Genetic mapping of a mouse ocular malformation locus, Tcm, to chromosome 4

The Tcm mutation in the mouse is an autosomal dominant ocular malformation manifesting as microphthalmia, iris dysplasia, cataract, and coloboma. As a first step to cloning the Tcm gene, we report the localization of the Tcm mutation with respect to known microsatellite markers. Backcross progeny ca...

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Veröffentlicht in:	Mammalian genome 1997-03, Vol.8 (3), p.178-181
Hauptverfasser:	Zhou, E, Grimes, P, Favor, J, Koeberlein, B, Pretsch, W, Neuhauser-Klaus, A, Sidjanin, D, Stambolian, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Multiple - genetics Animals Chromosome 4 Chromosome Mapping Cloning Dysplasia Eye Abnormalities - genetics Eye Abnormalities - pathology Female Gene mapping Genetic markers Genetics Localization Male Mice Mice, Inbred C3H Mice, Inbred C57BL Microphthalmia Microsatellites Mutation Phenotypes Polymorphism, Genetic Tcm gene
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