Ecotoxicity of a brominated flame retardant (tetrabromobisphenol A) and its derivatives to aquatic organisms
The large use of tetrabromobisphenol A (B 4BPA) in common products (plastics, electric and electronic equipments) has raised concern about its ecotoxicity. Physical and bio-degradations may lead to the formation of tetrabromobisphenol A derivatives like tri- (B 3BPA), di- (B 2BPA), monobromobispheno...
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| Veröffentlicht in: | Comparative biochemistry and physiology. Toxicology & pharmacology 2010-11, Vol.152 (4), p.407-412 |
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| container_title | Comparative biochemistry and physiology. Toxicology & pharmacology |
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| creator | Debenest, T. Gagné, F. Petit, A.-N. André, C. Kohli, M. Blaise, C. |
| description | The large use of tetrabromobisphenol A (B
4BPA) in common products (plastics, electric and electronic equipments) has raised concern about its ecotoxicity. Physical and bio-degradations may lead to the formation of tetrabromobisphenol A derivatives like tri- (B
3BPA), di- (B
2BPA), monobromobisphenol A (B
1BPA) and bisphenol A (BPA). However, little is known about the toxicity of these brominated derivatives. An appraisal on the ecotoxicity of B
4BPA and its derivatives was carried out with several bioassays representing organisms (bacteria, algae, micro-invertebrates and fish) of different taxonomic groups present in aquatic ecosystems. Endpoint values showed that B
4BPA was significantly less toxic than the other chemicals when tested with the Microtox and algal asssays. A similar trend was observed with other bioassays for BPA. One of the brominated derivatives was particularly toxic: B
2BPA. The LuminoTox assay and the rainbow trout hepatocytes assay reported the most significant toxicity for this derivative. Its toxicity was also significantly higher than the other compounds barring B
3BPA when tested with the micro-crustacean test. |
| doi_str_mv | 10.1016/j.cbpc.2010.06.009 |
| format | Article |
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4BPA) in common products (plastics, electric and electronic equipments) has raised concern about its ecotoxicity. Physical and bio-degradations may lead to the formation of tetrabromobisphenol A derivatives like tri- (B
3BPA), di- (B
2BPA), monobromobisphenol A (B
1BPA) and bisphenol A (BPA). However, little is known about the toxicity of these brominated derivatives. An appraisal on the ecotoxicity of B
4BPA and its derivatives was carried out with several bioassays representing organisms (bacteria, algae, micro-invertebrates and fish) of different taxonomic groups present in aquatic ecosystems. Endpoint values showed that B
4BPA was significantly less toxic than the other chemicals when tested with the Microtox and algal asssays. A similar trend was observed with other bioassays for BPA. One of the brominated derivatives was particularly toxic: B
2BPA. The LuminoTox assay and the rainbow trout hepatocytes assay reported the most significant toxicity for this derivative. Its toxicity was also significantly higher than the other compounds barring B
3BPA when tested with the micro-crustacean test.</description><identifier>ISSN: 1532-0456</identifier><identifier>EISSN: 1878-1659</identifier><identifier>DOI: 10.1016/j.cbpc.2010.06.009</identifier><identifier>PMID: 20601118</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Anostraca - drug effects ; Aquatic Organisms - drug effects ; Bacteria - drug effects ; Bioassays ; Chlorophyta - drug effects ; Cnidaria - drug effects ; Dose-Response Relationship, Drug ; Environmental toxicology ; Flame Retardants - toxicity ; Oncorhynchus mykiss ; Oncorhynchus mykiss - physiology ; Polybrominated Biphenyls - chemistry ; Polybrominated Biphenyls - toxicity ; Tetrabromobisphenol A ; Water Pollutants, Chemical - chemistry ; Water Pollutants, Chemical - toxicity</subject><ispartof>Comparative biochemistry and physiology. Toxicology & pharmacology, 2010-11, Vol.152 (4), p.407-412</ispartof><rights>2010</rights><rights>Crown © Copyright 2010. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-72ab0a981802e6da1520bf3a087db15fb5cc0af9b099550f5e4316a9c1cc3b903</citedby><cites>FETCH-LOGICAL-c453t-72ab0a981802e6da1520bf3a087db15fb5cc0af9b099550f5e4316a9c1cc3b903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cbpc.2010.06.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20601118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Debenest, T.</creatorcontrib><creatorcontrib>Gagné, F.</creatorcontrib><creatorcontrib>Petit, A.-N.</creatorcontrib><creatorcontrib>André, C.</creatorcontrib><creatorcontrib>Kohli, M.</creatorcontrib><creatorcontrib>Blaise, C.</creatorcontrib><title>Ecotoxicity of a brominated flame retardant (tetrabromobisphenol A) and its derivatives to aquatic organisms</title><title>Comparative biochemistry and physiology. Toxicology & pharmacology</title><addtitle>Comp Biochem Physiol C Toxicol Pharmacol</addtitle><description>The large use of tetrabromobisphenol A (B
4BPA) in common products (plastics, electric and electronic equipments) has raised concern about its ecotoxicity. Physical and bio-degradations may lead to the formation of tetrabromobisphenol A derivatives like tri- (B
3BPA), di- (B
2BPA), monobromobisphenol A (B
1BPA) and bisphenol A (BPA). However, little is known about the toxicity of these brominated derivatives. An appraisal on the ecotoxicity of B
4BPA and its derivatives was carried out with several bioassays representing organisms (bacteria, algae, micro-invertebrates and fish) of different taxonomic groups present in aquatic ecosystems. Endpoint values showed that B
4BPA was significantly less toxic than the other chemicals when tested with the Microtox and algal asssays. A similar trend was observed with other bioassays for BPA. One of the brominated derivatives was particularly toxic: B
2BPA. The LuminoTox assay and the rainbow trout hepatocytes assay reported the most significant toxicity for this derivative. Its toxicity was also significantly higher than the other compounds barring B
3BPA when tested with the micro-crustacean test.</description><subject>Animals</subject><subject>Anostraca - drug effects</subject><subject>Aquatic Organisms - drug effects</subject><subject>Bacteria - drug effects</subject><subject>Bioassays</subject><subject>Chlorophyta - drug effects</subject><subject>Cnidaria - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Environmental toxicology</subject><subject>Flame Retardants - toxicity</subject><subject>Oncorhynchus mykiss</subject><subject>Oncorhynchus mykiss - physiology</subject><subject>Polybrominated Biphenyls - chemistry</subject><subject>Polybrominated Biphenyls - toxicity</subject><subject>Tetrabromobisphenol A</subject><subject>Water Pollutants, Chemical - chemistry</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>1532-0456</issn><issn>1878-1659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpaJJt_0APRbcmB29GtqW1oJcQ8gULuaRnMZLGrRbb2kjapfn39bJpjznNB8-8MA9jXwUsBQh1tVk6u3XLGuYFqCWA_sDORLfqKqGk_jj3sqkraKU6Zec5bwBAtkJ9Yqc1KBBCdGdsuHWxxD_BhfLKY8-R2xTHMGEhz_sBR-KJCiaPU-EXhUrCAxBtyNvfNMWBX19ynDwPJXNPKeyxhD1lXiLHl908OB7TL5xCHvNndtLjkOnLW12wn3e3zzcP1frp_vHmel25VjalWtVoAXUnOqhJeRSyBts3CN3KWyF7K50D7LUFraWEXlLbCIXaCecaq6FZsO_H3G2KLzvKxYwhOxoGnCjusulk0660bMRM1kfSpZhzot5sUxgxvRoB5iDZbMxBsjlINqDMLHk--vYWv7Mj-f8n_6zOwI8jQPOT-0DJZBdocuRDIleMj-G9_L_uP48X</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Debenest, T.</creator><creator>Gagné, F.</creator><creator>Petit, A.-N.</creator><creator>André, C.</creator><creator>Kohli, M.</creator><creator>Blaise, C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>M7N</scope><scope>SOI</scope></search><sort><creationdate>20101101</creationdate><title>Ecotoxicity of a brominated flame retardant (tetrabromobisphenol A) and its derivatives to aquatic organisms</title><author>Debenest, T. ; Gagné, F. ; Petit, A.-N. ; André, C. ; Kohli, M. ; Blaise, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-72ab0a981802e6da1520bf3a087db15fb5cc0af9b099550f5e4316a9c1cc3b903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Anostraca - drug effects</topic><topic>Aquatic Organisms - drug effects</topic><topic>Bacteria - drug effects</topic><topic>Bioassays</topic><topic>Chlorophyta - drug effects</topic><topic>Cnidaria - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Environmental toxicology</topic><topic>Flame Retardants - toxicity</topic><topic>Oncorhynchus mykiss</topic><topic>Oncorhynchus mykiss - physiology</topic><topic>Polybrominated Biphenyls - chemistry</topic><topic>Polybrominated Biphenyls - toxicity</topic><topic>Tetrabromobisphenol A</topic><topic>Water Pollutants, Chemical - chemistry</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Debenest, T.</creatorcontrib><creatorcontrib>Gagné, F.</creatorcontrib><creatorcontrib>Petit, A.-N.</creatorcontrib><creatorcontrib>André, C.</creatorcontrib><creatorcontrib>Kohli, M.</creatorcontrib><creatorcontrib>Blaise, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Environment Abstracts</collection><jtitle>Comparative biochemistry and physiology. 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3BPA), di- (B
2BPA), monobromobisphenol A (B
1BPA) and bisphenol A (BPA). However, little is known about the toxicity of these brominated derivatives. An appraisal on the ecotoxicity of B
4BPA and its derivatives was carried out with several bioassays representing organisms (bacteria, algae, micro-invertebrates and fish) of different taxonomic groups present in aquatic ecosystems. Endpoint values showed that B
4BPA was significantly less toxic than the other chemicals when tested with the Microtox and algal asssays. A similar trend was observed with other bioassays for BPA. One of the brominated derivatives was particularly toxic: B
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| ispartof | Comparative biochemistry and physiology. Toxicology & pharmacology, 2010-11, Vol.152 (4), p.407-412 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Anostraca - drug effects Aquatic Organisms - drug effects Bacteria - drug effects Bioassays Chlorophyta - drug effects Cnidaria - drug effects Dose-Response Relationship, Drug Environmental toxicology Flame Retardants - toxicity Oncorhynchus mykiss Oncorhynchus mykiss - physiology Polybrominated Biphenyls - chemistry Polybrominated Biphenyls - toxicity Tetrabromobisphenol A Water Pollutants, Chemical - chemistry Water Pollutants, Chemical - toxicity |
| title | Ecotoxicity of a brominated flame retardant (tetrabromobisphenol A) and its derivatives to aquatic organisms |
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