Impaired Mitochondrial Function in the Preimplantation Embryo Perturbs Fetal and Placental Development in the Mouse

The preimplantation embryo is sensitive to its environment and, despite having some plasticity to adapt, environmental perturbations can impair embryo development, metabolic homeostasis, fetal and placental development, and offspring health. This study used an in vitro model of embryo culture with i...

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Veröffentlicht in:	Biology of reproduction 2011-03, Vol.84 (3), p.572-580
Hauptverfasser:	Wakefield, Sarah L, Lane, Michelle, Mitchell, Megan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminooxyacetic Acid Animals Biological and medical sciences Blastocyst - drug effects Blastocyst - pathology Blastocyst - physiology Cells, Cultured Disease Models, Animal Embryo Culture Techniques Enzyme Inhibitors Female Fetal Development - drug effects Fetal Development - physiology Fetal Growth Retardation - chemically induced Fetal Growth Retardation - etiology Fetal Growth Retardation - pathology Fetal Growth Retardation - physiopathology Fundamental and applied biological sciences. Psychology Mice Mice, Inbred C57BL Mice, Inbred CBA Mitochondria - drug effects Mitochondria - pathology Mitochondria - physiology Mitochondrial Diseases - chemically induced Mitochondrial Diseases - complications Mitochondrial Diseases - physiopathology Placenta - drug effects Placenta Diseases - etiology Placentation - drug effects Placentation - physiology Pregnancy Vertebrates: reproduction
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