Delta-9-tetrahydrocannabinol protects cardiac cells from hypoxia via CB2 receptor activation and nitric oxide production

Delta-9-tetrahydrocannabinol (THC), the major active component of marijuana, has a beneficial effect on the cardiovascular system during stress conditions, but the defence mechanism is still unclear. The present study was designed to investigate the central (CB1) and the peripheral (CB2) cannabinoid...

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Veröffentlicht in:	Molecular and cellular biochemistry 2006-02, Vol.283 (1-2), p.75-83
Hauptverfasser:	Shmist, Yelena A, Goncharov, Igor, Eichler, Maor, Shneyvays, Vladimir, Isaac, Ahuva, Vogel, Zvi, Shainberg, Asher
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Analgesics, Non-Narcotic - therapeutic use Animals Animals, Newborn Cardiomyocytes Cardiovascular system Dronabinol - therapeutic use Glioma - drug therapy Glioma - metabolism Hypoxia Hypoxia - drug therapy L-Lactate Dehydrogenase - metabolism Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Rats Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB2 - metabolism Signal Transduction - drug effects Tumor Cells, Cultured
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