Regulation of osteoclast differentiation and function by the CaMK-CREB pathway

Calcium (Ca 2+ ) signaling is essential for a variety of cellular responses and higher biological functions. Ca 2+ /calmodulin-dependent kinases (CaMKs) and the phosphatase calcineurin activate distinct downstream pathways that are mediated by the transcription factors cAMP response element (CRE)-bi...

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Veröffentlicht in:	Nature medicine 2006-12, Vol.12 (12), p.1410-1416
Hauptverfasser:	Sato, Kojiro, Suematsu, Ayako, Nakashima, Tomoki, Takemoto-Kimura, Sayaka, Aoki, Kazuhiro, Morishita, Yasuyuki, Asahara, Hiroshi, Ohya, Keiichi, Yamaguchi, Akira, Takai, Toshiyuki, Kodama, Tatsuhiko, Chatila, Talal A, Bito, Haruhiko, Takayanagi, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Bone Resorption - genetics Bones Calcium Calcium-Calmodulin-Dependent Protein Kinase Type 4 Calcium-Calmodulin-Dependent Protein Kinases - genetics Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cancer Research Cell Differentiation Cells, Cultured Cyclic AMP Response Element-Binding Protein - metabolism Gene expression Infectious Diseases letter Metabolic Diseases Metabolism Mice Mice, Inbred C57BL Mice, Knockout Models, Biological Molecular Medicine Molecular Sequence Data Neurosciences NFATC Transcription Factors - metabolism Osteoclasts - physiology Phosphorylation Proteins Proto-Oncogene Proteins c-fos - metabolism RANK Ligand - pharmacology Signal Transduction
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