Synthesis of quinoline thioethers as novel small molecule enhancers of monoclonal antibody production in mammalian cell culture

A small library of novel quinoline derivatives containing different thioether substituents at position 4 have been synthesized and screened in murine hybridoma cell culture for their ability to enhance monoclonal antibody (mAb) production. From this set of compounds, four compounds have been discove...

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Veröffentlicht in:	Tetrahedron 2010-11, Vol.66 (48), p.9461-9467
Hauptverfasser:	Kazi, Shahid A., Kelso, Geoffrey F., Harris, Simon, Boysen, Reinhard I., Chowdhury, Jamil, Hearn, Milton
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotechnology Chemistry Culture Derivatives Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Hybridoma IgG Ligands Mammals Monoclonal antibodies Monoclonal antibody Organic chemistry Preparations and properties Quinoline Quinoline thioether Small molecule enhancer Synthesis (chemistry)
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