Synthesis of quinoline thioethers as novel small molecule enhancers of monoclonal antibody production in mammalian cell culture
A small library of novel quinoline derivatives containing different thioether substituents at position 4 have been synthesized and screened in murine hybridoma cell culture for their ability to enhance monoclonal antibody (mAb) production. From this set of compounds, four compounds have been discove...
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| Veröffentlicht in: | Tetrahedron 2010-11, Vol.66 (48), p.9461-9467 |
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| container_end_page | 9467 |
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| container_issue | 48 |
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| container_title | Tetrahedron |
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| creator | Kazi, Shahid A. Kelso, Geoffrey F. Harris, Simon Boysen, Reinhard I. Chowdhury, Jamil Hearn, Milton |
| description | A small library of novel quinoline derivatives containing different thioether substituents at position 4 have been synthesized and screened in murine hybridoma cell culture for their ability to enhance monoclonal antibody (mAb) production. From this set of compounds, four compounds have been discovered that enhanced immunoglobulin G (IgG) titer over negative control cultures due to an increase in specific productivity. These results demonstrate the utility of using organic synthesis and parallel ligand screening methods to discover novel cell culture additives that may be useful for increasing mAb yield in industrial biomanufacturing processes.
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| doi_str_mv | 10.1016/j.tet.2010.09.020 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Tetrahedron, 2010-11, Vol.66 (48), p.9461-9467 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Biotechnology Chemistry Culture Derivatives Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Hybridoma IgG Ligands Mammals Monoclonal antibodies Monoclonal antibody Organic chemistry Preparations and properties Quinoline Quinoline thioether Small molecule enhancer Synthesis (chemistry) |
| title | Synthesis of quinoline thioethers as novel small molecule enhancers of monoclonal antibody production in mammalian cell culture |
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