Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies

Summary Background Cardiovascular risk factors are associated with dementia and cognitive decline. We investigated the effects of renin-angiotensin system blockade on cognitive function in patients aged 55 years and older with established atherosclerotic cardiovascular disease or diabetes with end-o...

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Veröffentlicht in:	Lancet neurology 2011, Vol.10 (1), p.43-53
Hauptverfasser:	Anderson, Craig, Prof, Teo, Koon, MD, Gao, Peggy, MSc, Arima, Hisatomi, MD, Dans, Antonio, MD, Unger, Thomas, MD, Commerford, Patrick, MD, Dyal, Leanne, MSc, Schumacher, Helmut, PhD, Pogue, Janice, MSc, Paolasso, Ernesto, MD, Holwerda, Nicolaas, MD, Chazova, Irina, MD, Binbrek, Azan, MD, Young, James, MD, Yusuf, Salim, DPhil
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer's disease Angiotensin Receptor Antagonists - adverse effects Angiotensin Receptor Antagonists - therapeutic use Angiotensin-Converting Enzyme Inhibitors - adverse effects Angiotensin-Converting Enzyme Inhibitors - therapeutic use Arteriosclerosis Benzimidazoles - adverse effects Benzimidazoles - therapeutic use Benzoates - adverse effects Benzoates - therapeutic use Blood pressure Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - drug therapy Clinical trials Cognition Disorders - chemically induced Cognitive ability Data processing Dementia Dementia disorders Diabetes Diabetes mellitus Disease prevention Double-Blind Method Drug development Drug dosages Drug Therapy, Combination Endocrine system Enzymes Female Follow-Up Studies Heart failure Humans Hypotheses Male Mental Status Schedule Motivation Neurology Neuropsychological Tests Odds Ratio Peptidyl-dipeptidase A Preservation Ramipril - adverse effects Ramipril - therapeutic use Renin-Angiotensin System - drug effects Renin-Angiotensin System - physiology Risk factors Stroke Treatment Outcome
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