Isorhamnetin protects rat ventricular myocytes from ischemia and reperfusion injury

Ischemia/reperfusion (I/R) has been known to cause damages to ventricular myocytes. Isorhamnetin, one member of flavonoid compounds, has cardioprotective effect, the effect that suggests a possible treatment for I/R damages. In the present investigation, we found that isorhamnetin could significantl...

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Veröffentlicht in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2011, Vol.63 (1), p.33-38
Hauptverfasser:	Zhang, Najuan, Pei, Fei, Wei, Huaying, Zhang, Tongtong, Yang, Chao, Ma, Gang, Yang, Chunlei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - biosynthesis bcl-2-Associated X Protein - genetics Biological and medical sciences Blotting, Western Cardiology. Vascular system cardioprotective effect Cell Culture Techniques Cell Survival - drug effects Cells, Cultured Flavonols - chemistry Flavonols - pharmacology Flow Cytometry Gene Expression - drug effects Heart Ventricles - drug effects Heart Ventricles - metabolism Heart Ventricles - ultrastructure Investigative techniques, diagnostic techniques (general aspects) ischemia Ischemia and reperfusion injury Isorhamnetin L-Lactate Dehydrogenase - metabolism lactate dehydrogenase Medical sciences Microscopy, Electron, Transmission Molecular Structure Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control myocytes Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - ultrastructure Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics Quercetin - analogs & derivatives Rats Transcription Factor RelA - biosynthesis Transcription Factor RelA - genetics transmission electron microscopes Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics Ventricular myocytes viability Western blotting
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