Role of GacA in virulence of Vibrio vulnificus

The GacS/GacA two-component signal transduction system regulates virulence, biofilm formation and symbiosis in Vibrio species. The present study investigated this regulatory pathway in Vibrio vulnificus, a human pathogen that causes life-threatening disease associated with the consumption of raw oys...

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Veröffentlicht in:	Microbiology (Society for General Microbiology) 2010-12, Vol.156 (Pt 12), p.3722-3733
Hauptverfasser:	GAUTHIER, Julie D, JONES, Melissa K, THIAVILLE, Patrick, JOSEPH, Jennifer L, SWAIN, Rick A, KREDIET, Cory J, GULIG, Paul A, TEPLITSKI, Max, WRIGHT, Anita C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Humans Iron - metabolism Mice Mice, Inbred ICR Microbiology Miscellaneous Vibrio Vibrio Infections - microbiology Vibrio vulnificus Vibrio vulnificus - genetics Vibrio vulnificus - metabolism Vibrio vulnificus - pathogenicity Virulence
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Zusammenfassung:	The GacS/GacA two-component signal transduction system regulates virulence, biofilm formation and symbiosis in Vibrio species. The present study investigated this regulatory pathway in Vibrio vulnificus, a human pathogen that causes life-threatening disease associated with the consumption of raw oysters and wound infections. Small non-coding RNAs (csrB1, csrB2, csrB3 and csrC) commonly regulated by the GacS/GacA pathway were decreased (P
ISSN:	1350-0872 1465-2080
DOI:	10.1099/mic.0.043422-0