Differential expression of toll-like receptor signaling cascades in LPS-tolerant human peripheral blood mononuclear cells

Abstract Pre-exposure to low doses of LPS induces resistance to a lethal challenge, a phenomenon known as endotoxin tolerance. In this study, tolerance was induced in human PBMC by culturing cells with 1 ng/mL LPS for 48 h. Cells were subsequently challenged with 100 ng/mL LPS for 2, 6 and 24 h, and...

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Veröffentlicht in:	Immunobiology (1979) 2011-03, Vol.216 (3), p.285-295
Hauptverfasser:	Mendes, Marialice Erdelyi, Baggio-Zappia, Giovana Lotici, Brunialti, Milena Karina Coló, Fernandes, Maria da Luz, Rapozo, Marjorie Marini, Salomao, Reinaldo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport - genetics Adult Advanced Basic Science Allergy and Immunology Cyclooxygenase 2 - genetics Endotoxins - immunology Gene expression Gene Expression Regulation Humans Immune Tolerance Innate immunity Interleukin-10 - genetics Interleukin-12 - genetics Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lipopolysaccharide Receptors - genetics Lipopolysaccharides - immunology LPS Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism NF-kappa B - genetics p38 PBMC Polymerase Chain Reaction Signal Transduction Tolerance Toll-like receptors Toll-Like Receptors - genetics Toll-Like Receptors - metabolism Tumor Necrosis Factor-alpha - genetics
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