Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo

Aim: Glucagon-like peptide-1 (GLP-1) has protective effects on pancreatic β-cells. We evaluated the effects of a novel, long-acting human GLP-1 analogue, taspoglutide, on β-cells in vitro and in vivo. Methods: Proliferation of murine pancreatic β (MIN6B1) cells and rat islets in culture was assessed...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2011-04, Vol.13 (4), p.326-336
Hauptverfasser:	Uhles, S, Wang, H, Bénardeau, A, Prummer, M, Brecheisen, M, Sewing, S, Tobalina, L, Bosco, D, Wollheim, C.B, Migliorini, C, Sebokova, E
Format:	Artikel
Sprache:	eng
Schlagworte:	animal pharmacology Animals Apoptosis Beta cells Cell culture Cell proliferation Cells, Cultured Cytokines Deoxyuridine - analogs & derivatives Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - pathology GLP-1 analogue Glucagon Glucagon-Like Peptide 1 - administration & dosage Glucagon-Like Peptide 1 - analogs & derivatives Glucagon-Like Peptide 1 - pharmacology Glucagon-Like Peptide-1 Receptor Humans Immunohistochemistry Insulin Insulin secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - pathology Insulin-Secreting Cells - physiology Insulinoma Labeling Male Palmitic acid Pancreas Peptides - administration & dosage Peptides - pharmacology Rats Rats, Zucker Receptors, Glucagon - administration & dosage Structure-function relationships Zucker diabetic fatty rat β-cells
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