><subject>Walking - physiology</subject><issn>1075-5535</issn><issn>1557-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0DtPwzAUBWALgSgURlbkDZaU69hO4pFHeQikIgELS-Q416pRmxTbFfTf46rACJPt409nOIQcMRgxqNSZNvNRDukFOeNbZI9JWWZlCdV2ukMpMym5HJD9EN4AQAiV75JBoqBKUHvkdWytM9qsqO5a-qQtxhXtLb1C712gwaQYu0AvsItTOv6MXpsYqOvoo44uhYF-uPRz3yHSSYjYax-n3kUXDsiO1bOAh9_nkLxcj58vb7OHyc3d5flDZnihYoaNaFoh2qLijLdSsELIAhpolMiFUUZVorK5FFrnUFklW4bAlah0USotrOJDcrLpXfj-fYkh1nMXDM5musN-GepKcqVykHmSp39KlqACUQJPNNtQ4_sQPNp64d1c-1XNoF4PX6fh6_Xw9Xr45I-_q5fNHNtf_bN0AnwD1rHuupnDBn38p_YL9OyOKQ</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Kuptniratsaikul, Vilai</creator><creator>Pinthong, Theerawut</creator><creator>Bunjob, Malee</creator><creator>Thanakhumtorn, Sunee</creator><creator>Chinswangwatanakul, Pornsiri</creator><creator>Thamlikitkul, Visanu</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20110201</creationdate><title>Efficacy and Safety of Derris scandens Benth Extracts in Patients with Knee Osteoarthritis</title><author>Kuptniratsaikul, Vilai ; Pinthong, Theerawut ; Bunjob, Malee ; Thanakhumtorn, Sunee ; Chinswangwatanakul, Pornsiri ; Thamlikitkul, Visanu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-eb4bd44d68313d54164560b0b9424c9c9848f254aa208f95d1e03948a679a4f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Derris</topic><topic>Female</topic><topic>Humans</topic><topic>Knee - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mobility Limitation</topic><topic>Naproxen - adverse effects</topic><topic>Naproxen - pharmacology</topic><topic>Naproxen - therapeutic use</topic><topic>Original Articles</topic><topic>Osteoarthritis, Knee - drug therapy</topic><topic>Osteoarthritis, Knee - pathology</topic><topic>Pain - drug therapy</topic><topic>Pain - etiology</topic><topic>Phytotherapy</topic><topic>Plant Components, Aerial</topic><topic>Plant Extracts - adverse effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Prospective Studies</topic><topic>Severity of Illness Index</topic><topic>Single-Blind Method</topic><topic>Treatment Outcome</topic><topic>Walking - physiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Kuptniratsaikul, Vilai</creatorcontrib><creatorcontrib>Pinthong, Theerawut</creatorcontrib><creatorcontrib>Bunjob, Malee</creatorcontrib><creatorcontrib>Thanakhumtorn, Sunee</creatorcontrib><creatorcontrib>Chinswangwatanakul, Pornsiri</creatorcontrib><creatorcontrib>Thamlikitkul, Visanu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of alternative and complementary medicine (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuptniratsaikul, Vilai</au><au>Pinthong, Theerawut</au><au>Bunjob, Malee</au><au>Thanakhumtorn, Sunee</au><au>Chinswangwatanakul, Pornsiri</au><au>Thamlikitkul, Visanu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and Safety of Derris scandens Benth Extracts in Patients with Knee Osteoarthritis</atitle><jtitle>The journal of alternative and complementary medicine (New York, N.Y.)</jtitle><addtitle>J Altern Complement Med</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>17</volume><issue>2</issue><spage>147</spage><epage>153</epage><pages>147-153</pages><issn>1075-5535</issn><eissn>1557-7708</eissn><abstract>Objectives:
The objectives of this study were to determine the efficacy and safety of
Derris scandens
Benth extracts in pain reduction and functional improvement in patients with knee osteoarthritis (OA).
Design:
This was a prospective, randomized, controlled trial, single-blinded (assessor).
Settings:
The study was conducted at the Rehabilitation Medicine Department, Siriraj Hospital.
Subjects:
One hundred and seven (107) patients with primary OA knee who had pain score of ≥5 were recruited.
Interventions:
Patients were randomized to receive naproxen 500 mg/day or
Derris
800 mg/day for 4 weeks.
Outcome measurements:
Western Ontario McMaster Osteoarthritis Index (WOMAC) scores and 6-minute walking distance were the outcome measurements.
Results:
Fifty-five (55) and 52 patients were randomized to
Derris
and naproxen groups, respectively. The mean differences of all WOMAC scores between 2 groups at week 4 adjusted by week 0 were within ± 1 point. The mean scores of the aforementioned outcomes at weeks 0, 2, and 4 were significantly improved compared to the baseline values. There was no difference of WOMAC scores between groups. The gastrointestinal irritation and dyspepsia were observed more often in the naproxen than in the
Derris
group.
Conclusions:
Derris scandens
Benth extracts were efficacious and safe for the treatment of knee OA.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>21309709</pmid><doi>10.1089/acm.2010.0213</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1075-5535 |
| ispartof | The journal of alternative and complementary medicine (New York, N.Y.), 2011-02, Vol.17 (2), p.147-153 |
| issn | 1075-5535 1557-7708 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_853992052 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Derris Female Humans Knee - pathology Male Middle Aged Mobility Limitation Naproxen - adverse effects Naproxen - pharmacology Naproxen - therapeutic use Original Articles Osteoarthritis, Knee - drug therapy Osteoarthritis, Knee - pathology Pain - drug therapy Pain - etiology Phytotherapy Plant Components, Aerial Plant Extracts - adverse effects Plant Extracts - pharmacology Plant Extracts - therapeutic use Prospective Studies Severity of Illness Index Single-Blind Method Treatment Outcome Walking - physiology |
| title | Efficacy and Safety of Derris scandens Benth Extracts in Patients with Knee Osteoarthritis |
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